Search Results - "Richards, David F."

Enhanced production of IL-17A in patients with severe asthma is inhibited by 1α,25-dihydroxyvitamin D3 in a glucocorticoid-independent fashion by Nanzer, Alexandra M., MRCP, Chambers, Emma S., MSc, Ryanna, Kimuli, MRCP, Richards, David F., MSc, Black, Cheryl, PhD, Timms, Peter M., FRCPath, Martineau, Adrian R., PhD, Griffiths, Christopher J., FRCGP, Corrigan, Christopher J., PhD, Hawrylowicz, Catherine M., PhD

“…Background TH 17 cells are proposed to play a role in the pathology of asthma, including steroid-resistant (SR) disease. We previously identified a…”
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A Satellite-Based Approach for Quantifying Terrestrial Water Cycle Intensity by Zowam, Fabian J., Milewski, Adam M., Richards IV, David F.

“…The terrestrial water cycle intensity (WCI) is a widely used tool to quantify the impact of climate change on the distribution of global water resources. In…”
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Evaluation and Analysis of Remote Sensing-Based Approach for Salt Marsh Monitoring by Richards, David F., Milewski, Adam M., Becker, Steffan, Donaldson, Yonesha, Davidson, Lea J., Zowam, Fabian J., Mrazek, Jay, Durham, Michael

“…In the United States (US), salt marshes are especially vulnerable to the effects of projected sea level rise, increased storm frequency, and climatic changes…”
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The effects of calcitriol treatment in glucocorticoid-resistant asthma by Nanzer, Alexandra M., MRCP, Chambers, Emma S., PhD, Ryanna, Kimuli, MRCP, Freeman, Anna T., MRCP, Colligan, Grainne, BSc, Richards, David F., MSc, Timms, Peter M., FRCPath, Martineau, Adrian R., PhD, Griffiths, Christopher J., FRCGP, Corrigan, Christopher J., PhD, Hawrylowicz, Catherine M., PhD

“…A number of mechanisms have been proposed to contribute to glucocorticoid-resistant asthma, including increased expression of nuclear factor kappa B and…”
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Serum 25-dihydroxyvitamin D levels correlate with CD4+ Foxp3+ T-cell numbers in moderate/severe asthma by Chambers, Emma S., MSc, Nanzer, Alexandra M., MRCP, Richards, David F., MSc, Ryanna, Kimuli, MRCP, Freeman, Anna T., MRCP, Timms, Peter M., FRCPath, Martineau, Adrian R., PhD, Griffiths, Christopher J., FRCGP, Corrigan, Christopher J., PhD, Hawrylowicz, Catherine M., PhD

“…Corticosteroids enhance the production of the antiinflammatory cytokine IL-10 by T cells in vitro, but notably this response is impaired in cultures from SR…”
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Vitamin D binding protein and asthma severity in children by Gupta, Atul, MRCPCH, Dimeloe, Sarah, MPharm, PhD, Richards, David F., MSc, Bush, Andrew, MD, FCRP, FRCPCH, Saglani, Sejal, MD, MRCP, MRCPCH, Hawrylowicz, Catherine M., PhD

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Distinct endotypes of steroid-resistant asthma characterized by IL-17Ahigh and IFN-γhigh immunophenotypes: Potential benefits of calcitriol by Chambers, Emma S., PhD, Nanzer, Alexandra M., MRCP, Pfeffer, Paul E., MRCP, Richards, David F., MSc, Timms, Peter M., FRCPath, Martineau, Adrian R., PhD, Griffiths, Christopher J., FRCGP, Corrigan, Christopher J., PhD, Hawrylowicz, Catherine M., PhD

“…Background A small population of patients with severe asthma does not respond to glucocorticoids (steroid resistant [SR]). They have high morbidity,…”
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Distinct endotypes of steroid-resistant asthma characterized by IL-17A(high) and IFN-γ(high) immunophenotypes: Potential benefits of calcitriol by Chambers, Emma S, Nanzer, Alexandra M, Pfeffer, Paul E, Richards, David F, Timms, Peter M, Martineau, Adrian R, Griffiths, Christopher J, Corrigan, Christopher J, Hawrylowicz, Catherine M

“…A small population of patients with severe asthma does not respond to glucocorticoids (steroid resistant [SR]). They have high morbidity, highlighting an…”
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Molecular dynamics simulations of classical stopping power by Grabowski, Paul E, Surh, Michael P, Richards, David F, Graziani, Frank R, Murillo, Michael S

“…Molecular dynamics can provide very accurate tests of classical kinetic theory; for example, unambiguous comparisons can be made for classical particles…”
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Defective IL-10 expression and in vitro steroid-induced IL-17A in paediatric severe therapy-resistant asthma by Gupta, Atul, Dimeloe, Sarah, Richards, David F, Chambers, Emma S, Black, Cheryl, Urry, Zoe, Ryanna, Kimuli, Xystrakis, Emmanuel, Bush, Andrew, Saglani, Sejal, Hawrylowicz, Catherine M

“…Understanding of immune mechanisms underpinning asthma has emerged from studies in adults. It is increasingly recognised, both immunologically and in the…”
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Ligation of TLR9 induced on human IL-10–secreting Tregs by 1α,25-dihydroxyvitamin D3 abrogates regulatory function by Urry, Zoe, Xystrakis, Emmanuel, Richards, David F, McDonald, Joanne, Sattar, Zahid, Cousins, David J, Corrigan, Christopher J, Hickman, Emma, Brown, Zarin, Hawrylowicz, Catherine M

