Search Results - "Ricci, Roméo"
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NLRP3 phosphorylation in its LRR domain critically regulates inflammasome assembly
Published in Nature communications (06-10-2021)“…NLRP3 controls the secretion of inflammatory cytokines IL-1β/18 and pyroptosis by assembling the inflammasome. Upon coordinated priming and activation stimuli,…”
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2
Metabolic inflammation: connecting obesity and insulin resistance
Published in Annals of medicine (Helsinki) (01-05-2013)“…Insulin resistance is a pathological condition that arises when insulin signaling is impaired, forcing β-cells to produce more insulin in order to cope with…”
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3
Protein kinase D at the Golgi controls NLRP3 inflammasome activation
Published in The Journal of experimental medicine (04-09-2017)“…The inflammasomes are multiprotein complexes sensing tissue damage and infectious agents to initiate innate immune responses. Different inflammasomes…”
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4
Histone propionylation is a mark of active chromatin
Published in Nature structural & molecular biology (01-12-2017)“…Histone H3 lysine 14 is propionylated and butyrylated in vivo in a metabolic-state-dependent manner and these modifications promote high levels of…”
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5
Lysosomal degradation of newly formed insulin granules contributes to β cell failure in diabetes
Published in Nature communications (25-07-2019)“…Compromised function of insulin-secreting pancreatic β cells is central to the development and progression of Type 2 Diabetes (T2D). However, the mechanisms…”
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6
Arfaptine-1 controls secretory granule biogenesis
Published in M.S. Médecine sciences (01-03-2013)Get more information
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7
A PKD-MFF signaling axis couples mitochondrial fission to mitotic progression
Published in Cell reports (Cambridge) (18-05-2021)“…Mitochondria are highly dynamic organelles subjected to fission and fusion events. During mitosis, mitochondrial fission ensures equal distribution of…”
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Promoters of ASCL1‐ and NEUROD1‐dependent genes are specific targets of lurbinectedin in SCLC cells
Published in EMBO molecular medicine (07-04-2022)“…Small‐Cell Lung Cancer (SCLC) is an aggressive neuroendocrine malignancy with a poor prognosis. Here, we focus on the neuroendocrine SCLC subtypes, SCLC‐A and…”
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The BAR Domain Protein Arfaptin-1 Controls Secretory Granule Biogenesis at the trans-Golgi Network
Published in Developmental cell (16-10-2012)“…BAR domains can prevent membrane fission through their ability to shield necks of budding vesicles from fission-inducing factors. However, the physiological…”
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10
c-Jun/AP-1 controls liver regeneration by repressing p53/p21 and p38 MAPK activity
Published in Genes & development (15-08-2006)“…The AP-1 transcription factor c-Jun is a key regulator of hepatocyte proliferation. Mice lacking c-Jun in the liver (c-jun (Deltali*)) display impaired liver…”
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11
Regression of abdominal aortic aneurysm by inhibition of c-Jun N-terminal kinase
Published in Nature Medicine (01-12-2005)“…Abdominal aortic aneurysm (AAA) is a common disease among elderly people that, when surgical treatment is inapplicable, results in progressive expansion and…”
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A Cul3-Based E3 Ligase Removes Aurora B from Mitotic Chromosomes, Regulating Mitotic Progression and Completion of Cytokinesis in Human Cells
Published in Developmental cell (01-06-2007)“…Faithful cell-cycle progression is tightly controlled by the ubiquitin-proteasome system. Here we identify a human Cullin 3-based E3 ligase (Cul3) which is…”
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13
The AP-1 transcription factor c-Jun prevents stress-imposed maladaptive remodeling of the heart
Published in PloS one (10-09-2013)“…Systemic hypertension increases cardiac workload and subsequently induces signaling networks in heart that underlie myocyte growth (hypertrophic response)…”
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14
Stage-Specific Control of Neural Crest Stem Cell Proliferation by the Small Rho GTPases Cdc42 and Rac1
Published in Cell stem cell (06-03-2009)“…The neural crest (NC) generates a variety of neural and non-neural tissues during vertebrate development. Both migratory NC cells and their target structures…”
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15
Requirement of JNK2 for Scavenger Receptor A: Mediated Foam Cell Formation in Atherogenesis
Published in Science (American Association for the Advancement of Science) (26-11-2004)“…In vitro studies suggest a role for c-Jun N-terminal kinases (JNKs) in proatherogenic cellular processes. We show that atherosclerosis-prone ApoE-/-mice…”
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16
JunB can substitute for Jun in mouse development and cell proliferation
Published in Nature genetics (01-02-2002)“…The Jun and JunB components of the AP-1 transcription factor are known to have antagonistic functions. Here we show, by a knock-in strategy and a transgenic…”
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Molecular Imaging of Atherosclerotic Plaques Using a Human Antibody Against the Extra-Domain B of Fibronectin
Published in Circulation research (10-12-2004)“…Current imaging modalities of human atherosclerosis, such as angiography, ultrasound, and computed tomography, visualize plaque morphology. However, methods…”
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Loss of the anaphase-promoting complex in quiescent cells causes unscheduled hepatocyte proliferation
Published in Genes & development (01-01-2004)“…The anaphase-promoting complex or cyclosome (APC/C) is an ubiquitin protein ligase that together with Cdc20 and Cdh1 targets mitotic proteins for degradation…”
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Hijacking the NLRP3 inflammasome: a mechanism underlying viral respiratory disease?
Published in EMBO reports (03-07-2020)“…In contrast to highly specific sensor molecules of the innate immune system, the NLRP3 receptor detects a broad variety of danger signals including pathogens…”
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Hijacking the NLRP 3 inflammasome: a mechanism underlying viral respiratory disease?
Published in EMBO reports (03-07-2020)Get full text
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