Search Results - "Richardson, Andrea"

Paracrine and Autocrine Signals Induce and Maintain Mesenchymal and Stem Cell States in the Breast by Scheel, Christina, Eaton, Elinor Ng, Li, Sophia Hsin-Jung, Chaffer, Christine L., Reinhardt, Ferenc, Kah, Kong-Jie, Bell, George, Guo, Wenjun, Rubin, Jeffrey, Richardson, Andrea L., Weinberg, Robert A.

“…The epithelial-mesenchymal transition (EMT) has been associated with the acquisition of motility, invasiveness, and self-renewal traits. During both normal…”
Get full text

Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine by Briggs, Kimberly J., Koivunen, Peppi, Cao, Shugeng, Backus, Keriann M., Olenchock, Benjamin A., Patel, Hetalben, Zhang, Qing, Signoretti, Sabina, Gerfen, Gary J., Richardson, Andrea L., Witkiewicz, Agnieszka K., Cravatt, Benjamin F., Clardy, Jon, Kaelin, William G.

“…The HIF transcription factor promotes adaptation to hypoxia and stimulates the growth of certain cancers, including triple-negative breast cancer (TNBC). The…”
Get full text

MicroRNA-Antagonism Regulates Breast Cancer Stemness and Metastasis via TET-Family-Dependent Chromatin Remodeling by Song, Su Jung, Poliseno, Laura, Song, Min Sup, Ala, Ugo, Webster, Kaitlyn, Ng, Christopher, Beringer, Gary, Brikbak, Nicolai J., Yuan, Xin, Cantley, Lewis C., Richardson, Andrea L., Pandolfi, Pier Paolo

“…Tumor cells metastasize to distant organs through genetic and epigenetic alterations, including changes in microRNA (miR) expression. Here we find miR-22…”
Get full text

Genomic Evolution of Breast Cancer Metastasis and Relapse by Yates, Lucy R., Knappskog, Stian, Wedge, David, Farmery, James H.R., Gonzalez, Santiago, Martincorena, Inigo, Alexandrov, Ludmil B., Van Loo, Peter, Haugland, Hans Kristian, Lilleng, Peer Kaare, Gundem, Gunes, Gerstung, Moritz, Pappaemmanuil, Elli, Gazinska, Patrycja, Bhosle, Shriram G., Jones, David, Raine, Keiran, Mudie, Laura, Latimer, Calli, Sawyer, Elinor, Desmedt, Christine, Sotiriou, Christos, Stratton, Michael R., Sieuwerts, Anieta M., Lynch, Andy G., Martens, John W., Richardson, Andrea L., Tutt, Andrew, Lønning, Per Eystein, Campbell, Peter J.

“…Patterns of genomic evolution between primary and metastatic breast cancer have not been studied in large numbers, despite patients with metastatic breast…”
Get full text

Homologous Recombination Deficiency (HRD) Score Predicts Response to Platinum-Containing Neoadjuvant Chemotherapy in Patients with Triple-Negative Breast Cancer by Telli, Melinda L, Timms, Kirsten M, Reid, Julia, Hennessy, Bryan, Mills, Gordon B, Jensen, Kristin C, Szallasi, Zoltan, Barry, William T, Winer, Eric P, Tung, Nadine M, Isakoff, Steven J, Ryan, Paula D, Greene-Colozzi, April, Gutin, Alexander, Sangale, Zaina, Iliev, Diana, Neff, Chris, Abkevich, Victor, Jones, Joshua T, Lanchbury, Jerry S, Hartman, Anne-Renee, Garber, Judy E, Ford, James M, Silver, Daniel P, Richardson, Andrea L

“…BRCA1/2-mutated and some sporadic triple-negative breast cancers (TNBC) have DNA repair defects and are sensitive to DNA-damaging therapeutics. Recently, three…”
Get full text

Spatial genomics maps the structure, nature and evolution of cancer clones by Lomakin, Artem, Svedlund, Jessica, Strell, Carina, Gataric, Milana, Shmatko, Artem, Rukhovich, Gleb, Park, Jun Sung, Ju, Young Seok, Dentro, Stefan, Kleshchevnikov, Vitalii, Vaskivskyi, Vasyl, Li, Tong, Bayraktar, Omer Ali, Pinder, Sarah, Richardson, Andrea L., Santagata, Sandro, Campbell, Peter J., Russnes, Hege, Gerstung, Moritz, Nilsson, Mats, Yates, Lucy R.

