Search Results - "Ribeiro de Sousa, Graziella"

The therapeutic potential of Aurora kinases targeting in glioblastoma: from preclinical research to translational oncology by de Almeida Magalhães, Taciani, de Sousa, Graziella Ribeiro, Alencastro Veiga Cruzeiro, Gustavo, Tone, Luiz Gonzaga, Valera, Elvis Terci, Borges, Kleiton Silva

“…Glioblastoma is the most common aggressive primary brain tumor. Standard care includes maximal safe surgical resection, radiation, and chemotherapy with…”
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Ultraconserved long non-coding RNA uc.112 is highly expressed in childhood T versus B-cell acute lymphoblastic leukemia by das Chagas, Pablo Ferreira, de Sousa, Graziella Ribeiro, Kodama, Márcio Hideki, de Biagi Junior, Carlos Alberto Oliveira, Yunes, José Andres, Brandalise, Silvia Regina, Calin, George Adrian, Tone, Luiz Gonzaga, Scrideli, Carlos Alberto, de Oliveira, Jaqueline Carvalho

“…Aberrant expression of long non-coding RNAs (lncRNAs) has been detected in several types of cancer, including acute lymphoblastic leukemia (ALL), but lncRNA…”
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A coordinated approach for the assessment of molecular subgroups in pediatric ependymomas using low-cost methods by de Sousa, Graziella Ribeiro, Lira, Régia Caroline Peixoto, de Almeida Magalhães, Taciani, da Silva, Keteryne Rodrigues, Nagano, Luis Fernando Peinado, Saggioro, Fabiano Pinto, Baroni, Mirella, Marie, Suely Kazue Nagahashi, Oba-Shinjo, Sueli Mieko, Brandelise, Silvia, de Paula Queiroz, Rosane Gomes, Brassesco, María Sol, Scrideli, Carlos Alberto, Tone, Luiz Gonzaga, Valera, Elvis Terci

“…Although ependymoma (EPN) molecular subgroups have been well established by integrated high-throughput platforms, low- and middle-income countries still need…”
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Significant increase of high-risk chromosome 1q gain and 6q loss at recurrence in posterior fossa group A ependymoma: A multicenter study by Donson, Andrew M, Bertrand, Kelsey C, Riemondy, Kent A, Gao, Dexiang, Zhuang, Yonghua, Sanford, Bridget, Norris, Gregory A, Chapman, Rebecca J, Fu, Rui, Willard, Nicholas, Griesinger, Andrea M, Ribeiro de Sousa, Graziella, Amani, Vladimir, Grimaldo, Enrique, Hankinson, Todd C, Booker, Ffyona, Sill, Martin, Grundy, Richard G, Pajtler, Kristian W, Ellison, David W, Foreman, Nicholas K, Ritzmann, Timothy A

“…Abstract Background Ependymoma (EPN) posterior fossa group A (PFA) has the highest rate of recurrence and the worst prognosis of all EPN molecular groups. At…”
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Activation of Hedgehog signaling by the oncogenic RELA fusion reveals a primary cilia-dependent vulnerability in supratentorial ependymoma by de Almeida Magalhães, Taciani, Alencastro Veiga Cruzeiro, Gustavo, Ribeiro de Sousa, Graziella, Englinger, Bernhard, Fernando Peinado Nagano, Luis, Ancliffe, Mathew, Rodrigues da Silva, Keteryne, Jiang, Li, Gojo, Johannes, Cherry Liu, Yulu, Carline, Brooke, Kuchibhotla, Mani, Pinto Saggioro, Fabiano, Kazue Nagahashi Marie, Suely, Mieko Oba-Shinjo, Sueli, Andres Yunes, José, Gomes de Paula Queiroz, Rosane, Alberto Scrideli, Carlos, Endersby, Raelene, Filbin, Mariella G, Silva Borges, Kleiton, Salic, Adrian, Gonzaga Tone, Luiz, Valera, Elvis Terci

