Search Results - "Richard A. Gardner"

High-throughput Serum N-Glycomics: Method Comparison and Application to Study Rheumatoid Arthritis and Pregnancy-associated Changes[S] by Reiding, Karli R., Bondt, Albert, Hennig, René, Gardner, Richard A., O'Flaherty, Roisin, Trbojević-Akmačić, Irena, Shubhakar, Archana, Hazes, Johanna M.W., Reichl, Udo, Fernandes, Daryl L., Pučić-Baković, Maja, Rapp, Erdmann, Spencer, Daniel I.R., Dolhain, Radboud J.E.M., Rudd, Pauline M., Lauc, Gordan, Wuhrer, Manfred

“…N-Glycosylation is a fundamentally important protein modification with a major impact on glycoprotein characteristics such as serum half-life and receptor…”
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Improved and semi-automated reductive β-elimination workflow for higher throughput protein O-glycosylation analysis by Kotsias, Maximilianos, Kozak, Radoslaw P, Gardner, Richard A, Wuhrer, Manfred, Spencer, Daniel I R

“…Protein O-glycosylation has shown to be critical for a wide range of biological processes, resulting in an increased interest in studying the alterations in…”
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Sialylation on O-linked glycans protects von Willebrand factor from macrophage galactose lectin-mediated clearance by Ward, Soracha E, O'Sullivan, Jamie M, Moran, Alan B, Spencer, Daniel I R, Gardner, Richard A, Sharma, Jyotika, Fazavana, Judicael, Monopoli, Marco, McKinnon, Thomas A J, Chion, Alain, Haberichter, Sandra, O'Donnell, James S

“…Terminal sialylation determines the plasma half-life of von Willebrand factor (VWF). A role for macrophage galactose lectin (MGL) in regulating hyposialylated…”
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High-Throughput Analysis and Automation for Glycomics Studies by Shubhakar, Archana, Reiding, Karli R, Gardner, Richard A, Spencer, Daniel I. R, Fernandes, Daryl L, Wuhrer, Manfred

“…This review covers advances in analytical technologies for high-throughput (HTP) glycomics. Our focus is on structural studies of glycoprotein glycosylation to…”
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Generation and Characterization of Native and Sialic Acid-Deficient IgE by McCraw, Alex J., Gardner, Richard A., Davies, Anna M., Spencer, Daniel I. R., Grandits, Melanie, Wagner, Gerd K., McDonnell, James M., Karagiannis, Sophia N., Chenoweth, Alicia, Crescioli, Silvia

“…Efficient characterization of IgE antibodies and their glycan structures is required for understanding their function in allergy and in the emerging…”
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Protein O-glycosylation analysis by Zauner, Gerhild, Kozak, Radoslaw P, Gardner, Richard A, Fernandes, Daryl L, Deelder, André M, Wuhrer, Manfred

“…This review provides an overview on the methods available for analysis of O-glycosylation. Three major themes are addressed: analysis of released O-glycans…”
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L1CAM as an E-selectin Ligand in Colon Cancer by Deschepper, Fanny M, Zoppi, Roberta, Pirro, Martina, Hensbergen, Paul J, Dall'Olio, Fabio, Kotsias, Maximillianos, Gardner, Richard A, Spencer, Daniel I R, Videira, Paula A

“…Metastasis is the main cause of death among colorectal cancer (CRC) patients. E-selectin and its carbohydrate ligands, including sialyl Lewis X (sLe ) antigen,…”
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Suppression of peeling during the release of O-glycans by hydrazinolysis by Kozak, Radoslaw P., Royle, Louise, Gardner, Richard A., Fernandes, Daryl L., Wuhrer, Manfred

“…The analysis of O-glycans is essential for better understanding their functions in biological processes. Although many techniques for O-glycan release have…”
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Tsetse salivary glycoproteins are modified with paucimannosidic N-glycans, are recognised by C-type lectins and bind to trypanosomes by Kozak, Radoslaw P, Mondragon-Shem, Karina, Williams, Christopher, Rose, Clair, Perally, Samirah, Caljon, Guy, Van Den Abbeele, Jan, Wongtrakul-Kish, Katherine, Gardner, Richard A, Spencer, Daniel, Lehane, Michael J, Acosta-Serrano, Álvaro

“…African sleeping sickness is caused by Trypanosoma brucei, a parasite transmitted by the bite of a tsetse fly. Trypanosome infection induces a severe…”
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Characterization of a sialate-O-acetylesterase (NanS) from the oral pathogen Tannerella forsythia that enhances sialic acid release by NanH, its cognate sialidase by Phansopa, Chatchawal, Kozak, Radoslaw P, Liew, Li Phing, Frey, Andrew M, Farmilo, Thomas, Parker, Jennifer L, Kelly, David J, Emery, Robert J, Thomson, Rebecca I, Royle, Louise, Gardner, Richard A, Spencer, Daniel I R, Stafford, Graham P

