Search Results - "Richard Bates, C"

Antibody-Drug Conjugate-Based Therapeutics: State of the Science by Birrer, Michael J, Moore, Kathleen N, Betella, Ilaria, Bates, Richard C

“…Abstract Antibody-drug conjugates (ADCs) are complex engineered therapeutics consisting of monoclonal antibodies, directed toward tumor-associated antigens, to…”
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Targeted inhibition of the molecular chaperone Hsp90 overcomes ALK inhibitor resistance in non-small cell lung cancer by Sang, Jim, Acquaviva, Jaime, Friedland, Julie C, Smith, Donald L, Sequeira, Manuel, Zhang, Chaohua, Jiang, Qin, Xue, Liquan, Lovly, Christine M, Jimenez, John-Paul, Shaw, Alice T, Doebele, Robert C, He, Suqin, Bates, Richard C, Camidge, D Ross, Morris, Stephan W, El-Hariry, Iman, Proia, David A

“…EML4-ALK gene rearrangements define a unique subset of patients with non-small cell lung carcinoma (NSCLC), and the clinical success of the anaplastic lymphoma…”
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The HSP90 inhibitor ganetespib has chemosensitizer and radiosensitizer activity in colorectal cancer by He, Suqin, Smith, Donald L., Sequeira, Manuel, Sang, Jim, Bates, Richard C., Proia, David A.

“…Summary The integration of targeted agents to standard cytotoxic regimens has improved outcomes for patients with colorectal cancer (CRC) over recent years;…”
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FGFR3 translocations in bladder cancer: differential sensitivity to HSP90 inhibition based on drug metabolism by Acquaviva, Jaime, He, Suqin, Zhang, Chaohua, Jimenez, John-Paul, Nagai, Masazumi, Sang, Jim, Sequeira, Manuel, Smith, Donald L, Ogawa, Luisa Shin, Inoue, Takayo, Tatsuta, Noriaki, Knowles, Margaret A, Bates, Richard C, Proia, David A

“…Activating mutations and/or overexpression of FGFR3 are common in bladder cancer, making FGFR3 an attractive therapeutic target in this disease. In addition,…”
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mTOR inhibition potentiates HSP90 inhibitor activity via cessation of HSP synthesis by Acquaviva, Jaime, He, Suqin, Sang, Jim, Smith, Donald L, Sequeira, Manuel, Zhang, Chaohua, Bates, Richard C, Proia, David A

“…Because of their pleiotropic effects on critical oncoproteins, inhibitors of HSP90 represent a promising new class of therapeutic agents for the treatment of…”
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Characterisation of subglacial water using a constrained transdimensional Bayesian transient electromagnetic inversion by Killingbeck, Siobhan F, Booth, Adam D, Livermore, Philip W, Bates, C. Richard, West, Landis J

“…Subglacial water modulates glacier-bed friction and therefore is of fundamental importance when characterising the dynamics of ice masses. The state of…”
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Multifaceted intervention by the Hsp90 inhibitor ganetespib (STA-9090) in cancer cells with activated JAK/STAT signaling by Proia, David A, Foley, Kevin P, Korbut, Tim, Sang, Jim, Smith, Don, Bates, Richard C, Liu, Yuan, Rosenberg, Alex F, Zhou, Dan, Koya, Keizo, Barsoum, James, Blackman, Ronald K

“…There is accumulating evidence that dysregulated JAK signaling occurs in a wide variety of cancer types. In particular, mutations in JAK2 can result in the…”
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Altered localization of p120 catenin during epithelial to mesenchymal transition of colon carcinoma is prognostic for aggressive disease by BELLOVIN, David I, BATES, Richard C, MUZIKANSKY, Alona, RIMM, David L, MERCURIO, Arthur M

“…We examined the expression and localization of p120 catenin (p120ctn) as a consequence of the epithelial to mesenchymal transition (EMT) of highly…”
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The HSP90 Inhibitor Ganetespib Alleviates Disease Progression and Augments Intermittent Cyclophosphamide Therapy in the MRL/lpr Mouse Model of Systemic Lupus Erythematosus by Liu, Yuan, Ye, Josephine, Shin Ogawa, Luisa, Inoue, Takayo, Huang, Qin, Chu, John, Bates, Richard C, Ying, Weiwen, Sonderfan, Andrew J, Rao, Patricia E, Zhou, Dan

“…Systemic lupus erythematosus (SLE) is a complex, systemic autoimmune disease with a diverse range of immunological and clinical manifestations. The…”
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The epithelial–mesenchymal transition of colon carcinoma involves expression of IL-8 and CXCR-1-mediated chemotaxis by Bates, Richard C., DeLeo, Michael J., Mercurio, Arthur M.