“…Supratentorial RELA fusion (ST-RELA) ependymomas (EPNs) are resistant tumors without an approved chemotherapeutic treatment. Unfortunately, the molecular…”
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Notch pathway in ependymoma RELA-fused subgroup: upregulation and association with cancer stem cells markers expression by de Almeida Magalhães, Taciani, Cruzeiro, Gustavo Alencastro Veiga, de Sousa, Graziella Ribeiro, da Silva, Keteryne Rodrigues, Lira, Régia Caroline Peixoto, Scrideli, Carlos Alberto, Tone, Luiz Gonzaga, Valera, Elvis Terci, Borges, Kleiton Silva

“…RELA -fused supratentorial (ST) ependymoma (EPN) is an aggressive subgroup with poor prognosis. Considering the putative role of Notch signaling in the…”
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Identification of ITPR1 as a Hub Gene of Group 3 Medulloblastoma and Coregulated Genes with Potential Prognostic Values by das Chagas, Pablo Ferreira, de Sousa, Graziella Ribeiro, Veronez, Luciana Chain, Martins-da-Silva, Andrea, Corrêa, Carolina Alves Pereira, Cruzeiro, Gustavo Alencastro Veiga, Nagano, Luis Fernando Peinado, Queiroz, Rosane Gomes de Paula, Marie, Suely Kazue Nagahashi, Brandalise, Silvia Regina, Scrideli, Carlos Alberto, Tone, Luiz Gonzaga, Valera, Elvis Terci

“…The Group 3 Medulloblastoma (Grp3-MB) is an aggressive molecular subtype with a high incidence of metastasis and deaths. In this study, were used an RNA…”
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Integration of single-nuclei RNA-sequencing, spatial transcriptomics and histochemistry defines the complex microenvironment of NF1-associated plexiform neurofibromas by Amani, Vladimir, Riemondy, Kent A, Fu, Rui, Griesinger, Andrea M, Grimaldo, Enrique, De Sousa, Graziella Ribeiro, Gilani, Ahmed, Hemenway, Molly, Foreman, Nicholas K, Donson, Andrew M, Willard, Nicholas

“…Plexiform neurofibroma (PN) is a leading cause of morbidity in children with the genetic condition Neurofibromatosis Type 1 (NF1), often disfiguring or…”
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Musashi-1 regulates cell cycle and confers resistance to cisplatin treatment in Group 3/4 medulloblastomas cells by Chagas, Pablo Shimaoka, Veronez, Luciana Chain, de Sousa, Graziella Ribeiro, Cruzeiro, Gustavo Alencastro Veiga, Corrêa, Carolina Alves Pereira, Saggioro, Fabiano Pinto, de Paula Queiroz, Rosane Gomes, Marie, Suely Kazue Nagahashi, Brandalise, Silvia Regina, Cardinalli, Izilda Aparecida, Yunes, José Andres, Júnior, Carlos Gilberto Carlotti, Machado, Hélio Rubens, Santos, Marcelo Volpon, Scrideli, Carlos Alberto, Tone, Luiz Gonzaga, Valera, Elvis Terci

“…Groups (Grp) 3 and 4 are aggressive molecular subgroups of medulloblastoma (MB), with high rates of leptomeningeal dissemination. To date, there is still a…”
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The TP53 p.R337H mutation is uncommon in a Brazilian cohort of pediatric patients diagnosed with ependymoma by de Almeida Magalhães, Taciani, Borges, Kleiton Silva, de Sousa, Graziella Ribeiro, Brandalise, Silvia Regina, Seidinger, Ana Luiza, Scrideli, Carlos Alberto, Oba-Shinjo, Sueli Mieko, Yunes, José Andrés, Tone, Luiz Gonzaga

