Search Results - "Rich, Jeremy N"

Cancer Stem Cells: The Architects of the Tumor Ecosystem by Prager, Briana C., Xie, Qi, Bao, Shideng, Rich, Jeremy N.

“…Cancer stem cells (CSCs) proactively remodel their microenvironment to maintain a supportive niche. Viewed through the lens of an ecosystem, numerous tumor…”
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Glioblastoma stem cells: lessons from the tumor hierarchy in a lethal cancer by Gimple, Ryan C, Bhargava, Shruti, Dixit, Deobrat, Rich, Jeremy N

“…Glioblastoma ranks among the most lethal of all human cancers. Glioblastomas display striking cellular heterogeneity, with stem-like glioblastoma stem cells…”
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Cancer stem cells in radiation resistance by RICH, Jeremy N

“…Highly tumorigenic subpopulations of several solid cancers share characteristics with somatic stem cells. We showed recently that cancer stem cells, or…”
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Glioblastoma Stem Cells Generate Vascular Pericytes to Support Vessel Function and Tumor Growth by Cheng, Lin, Huang, Zhi, Zhou, Wenchao, Wu, Qiulian, Donnola, Shannon, Liu, James K., Fang, Xiaoguang, Sloan, Andrew E., Mao, Yubin, Lathia, Justin D., Min, Wang, McLendon, Roger E., Rich, Jeremy N., Bao, Shideng

“…Glioblastomas (GBMs) are highly vascular and lethal brain tumors that display cellular hierarchies containing self-renewing tumorigenic glioma stem cells…”
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Cancer stem cells in glioblastoma by Lathia, Justin D, Mack, Stephen C, Mulkearns-Hubert, Erin E, Valentim, Claudia L L, Rich, Jeremy N

“…Tissues with defined cellular hierarchies in development and homeostasis give rise to tumors with cellular hierarchies, suggesting that tumors recapitulate…”
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Survival of the Fittest: Cancer Stem Cells in Therapeutic Resistance and Angiogenesis by Eyler, Christine E, Rich, Jeremy N

“…In an increasing number of cancers, tumor populations called cancer stem cells (CSCs), or tumor-initiating cells, have been defined in functional assays of…”
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Phosphorylation of EZH2 Activates STAT3 Signaling via STAT3 Methylation and Promotes Tumorigenicity of Glioblastoma Stem-like Cells by Kim, Eunhee, Kim, Misuk, Woo, Dong-Hun, Shin, Yongjae, Shin, Jihye, Chang, Nakho, Oh, Young Taek, Kim, Hong, Rheey, Jingeun, Nakano, Ichiro, Lee, Cheolju, Joo, Kyeung Min, Rich, Jeremy N., Nam, Do-Hyun, Lee, Jeongwu

“…Glioblastoma multiforme (GBM) displays cellular hierarchies harboring a subpopulation of stem-like cells (GSCs). Enhancer of Zeste Homolog 2 (EZH2), the lysine…”
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Brain cancer stem cells: resilience through adaptive plasticity and hierarchical heterogeneity by Gimple, Ryan C., Yang, Kailin, Halbert, Matthew E., Agnihotri, Sameer, Rich, Jeremy N.

“…Malignant brain tumours are complex ecosystems containing neoplastic and stromal components that generate adaptive and evolutionarily driven aberrant tissues…”
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A Three-Dimensional Organoid Culture System Derived from Human Glioblastomas Recapitulates the Hypoxic Gradients and Cancer Stem Cell Heterogeneity of Tumors Found In Vivo by Hubert, Christopher G, Rivera, Maricruz, Spangler, Lisa C, Wu, Qiulian, Mack, Stephen C, Prager, Briana C, Couce, Marta, McLendon, Roger E, Sloan, Andrew E, Rich, Jeremy N

“…Many cancers feature cellular hierarchies that are driven by tumor-initiating cancer stem cells (CSC) and rely on complex interactions with the tumor…”
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Deadly Teamwork: Neural Cancer Stem Cells and the Tumor Microenvironment by Lathia, Justin D., Heddleston, John M., Venere, Monica, Rich, Jeremy N.

“…Neural cancers display cellular hierarchies with self-renewing tumorigenic cancer stem cells (CSCs) at the apex. Instructive cues to maintain CSCs are…”
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Functional Enhancers Shape Extrachromosomal Oncogene Amplifications by Morton, Andrew R., Dogan-Artun, Nergiz, Faber, Zachary J., MacLeod, Graham, Bartels, Cynthia F., Piazza, Megan S., Allan, Kevin C., Mack, Stephen C., Wang, Xiuxing, Gimple, Ryan C., Wu, Qiulian, Rubin, Brian P., Shetty, Shashirekha, Angers, Stephane, Dirks, Peter B., Sallari, Richard C., Lupien, Mathieu, Rich, Jeremy N., Scacheri, Peter C.