“…Genome sequencing of cancers often reveals mosaics of different subclones present in the same tumour 1 – 3 . Although these are believed to arise according to…”
Get full text

Breast cancer prognostic classification in the molecular era: the role of histological grade by Rakha, Emad A, Reis-Filho, Jorge S, Baehner, Frederick, Dabbs, David J, Decker, Thomas, Eusebi, Vincenzo, Fox, Stephen B, Ichihara, Shu, Jacquemier, Jocelyne, Lakhani, Sunil R, Palacios, José, Richardson, Andrea L, Schnitt, Stuart J, Schmitt, Fernando C, Tan, Puay-Hoon, Tse, Gary M, Badve, Sunil, Ellis, Ian O

“…Breast cancer is a heterogeneous disease with varied morphological appearances, molecular features, behavior, and response to therapy. Current routine clinical…”
Get full text

Autocrine TGF-β and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts by Kojima, Yasushi, Acar, Ahmet, Eaton, Elinor Ng, Mellody, Kieran T, Scheel, Christina, Ben-Porath, Ittai, Onder, Tamer T, Wang, Zhigang C, Richardson, Andrea L, Weinberg, Robert A, Orimo, Akira

“…Much interest is currently focused on the emerging role of tumor-stroma interactions essential for supporting tumor progression. Carcinoma-associated…”
Get full text

Correlation of homologous recombination deficiency induced mutational signatures with sensitivity to PARP inhibitors and cytotoxic agents by Póti, Ádám, Gyergyák, Hella, Németh, Eszter, Rusz, Orsolya, Tóth, Szilárd, Kovácsházi, Csenger, Chen, Dan, Szikriszt, Bernadett, Spisák, Sándor, Takeda, Shunichi, Szakács, Gergely, Szallasi, Zoltan, Richardson, Andrea L, Szüts, Dávid

“…Homologous recombination (HR) repair deficiency arising from defects in BRCA1 or BRCA2 is associated with characteristic patterns of somatic mutations. In this…”
Get full text

Two for the GOES: Exploring Gambling Outcome Expectancies Scores Across Mixed and Offline-Only Gamblers in Relation to Problem Gambling Risk Status by Richardson, Andrea C., Flack, Mal, Caudwell, Kim M.

“…As online gambling becomes more prevalent, understanding the motives of online gamblers has become a key focus for research and practice. The aim of this study…”
Get full text

Tumor mutation burden forecasts outcome in ovarian cancer with BRCA1 or BRCA2 mutations by Birkbak, Nicolai Juul, Kochupurakkal, Bose, Izarzugaza, Jose M G, Eklund, Aron C, Li, Yang, Liu, Joyce, Szallasi, Zoltan, Matulonis, Ursula A, Richardson, Andrea L, Iglehart, J Dirk, Wang, Zhigang C

“…Increased number of single nucleotide substitutions is seen in breast and ovarian cancer genomes carrying disease-associated mutations in BRCA1 or BRCA2. The…”
Get full text

Homologous recombination deficiency (HRD) score in germline BRCA2- versus ATM-altered prostate cancer by Lotan, Tamara L., Kaur, Harsimar B., Salles, Daniela C., Murali, Sanjana, Schaeffer, Edward M., Lanchbury, Jerry S., Isaacs, William B., Brown, Robert, Richardson, Andrea L., Cussenot, Olivier, Cancel-Tassin, Geraldine, Timms, Kirsten M., Antonarakis, Emmanuel S.

“…The homologous recombination deficiency (HRD) score integrates three DNA-based measures of genomic instability, and has been understudied in prostate cancer…”
Get full text

Subtle variations in Pten dose determine cancer susceptibility by Alimonti, Andrea, Carracedo, Arkaitz, Nardella, Caterina, Sampieri, Katia, Richardson, Andrea L, Brogi, Edi, Pandolfi, Pier Paolo, Haveman, William J, Egia, Ainara, Zhang, Jiangwen, Trotman, Lloyd C, Salmena, Leonardo, Clohessy, John G

“…Cancer susceptibility has been attributed to at least one heterozygous genetic alteration in a tumor suppressor gene (TSG). It has been hypothesized that…”
Get full text

Application of desorption electrospray ionization mass spectrometry imaging in breast cancer margin analysis by Calligaris, David, Caragacianu, Diana, Liu, Xiaohui, Norton, Isaiah, Thompson, Christopher J., Richardson, Andrea L., Golshan, Mehra, Easterling, Michael L., Santagata, Sandro, Dillon, Deborah A., Jolesz, Ferenc A., Agar, Nathalie Y. R.

