Search Results - "Richard, Mariadasse"

Characterization of the NiRAN domain from RNA-dependent RNA polymerase provides insights into a potential therapeutic target against SARS-CoV-2 by Dwivedy, Abhisek, Mariadasse, Richard, Ahmad, Mohammed, Chakraborty, Sayan, Kar, Deepsikha, Tiwari, Satish, Bhattacharyya, Sankar, Sonar, Sudipta, Mani, Shailendra, Tailor, Prafullakumar, Majumdar, Tanmay, Jeyakanthan, Jeyaraman, Biswal, Bichitra Kumar

“…Apart from the canonical fingers, palm and thumb domains, the RNA dependent RNA polymerases (RdRp) from the viral order Nidovirales possess two additional…”
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Investigation of vital pathogenic target orotate phosphoribosyltransferases (OPRTase) from Thermus thermophilus HB8: Phylogenetic and molecular modeling approach by Surekha, Kanagarajan, Prabhu, Damodharan, Richard, Mariadasse, Nachiappan, Mutharasappan, Biswal, Jayashree, Jeyakanthan, Jeyaraman

“…Biosynthesis pathways of pyrimidine and purine are shown to play an important role in regular cellular activities. The biosynthesis can occur either through de…”
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Repurposing of Doxycycline to Hinder the Viral Replication of SARS-CoV-2: From in silico to in vitro Validation by Alexpandi, Rajaiah, Gendrot, Mathieu, Abirami, Gurusamy, Delandre, Océane, Fonta, Isabelle, Mosnier, Joel, Mariadasse, Richard, Jeyakanthan, Jeyaraman, Pandian, Shunmugiah Karutha, Pradines, Bruno, Ravi, Arumugam Veera

“…Since the rapid spread of coronavirus disease (COVID-19) became a global pandemic, healthcare ministries around the world have recommended specific control…”
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Prediction of Small Molecule Inhibitors Targeting the Severe Acute Respiratory Syndrome Coronavirus‑2 RNA-dependent RNA Polymerase by Ahmad, Mohammed, Dwivedy, Abhisek, Mariadasse, Richard, Tiwari, Satish, Kar, Deepsikha, Jeyakanthan, Jeyaraman, Biswal, Bichitra K

“…The current COVID-19 outbreak warrants the design and development of novel anti-COVID therapeutics. Using a combination of bioinformatics and computational…”
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Structural snapshots of Mycobacterium tuberculosis enolase reveal dual mode of 2PG binding and its implication in enzyme catalysis by Ahmad, Mohammed, Jha, Bhavya, Bose, Sucharita, Tiwari, Satish, Dwivedy, Abhisek, Kar, Deepshikha, Pal, Ravikant, Mariadasse, Richard, Parish, Tanya, Jeyakanthan, Jeyaraman, Vinothkumar, Kutti R, Biswal, Bichitra Kumar

“…Enolase, a ubiquitous enzyme, catalyzes the reversible conversion of 2-phosphoglycerate (2PG) to phosphoenolpyruvate (PEP) in the glycolytic pathway of…”
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Insights into Exogenous Tryptophan-Mediated Allosteric Communication and Helical Transition of TRP Protein for Transcription Regulation by Mariadasse, Richard, Choubey, Sanjay Kumar, Jeyakanthan, Jeyaraman

“…In this study, the binding recognition and allosteric mechanism of tryptophan-responsive regulatory protein (TRP)–DNA and bound exogenous tryptophan (Trp)…”
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Molecular evolution, binding site interpretation and functional divergence of aspartate semialdehyde dehydrogenase by Amala, Mathimaran, Richard, Mariadasse, Saritha, Poopandi, Prabhu, Dhamodharan, Veerapandiyan, Malaisamy, Surekha, Kangarajan, Jeyakanthan, Jeyaraman