“…Non-coding regions amplified beyond oncogene borders have largely been ignored. Using a computational approach, we find signatures of significant…”
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Glioma Stem Cell Proliferation and Tumor Growth Are Promoted by Nitric Oxide Synthase-2 by Eyler, Christine E., Wu, Qiulian, Yan, Kenneth, MacSwords, Jennifer M., Chandler-Militello, Devin, Misuraca, Katherine L., Lathia, Justin D., Forrester, Michael T., Lee, Jeongwu, Stamler, Jonathan S., Goldman, Steven A., Bredel, Markus, McLendon, Roger E., Sloan, Andrew E., Hjelmeland, Anita B., Rich, Jeremy N.

“…Malignant gliomas are aggressive brain tumors with limited therapeutic options, and improvements in treatment require a deeper molecular understanding of this…”
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Preferential Iron Trafficking Characterizes Glioblastoma Stem-like Cells by Schonberg, David L., Miller, Tyler E., Wu, Qiulian, Flavahan, William A., Das, Nupur K., Hale, James S., Hubert, Christopher G., Mack, Stephen C., Jarrar, Awad M., Karl, Robert T., Rosager, Ann Mari, Nixon, Anne M., Tesar, Paul J., Hamerlik, Petra, Kristensen, Bjarne W., Horbinski, Craig, Connor, James R., Fox, Paul L., Lathia, Justin D., Rich, Jeremy N.

“…Glioblastomas display hierarchies with self-renewing cancer stem-like cells (CSCs). RNA sequencing and enhancer mapping revealed regulatory programs unique to…”
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The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype by Heddleston, John M., Li, Zhizhong, McLendon, Roger E., Hjelmeland, Anita B., Rich, Jeremy N.

“…Glioblastomas are highly lethal cancers that contain cellular hierarchies with self-renewing cancer stem cells that can propagate tumors in secondary…”
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Epitranscriptomic editing of the RNA N6-methyladenosine modification by dCasRx conjugated methyltransferase and demethylase by Xia, Zhen, Tang, Min, Ma, Jiayan, Zhang, Hongyan, Gimple, Ryan C, Prager, Briana C, Tang, Hongzhen, Sun, Chongran, Liu, Fuyi, Lin, Peng, Mei, Yutang, Du, Ruoxin, Rich, Jeremy N, Xie, Qi

“…Abstract N6-methyladenosine (m6A) is a common modification on endogenous RNA transcripts in mammalian cells. Technologies to precisely modify the RNA m6A…”
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Dual Role of WISP1 in maintaining glioma stem cells and tumor-supportive macrophages in glioblastoma by Tao, Weiwei, Chu, Chengwei, Zhou, Wenchao, Huang, Zhi, Zhai, Kui, Fang, Xiaoguang, Huang, Qian, Zhang, Aili, Wang, Xiuxing, Yu, Xingjiang, Huang, Haidong, Wu, Qiulian, Sloan, Andrew E., Yu, Jennifer S., Li, Xiaoxia, Stark, George R., Rich, Jeremy N., Bao, Shideng

“…The interplay between glioma stem cells (GSCs) and the tumor microenvironment plays crucial roles in promoting malignant growth of glioblastoma (GBM), the most…”
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Potential therapeutic implications of cancer stem cells in glioblastoma by Cheng, Lin, Bao, Shideng, Rich, Jeremy N.

“…Glioblastoma is the most common and lethal type of primary brain tumor. Despite recent therapeutic advances in other cancers, the treatment of glioblastomas…”
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Mitochondrial control by DRP1 in brain tumor initiating cells by Xie, Qi, Wu, Qiulian, Horbinski, Craig M, Flavahan, William A, Yang, Kailin, Zhou, Wenchao, Dombrowski, Stephen M, Huang, Zhi, Fang, Xiaoguang, Shi, Yu, Ferguson, Ashley N, Kashatus, David F, Bao, Shideng, Rich, Jeremy N

“…Glioblastomas contains stem-like tumor cells that display differential metabolic profiles. Here the authors show that brain tumor initiating cells contain…”
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AMPK/FIS1-Mediated Mitophagy Is Required for Self-Renewal of Human AML Stem Cells by Pei, Shanshan, Minhajuddin, Mohammad, Adane, Biniam, Khan, Nabilah, Stevens, Brett M., Mack, Stephen C., Lai, Sisi, Rich, Jeremy N., Inguva, Anagha, Shannon, Kevin M., Kim, Hyunmin, Tan, Aik-Choon, Myers, Jason R., Ashton, John M., Neff, Tobias, Pollyea, Daniel A., Smith, Clayton A., Jordan, Craig T.

“…Leukemia stem cells (LSCs) are thought to drive the genesis of acute myeloid leukemia (AML) as well as relapse following chemotherapy. Because of their unique…”
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High-speed coherent Raman fingerprint imaging of biological tissues by Camp Jr, Charles H., Lee, Young Jong, Heddleston, John M., Hartshorn, Christopher M., Walker, Angela R. Hight, Rich, Jeremy N., Lathia, Justin D., Cicerone, Marcus T.

“…An imaging platform based on broadband coherent anti-Stokes Raman scattering has been developed that provides an advantageous combination of speed, sensitivity…”
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