Search Results - "Rice, Lisa M."

Single Cell RNA Sequencing Identifies HSPG2 and APLNR as Markers of Endothelial Cell Injury in Systemic Sclerosis Skin by Apostolidis, Sokratis A, Stifano, Giuseppina, Tabib, Tracy, Rice, Lisa M, Morse, Christina M, Kahaleh, Bashar, Lafyatis, Robert

“…The mechanisms that lead to endothelial cell (EC) injury and propagate the vasculopathy in Systemic Sclerosis (SSc) are not well understood. Using single cell…”
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Chronic Toll-like receptor 4 stimulation in skin induces inflammation, macrophage activation, transforming growth factor beta signature gene expression, and fibrosis by Stifano, Giuseppina, Affandi, Alsya J, Mathes, Allison L, Rice, Lisa M, Nakerakanti, Sashidhar, Nazari, Banafsheh, Lee, Jungeun, Christmann, Romy B, Lafyatis, Robert

“…The crucial role of innate immunity in the pathogenesis of systemic sclerosis (SSc) is well established, and in the past few years the hypothesis that…”
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Correction: Serum biomarker for diagnostic evaluation of pulmonary arterial hypertension in systemic sclerosis by Rice, Lisa M, Mantero, Julio C, Stratton, Eric A, Warburton, Rod, Roberts, Kari, Hill, Nicholas, Simms, Robert W, Domsic, Robyn, Farber, Harrison W, Lafyatis, Robert

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A Proteome-Derived Longitudinal Pharmacodynamic Biomarker for Diffuse Systemic Sclerosis Skin by Rice, Lisa M., Mantero, Julio C., Stifano, Giuseppina, Ziemek, Jessica, Simms, Robert W., Gordon, Jessica, Domsic, Robyn, Lafyatis, Robert

“…In this study we systematically investigated alterations in the serum proteome of patients with diffuse cutaneous systemic sclerosis and identified…”
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Serum biomarker for diagnostic evaluation of pulmonary arterial hypertension in systemic sclerosis by Rice, Lisa M, Mantero, Julio C, Stratton, Eric A, Warburton, Rod, Roberts, Kari, Hill, Nicholas, Simms, Robert W, Domsic, Robyn, Farber, Harrison W, Layfatis, Robert

“…Systemic sclerosis-associated pulmonary arterial hypertension (SSc-PAH) is one of the leading causes of death in SSc. Identification of a serum-based proteomic…”
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Promotion of Inflammatory Arthritis by Interferon Regulatory Factor 5 in a Mouse Model by Duffau, Pierre, Menn‐Josephy, Hanni, Cuda, Carla M., Dominguez, Salina, Aprahamian, Tamar R., Watkins, Amanda A., Yasuda, Kei, Monach, Paul, Lafyatis, Robert, Rice, Lisa M., Kenneth Haines, G., Gravallese, Ellen M., Baum, Rebecca, Richez, Christophe, Perlman, Harris, Bonegio, Ramon G., Rifkin, Ian R.

“…Objective Polymorphisms in the transcription factor interferon regulatory factor 5 (IRF5) are associated with an increased risk of developing rheumatoid…”
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Fresolimumab treatment decreases biomarkers and improves clinical symptoms in systemic sclerosis patients by Rice, Lisa M, Padilla, Cristina M, McLaughlin, Sarah R, Mathes, Allison, Ziemek, Jessica, Goummih, Salma, Nakerakanti, Sashidhar, York, Michael, Farina, Giuseppina, Whitfield, Michael L, Spiera, Robert F, Christmann, Romy B, Gordon, Jessica K, Weinberg, Janice, Simms, Robert W, Lafyatis, Robert

“…TGF-β has potent profibrotic activity in vitro and has long been implicated in systemic sclerosis (SSc), as expression of TGF-β-regulated genes is increased in…”
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Skin Gene Expression Is Prognostic for the Trajectory of Skin Disease in Patients With Diffuse Cutaneous Systemic Sclerosis by Stifano, Giuseppina, Sornasse, Thierry, Rice, Lisa M., Na, Leo, Chen‐Harris, Haiyin, Khanna, Dinesh, Jahreis, Angelika, Zhang, Yuqing, Siegel, Jeff, Lafyatis, Robert

“…Objective At present, there are no clinical or laboratory measures that accurately forecast the progression of skin fibrosis and organ involvement in patients…”
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A Longitudinal Biomarker for the Extent of Skin Disease in Patients With Diffuse Cutaneous Systemic Sclerosis by Rice, Lisa M., Ziemek, Jessica, Stratton, Eric A., McLaughlin, Sarah R., Padilla, Cristina M., Mathes, Allison L., Christmann, Romy B., Stifano, Giuseppina, Browning, Jeffrey L., Whitfield, Michael L., Spiera, Robert F., Gordon, Jessica K., Simms, Robert W., Zhang, Yuqing, Lafyatis, Robert

