Search Results - "Richard A. O. Bennett"

Base Excision Repair in Early Zebrafish Development: Evidence for DNA Polymerase Switching and Standby AP Endonuclease Activity by Fortier, Sean, Yang, Xiaojie, Wang, Yi, Bennett, Richard A. O, Strauss, Phyllis R

“…The base excision repair (BER) pathway recognizes and repairs most nonbulky lesions, uracil and abasic (AP) sites in DNA. Several participants are embryonic…”
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Mutagenic specificity of endogenously generated abasic sites in Saccharomyces cerevisiae chromosomal DNA by Auerbach, P, Bennett, R.A.O, Bailey, E.A, Krokan, H.E, Demple, B

“…Abasic [apurinic/apyrimidinic (AP)] sites are common, noncoding DNA lesions. Despite extensive investigation, the mutational pattern they provoke in eukaryotic…”
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A method for high‐throughput production of sequence‐verified DNA libraries and strain collections by Smith, Justin D, Schlecht, Ulrich, Xu, Weihong, Suresh, Sundari, Horecka, Joe, Proctor, Michael J, Aiyar, Raeka S, Bennett, Richard A O, Chu, Angela, Li, Yong Fuga, Roy, Kevin, Davis, Ronald W, Steinmetz, Lars M, Hyman, Richard W, Levy, Sasha F, St.Onge, Robert P

“…The low costs of array‐synthesized oligonucleotide libraries are empowering rapid advances in quantitative and synthetic biology. However, high synthesis error…”
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Interaction of Human Apurinic Endonuclease and DNA Polymerase β in the Base Excision Repair Pathway by Richard A. O. Bennett, Wilson, David M., Wong, Donny, Demple, Bruce

“…Mutagenic abasic (AP) sites are generated directly by DNA-damaging agents or by DNA glycosylases acting in base excision repair. AP sites are corrected via…”
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The Saccharomyces cerevisiae ETH1 Gene, an Inducible Homolog of Exonuclease III That Provides Resistance to DNA-Damaging Agents and Limits Spontaneous Mutagenesis by Bennett, Richard A. O.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Single-Turnover Analysis of Mutant Human Apurinic/Apyrimidinic Endonuclease by Lucas, Julie A, Masuda, Yuji, Bennett, Richard A. O, Strauss, Nathaniel S, Strauss, Phyllis R

“…Apurinic/apyrimidinic endonuclease (AP endo) is a key enzyme in the repair of oxidatively damaged DNA. Using single-turnover conditions, we recently described…”
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Thermolabile adenine adducts and A.cntdot.T base pair substitutions induced by nitrogen mustard analogs in an SV40-based shuttle plasmid by Wang, Peng, Bauer, Gwen B, Bennett, Richard A. O, Povirk, Lawrence F

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INDIVIDUAL VARIABILITY IN THE ZINC INDUCIBILITY OF METALLOTHIONEIN-IIA mRNA IN HUMAN LYMPHOCYTES by Wu, Ming-Tsang, Demple, Bruce, Bennett, Richard A. O., Christiani, David C., Fan, Rong, Hu, Howard

“…The metallothionein-II A gene (MT-II A ) is a major member of the human MT gene family. Metallothioneins (MTs) are low-molecular-weight, cysteine-rich proteins…”
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Spontaneous cleavage of bleomycin-induced abasic sites in chromatin and their mutagenicity in mammalian shuttle vectors by Bennett, Richard A. O, Swerdlow, Paul S, Povirk, Lawrence F

“…The stability of oxidized abasic sites induced by bleomycin and neocarzinostatin was examined in chromatin reconstituted from a supercoiled plasmid and core…”
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Dynamics of the Interaction of Human Apurinic Endonuclease (Ape1) with Its Substrate and Product by Masuda, Yuji, Bennett, Richard A.O., Demple, Bruce

“…We investigated the interaction dynamics of human abasic endonuclease, the Ape1 protein (also called Ref1, Hap1, or Apex), with its DNA substrate and incised…”
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Rapid Dissociation of Human Apurinic Endonuclease (Ape1) from Incised DNA Induced by Magnesium by Masuda, Yuji, Bennett, Richard A.O., Demple, Bruce

“…Repair of apurinic/apyrimidinic (AP) sites is initiated by AP endonucleases, such as the human Ape1 protein (also called Hap1, Apex, and Ref1). This and…”
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Key Role of a Downstream Specificity Protein 1 Site in Cell Cycle-regulated Transcription of the AP Endonuclease GeneAPE1/APEX in NIH3T3 Cells by Hua Fung, Richard A. O. Bennett, Bruce Demple

“…Abasic (apurinic/apyrimidinic or AP) sites are a frequent type of DNA damage that threatens genetic stability. The predominant mammalian enzyme initiating…”
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INDIVIDUAL VARIABILITY IN THE ZINC INDUCIBILITY OF METALLOTHIONEIN-II A mRNA IN HUMAN LYMPHOCYTES by Wu, Ming-Tsang, Demple, Bruce, Bennett, Richard A. O., Christiani, David C., Fan, Rong, Hu, Howard

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End-joining of Free Radical-mediated DNA Double-strand Breaks in Vitro Is Blocked by the Kinase Inhibitor Wortmannin at a Step Preceding Removal of Damaged 3′ Termini by Xiao-Yan Gu, Richard A. O. Bennett, Lawrence F. Povirk

“…Both mammalian cells and Xenopus eggs possess activities for the joining of nonhomologous DNA ends, and such activities may play a major role in double-strand…”
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Regulation of Eukaryotic Abasic Endonucleases and Their Role in Genetic Stability by Demple, Bruce, Harrison, Lynn, Wilson, David M., Bennett, Richard A. O., Takagi, Toshimitsu, Ascione, A. Gian

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Regulation of Eukaryotic Abasic Endonucleases and Their Role in Genetic Stability by Demple, Bruce, Harrison, Lynn, Wilson, David M., Richard A. O. Bennett, Takagi, Toshimitsu, Ascione, A. Gian

“…Abasic (AP) sites in DNA arise from spontaneous reactions or the action of DNA glycosylases and represent a loss of genetic information. The AP sites can be…”
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Individual Variability in the Zinc Inducibility of Metallothionein-II sub(A) mRNA in Human Lymphocytes by Wu, Ming-Tsang, Demple, Bruce, Bennett, Richard AO, Christiani, David C, Fan, Rong, Hu, Howard

“…Human lymphocytes were collected from 16 healthy subjects, and interindividual variability of metallothionein (MT)-II sub(A) mRNA expression was examined in…”
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