Search Results - "Rice, Margaret E"

Insulin enhances striatal dopamine release by activating cholinergic interneurons and thereby signals reward by Stouffer, Melissa A., Woods, Catherine A., Patel, Jyoti C., Lee, Christian R., Witkovsky, Paul, Bao, Li, Machold, Robert P., Jones, Kymry T., de Vaca, Soledad Cabeza, Reith, Maarten E. A., Carr, Kenneth D., Rice, Margaret E.

“…Insulin activates insulin receptors (InsRs) in the hypothalamus to signal satiety after a meal. However, the rising incidence of obesity, which results in…”
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Activity-dependent somatodendritic dopamine release in the substantia nigra autoinhibits the releasing neuron by Hikima, Takuya, Lee, Christian R., Witkovsky, Paul, Chesler, Julia, Ichtchenko, Konstantin, Rice, Margaret E.

“…Somatodendritic dopamine (DA) release from midbrain DA neurons activates D2 autoreceptors on these cells to regulate their activity. However, the source of…”
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Glutamatergic signaling by mesolimbic dopamine neurons in the nucleus accumbens by Tecuapetla, Fatuel, Patel, Jyoti C, Xenias, Harry, English, Daniel, Tadros, Ibrahim, Shah, Fulva, Berlin, Joshua, Deisseroth, Karl, Rice, Margaret E, Tepper, James M, Koos, Tibor

“…Recent evidence suggests the intriguing possibility that midbrain dopaminergic (DAergic) neurons may use fast glutamatergic transmission to communicate with…”
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Nicotine amplifies reward-related dopamine signals in striatum by Cragg, Stephanie J, Rice, Margaret E

“…Reward-seeking behaviors depend critically on dopamine signaling-dopamine neurons encode reward-related information by switching from tonic to phasic…”
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GABA co-released from striatal dopamine axons dampens phasic dopamine release through autoregulatory GABAA receptors by Patel, Jyoti C., Sherpa, Ang D., Melani, Riccardo, Witkovsky, Paul, Wiseman, Madeline R., O’Neill, Brian, Aoki, Chiye, Tritsch, Nicolas X., Rice, Margaret E.

“…Striatal dopamine axons co-release dopamine and gamma-aminobutyric acid (GABA), using GABA provided by uptake via GABA transporter-1 (GAT1). Functions of GABA…”
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Actions and Consequences of Insulin in the Striatum by Patel, Jyoti C, Carr, Kenneth D, Rice, Margaret E

“…Insulin crosses the blood-brain barrier to enter the brain from the periphery. In the brain, insulin has well-established actions in the hypothalamus, as well…”
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Opposing regulation of dopaminergic activity and exploratory motor behavior by forebrain and brainstem cholinergic circuits by Patel, Jyoti C., Rossignol, Elsa, Rice, Margaret E., Machold, Robert P.

“…Dopamine transmission is critical for exploratory motor behaviour. A key regulator is acetylcholine; forebrain acetylcholine regulates striatal dopamine…”
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Ascorbate regulation and its neuroprotective role in the brain by Rice, Margaret E.

“…Ascorbic acid (vitamin C) occurs physiologically as the ascorbate anion: a water-soluble antioxidant that is found throughout the body. However, despite the…”
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TRPM2 Channels Are Required for NMDA-Induced Burst Firing and Contribute to H2O2-Dependent Modulation in Substantia Nigra Pars Reticulata GABAergic Neurons by Lee, Christian R, Machold, Robert P, Witkovsky, Paul, Rice, Margaret E

“…Substantia nigra pars reticulata (SNr) GABAergic neurons are projection neurons that convey output from the basal ganglia to target structures. These neurons…”
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A Novel Transgenic Mouse Model to Investigate the Cell-Autonomous Effects of torsinA(ΔE) Expression in Striatal Output Neurons by Gonzalez-Alegre, Pedro, Beauvais, Genevieve, Martin, Janine, Koch, Rick J., Walker, Ruth H., Patel, Jyoti C., Rice, Margaret E., Ehrlich, Michelle E.

“…•Transgenic expression of torsinA(WT or ΔE) in striatal medium spiny neurons does not alter baseline mouse motor behavior.•D9.torsinA(WT) transgenic mice have…”
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Mobilization of Calcium from Intracellular Stores Facilitates Somatodendritic Dopamine Release by Patel, Jyoti C, Witkovsky, Paul, Avshalumov, Marat V, Rice, Margaret E

“…Somatodendritic dopamine (DA) release in the substantia nigra pars compacta (SNc) shows a limited dependence on extracellular calcium concentration…”
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Seeing a Tree Within the Forest: Selective Detection and Function of Somatodendritic Cholecystokinin Release From Dopamine Neurons in the Ventral Tegmental Area by Rice, Margaret E

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Activation of ATP-sensitive K+ (KATP) channels by H2O2 underlies glutamate-dependent inhibition of striatal dopamine release by Avshalumov, Marat V, Rice, Margaret E

“…In many cells, ATP-sensitive K + channels (K ATP channels) couple metabolic state to excitability. In pancreatic beta cells, for example, this coupling…”
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Cell-autonomous alteration of dopaminergic transmission by wild type and mutant (ΔE) TorsinA in transgenic mice by Page, Michelle E, Bao, Li, Andre, Pierrette, Pelta-Heller, Joshua, Sluzas, Emily, Gonzalez-Alegre, Pedro, Bogush, Alexey, Khan, Loren E, Iacovitti, Lorraine, Rice, Margaret E, Ehrlich, Michelle E

“…Abstract Early onset torsion dystonia is an autosomal dominant movement disorder of variable penetrance caused by a glutamic acid, i.e. ΔE, deletion in DYT1 ,…”
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H2O2: A Dynamic Neuromodulator by Rice, Margaret E.

“…Increasing evidence implicates hydrogen peroxide (H2O2) as an intracellular and intercellular signaling molecule that can influence processes from embryonic…”
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Endogenous Hydrogen Peroxide Regulates the Excitability of Midbrain Dopamine Neurons via ATP-Sensitive Potassium Channels by Avshalumov, Marat V, Chen, Billy T, Koos, Tibor, Tepper, James M, Rice, Margaret E

“…ATP-sensitive K+ (K(ATP)) channels link metabolic state to cell excitability. Here, we examined regulation of K(ATP) channels in substantia nigra dopamine…”
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Closing in on what motivates motivation by Rice, Margaret E.

“…The neurotransmitter dopamine facilitates learning, motivation and movement. Evidence of its release independently of the activity of dopamine-producing…”
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Striatal dopamine neurotransmission: Regulation of release and uptake by Sulzer, David, Cragg, Stephanie J., Rice, Margaret E.

“…Dopamine (DA) transmission is governed by processes that regulate release from axonal boutons in the forebrain and the somatodendritic compartment in midbrain,…”
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Inhibition of striatal dopamine release by CB1 receptor activation requires nonsynaptic communication involving GABA, H2O2, and KATP channels by Sidló, Zsuzsanna, Reggio, Patricia H., Rice, Margaret E.

“…The main psychoactive component of marijuana, Δ9-tetrahydrocannabinol (THC), acts in the CNS via type 1 cannabinoid receptors (CB1Rs). The behavioral…”
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Somatodendritic dopamine release: recent mechanistic insights by Rice, Margaret E., Patel, Jyoti C.

“…Dopamine (DA) is a key transmitter in motor, reward and cogitative pathways, with DA dysfunction implicated in disorders including Parkinson's disease and…”
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