“…Objective To define a pharmacodynamic biomarker based on gene expression in skin that would provide a biologic measure of the extent of disease in patients…”
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Local skin gene expression reflects both local and systemic skin disease in patients with systemic sclerosis by Rice, Lisa M, Stifano, Giuseppina, Ziemek, Jessica, Lafyatis, Robert

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Messenger RNA rescues medium-chain acyl-CoA dehydrogenase deficiency in fibroblasts from patients and a murine model by Zhao, Xue-Jun, Mohsen, Al-Walid, Mihalik, Stephanie, Solo, Keaton, Basu, Shakuntala, Aliu, Ermal, Shi, Huifang, Kochersberger, Catherine, Karunanidhi, Anuradha, Van’t Land, Clinton, Coughlan, Kimberly A, Siddiqui, Summar, Rice, Lisa M, Hillier, Shawn, Guadagnin, Eleonora, DeAntonis, Christine, Giangrande, Paloma H, Martini, Paolo G V, Vockley, Jerry

“…Abstract Medium-chain acyl-CoA dehydrogenase (MCAD) deficiency is the most common inherited disorder of mitochondrial fatty acid β-oxidation (FAO) in humans…”
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Systemic modified messenger RNA for replacement therapy in alpha 1-antitrypsin deficiency by Karadagi, Ahmad, Cavedon, Alex G., Zemack, Helen, Nowak, Greg, Eybye, Marianne E., Zhu, Xuling, Guadagnin, Eleonora, White, Rebecca A., Rice, Lisa M., Frassetto, Andrea L., Strom, Stephen, Jorns, Carl, Martini, Paolo G. V., Ellis, Ewa

“…Alpha 1-antitrypsin (AAT) deficiency arises from an inherited mutation in the SERPINA1 gene. The disease causes damage in the liver where the majority of the…”
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Altered Dermal Fibroblasts in Systemic Sclerosis Display Podoplanin and CD90 by Nazari, Banafsheh, Rice, Lisa M, Stifano, Giuseppina, Barron, Alexander M.S, Wang, Yu M, Korndorf, Tess, Lee, Jungeun, Bhawan, Jag, Lafyatis, Robert, Browning, Jeffrey L

“…Tissue injury triggers the activation and differentiation of multiple cell types to minimize damage and initiate repair processes. In systemic sclerosis, these…”
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Synthetic mRNA rescues very long-chain acyl-CoA dehydrogenase deficiency in patient fibroblasts and a murine model by Zhao, Xue-Jun, Mohsen, AI-Walid, Mihalik, Stephanie, Solo, Keaton, Aliu, Ermal, Shi, Huifang, Basu, Shakuntala, Kochersperger, Catherine, Van’t Land, Clinton, Karunanidhi, Anuradha, Coughlan, Kimberly A., Siddiqui, Summar, Rice, Lisa M., Hillier, Shawn, Guadagnin, Eleonora, Giangrande, Paloma H., Martini, Paolo G.V., Vockley, Jerry

“…Very long-chain acyl-CoA dehydrogenase (VLCAD) deficiency is an inborn error of long chain fatty acid β-oxidation (FAO) with limited treatment options…”
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Fluorescent signatures for variable DNA sequences by Rice, John E, Reis, Jr, Arthur H, Rice, Lisa M, Carver-Brown, Rachel K, Wangh, Lawrence J

“…Life abounds with genetic variations writ in sequences that are often only a few hundred nucleotides long. Rapid detection of these variations for…”
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Design and Construction of a Single-Tube, LATE-PCR, Multiplex Endpoint Assay with Lights-On/Lights-Off Probes for the Detection of Pathogens Associated with Sepsis by Carver-Brown, Rachel K., Reis, Arthur H., Rice, Lisa M., Czajka, John W., Wangh, Lawrence J.

“…Aims. The goal of this study was to construct a single tube molecular diagnostic multiplex assay for the detection of microbial pathogens commonly associated…”
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Virtual Barcoding using LATE-PCR and Lights-On/Lights-Off probes: identification of nematode species in a closed-tube reaction by Rice, Lisa M, Reis, Jr, Arthur H, Wangh, Lawrence J

“…The present study describes a rapid, universal, easy-to-use, closed-tube, non-sequencing method that should also be able to uniquely identify almost any animal…”
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Interferon Regulatory Factor 5 Promotes Inflammatory Arthritis by Duffau, Pierre, Menn-Josephy, Hanni, Cuda, Carla M., Dominguez, Salina, Aprahamian, Tamar R., Watkins, Amanda A., Yasuda, Kei, Monach, Paul, Lafyatis, Robert, Rice, Lisa M., Haines, G. Kenneth, Gravallese, Ellen M., Baum, Rebecca, Richez, Christophe, Perlman, Harris, Bonegio, Ramon G., Rifkin, Ian R.

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Biomarkers in systemic sclerosis by Rice, Lisa M

“…Systemic sclerosis (SSc; scleroderma) is a chronic multisystem autoimmune disease that includes prominent skin involvement in all patients and is characterized…”
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