“…The epithelial–mesenchymal transition (EMT) is an essential component of embryonic development, tissue remodeling, and wound repair. In addition, many…”
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Ganetespib and HSP90: Translating Preclinical Hypotheses into Clinical Promise by PROIA, David A, BATES, Richard C

“…As with many physiologic processes that become subverted during tumorigenesis, the chaperoning activity of heat shock protein 90 (HSP90) is often exploited by…”
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150,000-year palaeoclimate record from northern Ethiopia supports early, multiple dispersals of modern humans from Africa by Lamb, Henry F., Bates, C. Richard, Bryant, Charlotte L., Davies, Sarah J., Huws, Dei G., Marshall, Michael H., Roberts, Helen M., Toland, Harry

“…Climatic change is widely acknowledged to have played a role in the dispersal of modern humans out of Africa, but the timing is contentious. Genetic evidence…”
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Overcoming acquired BRAF inhibitor resistance in melanoma via targeted inhibition of Hsp90 with ganetespib by Acquaviva, Jaime, Smith, Donald L, Jimenez, John-Paul, Zhang, Chaohua, Sequeira, Manuel, He, Suqin, Sang, Jim, Bates, Richard C, Proia, David A

“…Activating BRAF kinase mutations serve as oncogenic drivers in over half of all melanomas, a feature that has been exploited in the development of new…”
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Mapping serpulid worm reefs (Polychaeta: Serpulidae) for conservation management by Moore, Colin G, Richard Bates, C, Mair, James M, Saunders, Graham R, Harries, Dan B, Lyndon, Alastair R

“…1.This study describes investigations into mapping of the biogenic reefs produced by the polychaete worm, Serpula vermicularis, for the purposes of…”
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Colorectal Cancer Progression: Integrin alphavbeta6 and the Epithelial-Mesenchymal Transition (EMT) by Bates, Richard C.

“…Carcinomas, those tumors that arise from epithelial tissues, represent the most prevalent form ofhuman malignancies. Moreover, it is the metastatic spread of…”
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The epithelial-mesenchymal transition (EMT) and colorectal cancer progression by Bates, Richard C, Mercurio, Arthur M

“…During embryonic development, epithelial cells must escape the structural constraints imposed by tissue architecture and adopt a phenotype more amenable to…”
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Tumor necrosis factor-alpha stimulates the epithelial-to-mesenchymal transition of human colonic organoids by Bates, Richard C, Mercurio, Arthur M

“…An epithelial-mesenchymal transition (EMT) characterizes the progression of many carcinomas and it is linked to the acquisition of an invasive phenotype. Given…”
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A rat retinal damage model predicts for potential clinical visual disturbances induced by Hsp90 inhibitors by Zhou, Dan, Liu, Yuan, Ye, Josephine, Ying, Weiwen, Ogawa, Luisa Shin, Inoue, Takayo, Tatsuta, Noriaki, Wada, Yumiko, Koya, Keizo, Huang, Qin, Bates, Richard C., Sonderfan, Andrew J.

“…In human trials certain heat shock protein 90 (Hsp90) inhibitors, including 17-DMAG and NVP-AUY922, have caused visual disorders indicative of retinal…”
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Geophysical Investigation of the Neolithic Calanais Landscape by Bates, C. Richard, Bates, Martin, Gaffney, Chris, Gaffney, Vincent, Raub, Timothy D.

“…The northern and western isles of Scotland have proved fertile ground for archaeological investigation over the last 100 years. However, the nature of the…”
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Preclinical Activity Profile and Therapeutic Efficacy of the HSP90 Inhibitor Ganetespib in Triple-Negative Breast Cancer by PROIA, David A, CHAOHUA ZHANG, SMITH, Donald L, SANG, Jim, BATES, Richard C, EL-HARIRY, Iman, SEQUEIRA, Manuel, JIMENEZ, John-Paul, SUQIN HE, SPECTOR, Neil, SHAPIRO, Geoffrey I, TOLANEY, Sara, NAGAI, Masazumi, ACQUAVIVA, Jaime

“…Treatment options for patients with triple-negative breast cancer (TNBC) are largely limited to systemic chemotherapies, which have shown disappointing…”
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