“…Aspartate Semialdehyde Dehydrogenase (ASDH) is an important enzyme essential for the viability of pathogenic microorganisms. ASDH is mainly involved in amino…”
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Identification of novel histone deacetylase 1 inhibitors by combined pharmacophore modeling, 3D-QSAR analysis, in silico screening and Density Functional Theory (DFT) approaches by Choubey, Sanjay K., Mariadasse, Richard, Rajendran, Santhosh, Jeyaraman, Jeyakanthan

“…Overexpression of HDAC1, a member of Class I histone deacetylase is reported to be implicated in breast cancer. Epigenetic alteration in carcinogenesis has…”
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Integrated spectroscopic and MD simulation approach to decipher the effect of pH on the structure function of Staphylococcus aureus thymidine kinase by Ashraf, Anam, Ahmad, Mohammad, Mariadasse, Richard, Khan, Monis Ali, Noor, Saba, Islam, Asimul, Hassan, Md Imtaiyaz

“…is a major human pathogen responsible for a variety of clinical infections, becoming increasingly resistant to antibiotics. To address this challenge, there is…”
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Characterization of putative transcriptional regulator (PH0140) and its distal homologue by Mariadasse, Richard, Rajmichael, Raji, Dwivedy, Abhisek, Amala, Mathimaran, Ahmad, Mohammed, Mutharasappan, Nachiappan, Biswal, Bichitra K., Jeyakanthan, Jeyaraman

“…In this study, a phylogenetic tree was constructed using 1854 sequences of various Lrp/AnsC (FFRPs) and ArsR proteins from pathogenic and non-pathogenic…”
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Structural and functional insights of STAT2-NS5 interaction for the identification of NS5 antagonist – An approach for restoring interferon signaling by Choubey, Sanjay Kumar, Nachiappan, Mutharasappan, Richard, Mariadasse, Chitra, Jeyaraj Pandian, Jeyakanthan, Jeyaraman

“…[Display omitted] •Protein-protein interaction of NS5-STAT2 complex playing major role in signaling mechanism for Dengue infection.•The binding mode and…”
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In silico evaluation of isatin-based derivatives with RNA-dependent RNA polymerase of the novel coronavirus SARS-CoV-2 by M., Rajesh Kumar, Gideon, Daniel A., Mariadasse, Richard, Nirusimhan, Vijay, A., Sherlin Rosita, Edward, Jesu Castin, Jeyaraman, Jeyakanthan, Dhayabaran, Violet

“…Isatin (1H-indole-2,3-dione)-containing compounds have been shown to possess several remarkable biological activities. We had previously explored a few…”
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Structural snapshots of Mycobacterium tuberculosis enolase during the reverse reaction reveal dual mode of 2PG binding and its implication in enzyme catalysis by Ahmad, Mohammed, Jha, Bhavya, Bose, Sucharita, Tiwari, Satish, Dwivedy, Abhisek, Kar, Deepshikha, Pal, Ravikant, Mariadasse, Richard, Parish, Tanya, Jayekanthan, Jeyaraman, Vinothkumar, Kutti Ragunath, Biswal, Bichitra Kumar

“…Abstract only…”
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Mechanical insights of oxythiamine compound as potent inhibitor for human transketolase-like protein 1 (TKTL1 protein) by Mariadasse, Richard, Biswal, Jayashree, Jayaprakash, Prajisha, Rao, Guru Raj, Choubey, Sanjay Kumar, Rajendran, Santhosh, Jeyakanthan, Jeyaraman

“…Transketolase is a connecting link between glycolytic and pentose phosphate pathway, which is considered as the rate-limiting step due to synthesis of large…”
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Insights from the Molecular modeling, docking analysis of illicit drugs and Bomb Compounds with Honey Bee Odorant Binding Proteins (OBPs) by Langeswaran, Kulanthaivel, Jeyaraman, Jeyakanthan, Mariadasse, Richard, Soorangkattan, Saravanan

“…Analysis of honeybee PBPs is of interest in the development of Biosensor applications. We described the predicted binding of 19 such compounds with 43-honey…”
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