“…Tannerella forsythia, a Gram-negative member of the Bacteroidetes has evolved to harvest and utilize sialic acid. The most common sialic acid in humans is a…”
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Erythropoietin N -glycosylation of Therapeutic Formulations Quantified and Characterized: An Interlab Comparability Study of High-Throughput Methods by O'Flaherty, Róisín, Amez Martín, Manuela, Gardner, Richard A, Jennings, Patrick M, Rudd, Pauline M, Spencer, Daniel I R, Falck, David

“…Recombinant human erythropoietin (EPO) is a biopharmaceutical frequently used in the treatment of anemia. It is a heavily glycosylated protein with a diverse…”
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Glycoengineering of Therapeutic Antibodies with Small Molecule Inhibitors by Li, Shasha, McCraw, Alex J, Gardner, Richard A, Spencer, Daniel I R, Karagiannis, Sophia N, Wagner, Gerd K

“…Monoclonal antibodies (mAbs) are one of the cornerstones of modern medicine, across an increasing range of therapeutic areas. All therapeutic mAbs are…”
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A Matrix-Assisted Laser Desorption/Ionization-Mass Spectrometry Assay for the Relative Quantitation of Antennary Fucosylated N -Glycans in Human Plasma by Rebello, Osmond D, Nicolardi, Simone, Lageveen-Kammeijer, Guinevere S M, Nouta, Jan, Gardner, Richard A, Mesker, Wilma E, Tollenaar, Rob A E M, Spencer, Daniel I R, Wuhrer, Manfred, Falck, David

“…Changes in the abundance of antennary fucosylated glycans in human total plasma -glycome (TPNG) have been associated with several diseases ranging from…”
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Correction: changes to serum sample tube and processing methodology does not cause inter-individual variation in automated whole serum N-glycan profiling in health and disease by Ventham, Nicholas T, Gardner, Richard A, Kennedy, Nicholas A, Shubhakar, Archana, Kalla, Rahul, Nimmo, Elaine R, Fernandes, Daryl L, Satsangi, Jack, Spencer, Daniel I R

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Sialic Acid Derivatization of Fluorescently Labeled N‑Glycans Allows Linkage Differentiation by Reversed-Phase Liquid Chromatography–Fluorescence Detection–Mass Spectrometry by Moran, Alan B., Gardner, Richard A., Wuhrer, Manfred, Lageveen-Kammeijer, Guinevere S. M., Spencer, Daniel I. R.

“…Sialic acids have diverse biological roles, ranging from promoting up to preventing protein and cellular recognition in health and disease. The various…”
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Probing the glycans accessibility in the nanoparticle biomolecular corona by Clemente, Eva, Martinez-Moro, Marta, Trinh, Duong N, Soliman, Mahmoud G., Spencer, Daniel I R, Gardner, Richard A, Kotsias, Maximilianos, Sánchez Iglesias, Ana, Moya, Sergio, Monopoli, Marco P

“…[Display omitted] Following blood administration, the pristine surface of nanoparticles (NPs) associates with biomolecules from the surrounding environment…”
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Nanoparticle Biomolecular Corona-Based Enrichment of Plasma Glycoproteins for N‑Glycan Profiling and Application in Biomarker Discovery by Trinh, Duong N, Gardner, Richard A, Franciosi, Alessandro N, McCarthy, Cormac, Keane, Michael P, Soliman, Mahmoud G, O’Donnell, James S, Meleady, Paula, Spencer, Daniel I. R, Monopoli, Marco P

“…Biomolecular corona formation has emerged as a recurring and important phenomenon in nanomedicine that has been investigated for potential applications in…”
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N-glycan Characterization by Liquid Chromatography Coupled with Fluorimetry and Mass Spectrometry by Gardner, Richard A, Urbanowicz, Paulina A, Spencer, Daniel I R

“…Human blood plasma and serum have been a source of biomarkers for the indication and progression of many diseases for a few decades now. Human blood plasma is…”
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IgE glycosylation and impact on structure and function: A systematic review by McCraw, Alexandra J., Palhares, Lais C. G. F., Hendel, Jenifer L., Gardner, Richard A., Santaolalla, Aida, Crescioli, Silvia, McDonnell, James, Van Hemelrijck, Mieke, Chenoweth, Alicia, Spencer, Daniel I. R., Wagner, Gerd K., Karagiannis, Sophia N.

“…The impact of human IgE glycosylation on structure, function and disease mechanisms is not fully elucidated, and heterogeneity in different studies renders…”
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Elevated concentrations of Neu5Ac and Neu5,9Ac2 in human plasma: potential biomarkers of cardiovascular disease by Cheeseman, Jack, Badia, Concepcion, Elgood-Hunt, Georgia, Gardner, Richard A., Trinh, Duong N., Monopoli, Marco P., Kuhnle, Gunter, Spencer, Daniel I.R., Osborn, Helen M.I.

“…Cardiovascular disease (CVD) is a group of health conditions affecting the heart and vascular system with very high prevalence and mortality rates. The…”
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