Search Results - "Rice, Audie G."

CS1, a Potential New Therapeutic Antibody Target for the Treatment of Multiple Myeloma by Hsi, Eric D, Steinle, Roxanne, Balasa, Balaji, Szmania, Susann, Draksharapu, Aparna, Shum, Benny P, Huseni, Mahrukh, Powers, David, Nanisetti, Amulya, Zhang, Yin, Rice, Audie G, van Abbema, Anne, Wong, Melanie, Liu, Gao, Zhan, Fenghuang, Dillon, Myles, Chen, Shihao, Rhodes, Susan, Fuh, Franklin, Tsurushita, Naoya, Kumar, Shankar, Vexler, Vladimir, Shaughnessy, Jr, John D, Barlogie, Bart, van Rhee, Frits, Hussein, Mohamad, Afar, Daniel E H, Williams, Marna B

“…Purpose: We generated a humanized antibody, HuLuc63, which specifically targets CS1 (CCND3 subset 1, CRACC, and SLAMF7), a cell surface glycoprotein not…”
Get full text

Combinatorial efficacy of anti-CS1 monoclonal antibody elotuzumab (HuLuc63) and bortezomib against multiple myeloma by van Rhee, Frits, Szmania, Susann M, Dillon, Myles, van Abbema, Anne M, Li, Xin, Stone, Mary K, Garg, Tarun K, Shi, JuMei, Moreno-Bost, Amberly M, Yun, Rui, Balasa, Balaji, Ganguly, Bishwa, Chao, Debra, Rice, Audie G, Zhan, Fenghuang, Shaughnessy, Jr, John D, Barlogie, Bart, Yaccoby, Shmuel, Afar, Daniel E H

“…Monoclonal antibody (mAb) therapy for multiple myeloma, a malignancy of plasma cells, has not been clinically efficacious in part due to a lack of appropriate…”
Get full text

Elotuzumab enhances natural killer cell activation and myeloma cell killing through interleukin-2 and TNF-α pathways by Balasa, Balaji, Yun, Rui, Belmar, Nicole A., Fox, Melvin, Chao, Debra T., Robbins, Michael D., Starling, Gary C., Rice, Audie G.

“…Elotuzumab is a humanized monoclonal antibody specific for signaling lymphocytic activation molecule-F7 (SLAMF7, also known as CS1, CD319, or CRACC) that…”
Get full text

Anti-CSl humanized monoclonal antibody HuLuc63 inhibits myeloma cell adhesion and induces antibody-dependent cellular cytotoxicity in the bone marrow milieu by TAI, Yu-Tzu, DILLON, Myles, VAN ABBEMA, Anne, JESAITIS, Lynne, CARAS, Ingrid, LAW, Debbie, WELLER, Edie, WANLING XIE, RICHARDSON, Paul, MUNSHI, Nikhil C, MATHIOT, Claire, AVET-LOISEAU, Hervé, WEIHUA SONG, AFAR, Daniel E. H, ANDERSON, Kenneth C, LEIBA, Merav, LI, Xian-Feng, BURGER, Peter, LEE, Alfred I, PODAR, Klaus, HIDESHIMA, Teru, RICE, Audie G

Get full text

Anti-CS1 humanized monoclonal antibody HuLuc63 inhibits myeloma cell adhesion and induces antibody-dependent cellular cytotoxicity in the bone marrow milieu by Tai, Yu-Tzu, Dillon, Myles, Song, Weihua, Leiba, Merav, Li, Xian-Feng, Burger, Peter, Lee, Alfred I., Podar, Klaus, Hideshima, Teru, Rice, Audie G., van Abbema, Anne, Jesaitis, Lynne, Caras, Ingrid, Law, Debbie, Weller, Edie, Xie, Wanling, Richardson, Paul, Munshi, Nikhil C., Mathiot, Claire, Avet-Loiseau, Hervé, Afar, Daniel E.H., Anderson, Kenneth C.

“…Currently, no approved monoclonal antibody (mAb) therapies exist for human multiple myeloma (MM). Here we characterized cell surface CS1 as a novel MM antigen…”
Get full text

SU9516: biochemical analysis of cdk inhibition and crystal structure in complex with cdk2 by Moshinsky, Deborah J, Bellamacina, Cornelia R, Boisvert, David C, Huang, Ping, Hui, Terence, Jancarik, Jaru, Kim, Sung-Hou, Rice, Audie G

“…SU9516 is a 3-substituted indolinone compound with demonstrated potent and selective inhibition toward cyclin dependent kinases (cdks). Here, we describe the…”
Get full text

Elotuzumab enhances natural killer cell activation and myeloma cell killing through interleukin-2 and TNF-[alpha] pathways by Balasa, Balaji, Yun, Rui, Belmar, Nicole A, Fox, Melvin, Chao, Debra T, Robbins, Michael D, Starling, Gary C, Rice, Audie G

“…Elotuzumab is a humanized monoclonal antibody specific for signaling lymphocytic activation molecule-F7 (SLAMF7, also known as CS1, CD319, or CRACC) that…”
Get full text

HuLuc63 in Combination Regimens with Conventional and Targeted Therapies Has Additive and Synergistic Anti-Tumor Activity in Pre-Clinical Models of Myeloma by Rice, Audie G., Dillon, Myles B.C., Van Abbema, Anne M., Afar, Daniel E.H.

“…Introduction: HuLuc63 is a humanized monoclonal antibody that targets CS1 (CD2 subset 1, CRACC, SLAMF7, CD319), a cell surface glycoprotein that is highly and…”
Get full text

Low Levels of Circulating CS1, a Newly Identified Multiple Myeloma (MM) Antigen for a Novel Humanized HuLuc63 Monoclonal Antibody, Is Detected in MM Patient Sera and Correlates with Active Disease by Tai, Yu-Tzu, Rice, Audie G., Leiba, Marav, Li, Xian-Feng, Burger, Peter, Song, Weihua, Prabhala, Rao, Dillon, Myles, Tolan, Edie, Xie, Xanling, Hideshima, Teru, Raje, Noopur, Richardson, Paul, Munshi, Nihkil C., Nagler, Arnon, Avet-Loiseau, Herve, Afar, Daniel E.H., Anderson, Kenneth C.

“…A new humanized anti-CS1 mAb HuLuc63 significantly induces antibody-dependent cellular cytotoxicity (ADCC) against autologous CS1-expressing patient MM cells…”
Get full text

The inhibitory complex of human α1-proteinase inhibitor and human leukocyte elastase is a neutrophil chemoattractant by BANDA, M. J, RICE, A. G, GRIFFIN, G. L, SENIOR, R. M

Get full text