“…Significance This study is the first demonstration, to our knowledge, of the application of desorption electrospray ionization mass spectrometry imaging…”
Get full text

HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures by Davies, Helen, Glodzik, Dominik, Morganella, Sandro, Yates, Lucy R, Staaf, Johan, Zou, Xueqing, Ramakrishna, Manasa, Martin, Sancha, Boyault, Sandrine, Sieuwerts, Anieta M, Simpson, Peter T, King, Tari A, Raine, Keiran, Eyfjord, Jorunn E, Kong, Gu, Borg, Åke, Birney, Ewan, Stunnenberg, Hendrik G, van de Vijver, Marc J, Børresen-Dale, Anne-Lise, Martens, John W M, Span, Paul N, Lakhani, Sunil R, Vincent-Salomon, Anne, Sotiriou, Christos, Tutt, Andrew, Thompson, Alastair M, Van Laere, Steven, Richardson, Andrea L, Viari, Alain, Campbell, Peter J, Stratton, Michael R, Nik-Zainal, Serena

“…HRDetect represents a model integrating whole-genome sequencing mutation signatures associated with BRCA1 and BRCA2 deficiency. The implementation of this…”
Get full text

CDK12 Inhibition Reverses De Novo and Acquired PARP Inhibitor Resistance in BRCA Wild-Type and Mutated Models of Triple-Negative Breast Cancer by Johnson, Shawn F., Cruz, Cristina, Greifenberg, Ann Katrin, Dust, Sofia, Stover, Daniel G., Chi, David, Primack, Benjamin, Cao, Shiliang, Bernhardy, Andrea J., Coulson, Rhiannon, Lazaro, Jean-Bernard, Kochupurakkal, Bose, Sun, Heather, Unitt, Christine, Moreau, Lisa A., Sarosiek, Kristopher A., Scaltriti, Maurizio, Juric, Dejan, Baselga, José, Richardson, Andrea L., Rodig, Scott J., D’Andrea, Alan D., Balmaña, Judith, Johnson, Neil, Geyer, Matthias, Serra, Violeta, Lim, Elgene, Shapiro, Geoffrey I.

“…Although poly(ADP-ribose) polymerase (PARP) inhibitors are active in homologous recombination (HR)-deficient cancers, their utility is limited by acquired…”
Get full text

Timing and Duration of Obesity in Relation to Diabetes: Findings from an ethnically diverse, nationally representative sample by THE, Natalie S, RICHARDSON, Andrea S, GORDON-LARSEN, Penny

“…The influence on diabetes of the timing and duration of obesity across the high-risk period of adolescence to young adulthood has not been investigated in a…”
Get full text

Proof of concept, randomized, placebo-controlled study of the effect of simvastatin on the course of age-related macular degeneration by Guymer, Robyn H, Baird, Paul N, Varsamidis, Mary, Busija, Lucy, Dimitrov, Peter N, Aung, Khin Zaw, Makeyeva, Galina A, Richardson, Andrea J, Lim, Lyndell, Robman, Liubov D

“…HMG Co-A reductase inhibitors are ubiquitous in our community yet their potential role in age-related macular degeneration (AMD) remains to be determined. To…”
Get full text

Organoid cultures from normal and cancer-prone human breast tissues preserve complex epithelial lineages by Rosenbluth, Jennifer M., Schackmann, Ron C. J., Gray, G. Kenneth, Selfors, Laura M., Li, Carman Man-Chung, Boedicker, Mackenzie, Kuiken, Hendrik J., Richardson, Andrea, Brock, Jane, Garber, Judy, Dillon, Deborah, Sachs, Norman, Clevers, Hans, Brugge, Joan S.

“…Recently, organoid technology has been used to generate a large repository of breast cancer organoids. Here we present an extensive evaluation of the ability…”
Get full text

Food Insecurity in a Low-Income, Predominantly African American Cohort Following the COVID-19 Pandemic by Dubowitz, Tamara, Dastidar, Madhumita Ghosh, Troxel, Wendy M, Beckman, Robin, Nugroho, Alvin, Siddiqi, Sameer, Cantor, Jonathan, Baird, Matthew, Richardson, Andrea S, Hunter, Gerald P, Mendoza-Graf, Alexandra, Collins, Rebecca L

“…To examine the impact of COVID-19 shutdowns on food insecurity among a predominantly African American cohort residing in low-income racially isolated…”
Get full text