“…Signaling through the TLR family of molecular pattern recognition receptors has been implicated in the induction of innate and adaptive immune responses. A…”
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Vitamin D (1,25(OH) 2 D3) induces α-1-antitrypsin synthesis by CD4 + T cells, which is required for 1,25(OH) 2 D3-driven IL-10 by Dimeloe, Sarah, Rice, Louise V, Chen, Hebe, Cheadle, Charlotte, Raynes, John, Pfeffer, Paul, Lavender, Paul, Richards, David F, Nyon, Mun Peak, McDonnell, James M, Kemper, Claudia, Gooptu, Bibek, Hawrylowicz, Catherine M

“…Studies to identify novel immune-regulatory functions of active vitamin D (1,25(OH) D3) in human CD4 T cells revealed that 1,25(OH) D3 potently induced…”
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1α,25‐dihydroxyvitamin D3 in combination with transforming growth factor‐β increases the frequency of Foxp3+ regulatory T cells through preferential expansion and usage of interleukin‐2 by Chambers, Emma S., Suwannasaen, Duangchan, Mann, Elizabeth H., Urry, Zoe, Richards, David F., Lertmemongkolchai, Ganjana, Hawrylowicz, Catherine M.

“…Summary A high prevalence of vitamin D insufficiency and deficiency exists worldwide, which is associated with an increased incidence and severity of a range…”
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1 α ,25‐dihydroxyvitamin D3 in combination with transforming growth factor‐ β increases the frequency of Foxp3 + regulatory T cells through preferential expansion and usage of interleukin‐2 by Chambers, Emma S., Suwannasaen, Duangchan, Mann, Elizabeth H., Urry, Zoe, Richards, David F., Lertmemongkolchai, Ganjana, Hawrylowicz, Catherine M.

“…Summary A high prevalence of vitamin D insufficiency and deficiency exists worldwide, which is associated with an increased incidence and severity of a range…”
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Vitamin D (1,25(OH)2D3) induces α-1-antitrypsin synthesis by CD4+ T cells, which is required for 1,25(OH)2D3-driven IL-10 by Dimeloe, Sarah, Rice, Louise V., Chen, Hebe, Cheadle, Charlotte, Raynes, John, Pfeffer, Paul, Lavender, Paul, Richards, David F., Nyon, Mun Peak, McDonnell, James M., Kemper, Claudia, Gooptu, Bibek, Hawrylowicz, Catherine M.

“…•Human CD4+ T cells exposed to 1,25(OH)2D3 secrete α-1-antitrypsin – representing a novel cellular source of this protein.•α-1-Antitrypsin promotes IL-10…”
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Regulation of GM-CSF expression by the transcription factor c-Maf by Gilmour, Jane, PhD, Cousins, David J., PhD, Richards, David F., MSc, Sattar, Zahid, PhD, Lee, Tak H., MD, DSc, Lavender, Paul, PhD

“…Background Inflammation is a key feature of asthma and allergic disease. The proinflammatory cytokines IL-4 , IL-5 , and IL-13 are clustered on chromosome 5q…”
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Reversing the defective induction of IL-10-secreting regulatory T cells in glucocorticoid-resistant asthma patients by Xystrakis, Emmanuel, Kusumakar, Siddharth, Boswell, Sandra, Peek, Emma, Urry, Zoë, Richards, David F, Adikibi, Tonye, Pridgeon, Carol, Dallman, Margaret, Loke, Tuck-Kay, Robinson, Douglas S, Barrat, Franck J, O'Garra, Anne, Lavender, Paul, Lee, Tak H, Corrigan, Christopher, Hawrylowicz, Catherine M

“…We previously reported that human CD4+ Tregs secrete high levels of IL-10 when stimulated in the presence of dexamethasone and calcitriol (vitamin D3). We now…”
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A high-resolution computational model of the deforming human heart by Gurev, Viatcheslav, Pathmanathan, Pras, Fattebert, Jean-Luc, Wen, Hui-Fang, Magerlein, John, Gray, Richard A., Richards, David F., Rice, J. Jeremy

“…Modeling of the heart ventricles is one of the most challenging tasks in soft tissue mechanics because cardiac tissue is a strongly anisotropic incompressible…”
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Evaluating and extending user-level fault tolerance in MPI applications by Laguna, Ignacio, Richards, David F, Gamblin, Todd, Schulz, Martin, de Supinski, Bronis R, Mohror, Kathryn, Pritchard, Howard

“…The user-level failure mitigation (ULFM) interface has been proposed to provide fault-tolerant semantics in the Message Passing Interface (MPI). Previous work…”
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In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines by Barrat, Franck J, Cua, Daniel J, Boonstra, André, Richards, David F, Crain, Chad, Savelkoul, Huub F, de Waal-Malefyt, René, Coffman, Robert L, Hawrylowicz, Catherine M, O'Garra, Anne

“…We show that a combination of the immunosuppressive drugs, vitamin D3 and Dexamethasone, induced human and mouse naive CD4(+) T cells to differentiate in vitro…”
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