“…Background Ependymoma (EPN) is the third most common childhood cancer of the central nervous system. RELA fusion-positive EPN accounts for approximately 70% of…”
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YAP1 Is a Potential Predictive Molecular Biomarker for Response to SMO Inhibitor in Medulloblastoma Cells by Alencastro Veiga Cruzeiro, Gustavo, de Almeida Magalhães, Taciani, Ribeiro de Sousa, Graziella, Bonfim Silva, Ricardo, Alberto Oliveira de Biagi Junior, Carlos, Ferreira das Chagas, Pablo, Gomes de Paula Queiroz, Rosane, Alberto Scrideli, Carlos, Gonzaga Tone, Luiz, Terci Valera, Elvis

“…Advances in genomics have led to the identification of twelve relevant molecular subtypes within medulloblastoma (MB). The alpha subtype of Sonic…”
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Frequency of the TP53 p.R337H mutation in a Brazilian cohort of pediatric patients with solid tumors by Feitosa, José Antonio da Silva, das Chagas, Pablo Ferreira, de Sousa, Graziella Ribeiro, Queiroz, Rosane Gomes de Paula, Cruzeiro, Gustavo Alencastro Veiga, Tone, Luiz Gonzaga, Borges, Kleiton Silva, Valera, Elvis Terci

“…TP53 p.R337H germline mutation is highly prevalent in the Southern region of Brazil. We sought to investigate TP53 p.R337H mutation in pediatric tumor samples…”
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Should we keep rocking? Portraits from targeting Rho kinases in cancer by de Sousa, Graziella Ribeiro, Vieira, Gabriela Maciel, das Chagas, Pablo Ferreira, Pezuk, Julia Alejandra, Brassesco, María Sol

“…[Display omitted] •The Rho-associated coiled-coil kinases (ROCK1 and ROCK2) gained popularity and progressively been researched as anti-cancer targets.•Their…”
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SIGMAR1 Knockdown Enhances Oral Cancer Cell Chemosensitivity to Cisplatin via Decreased PD-L1 Expression by Chagas, Pablo Shimaoka, Garcia, Cristiana Bernadelli, Sousa, Lucas Oliveira, da Silva, Gabriel, Sousa, Graziella Ribeiro de, Marcelino, Rodolfo Cabral, de Matos, Leandro Luongo, Kowalski, Luiz Paulo, Salles, Évila, Wang, Lei, Baban, Babak, Leopoldino, Andréia Machado

“…Emerging evidence suggests that aberrant expression levels of Sigma1 (SIGMAR1, also known as sigma-1 receptor) have been implicated in the progression of…”
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Full-house nephropathy associated with high expression of SPATA5L1 due to a genetic pathogenic variant by de Carvalho, Luciana Martins, de Sousa, Graziella Ribeiro, Moura, Ronald, Saggioro, Fabiano, Facincani, Inalda, Costa, Roberto, Kahwage, Paola Pinheiro, Gomes de Paula Queiroz, Rosane, Valera, Elvis Terci, Crovella, Sergio, Sandrin-Garcia, Paula

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Abstract A22: YAP1 knockout in vitro models of medulloblastoma showed improved response to sonidegib by Cruzeiro, Gustavo Alencastro Veiga, de Almeida Magalhães, Taciani, de Sousa Ribeiro, Graziella, Ferreira das Chagas, Pablo, Silva, Ricardo Bonfim, Chatterje, Sampurna, Scrideli, Carlos Alberto, Tone, Luiz Gonzaga

“…Background: Medulloblastoma (MB) is the most common malignant brain tumor in childhood. Despite improvement in current treatment, children still suffer from…”
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Evaluating H3F3A K27M and G34R/V somatic mutations in a cohort of pediatric brain tumors of different and rare histologies by Oliveira, Vinicius Fernandes, De Sousa, Graziella Ribeiro, dos Santos, Antonio Carlos, Saggioro, Fabiano Pinto, Machado, Helio Rubens, de Oliveira, Ricardo Santos, Tone, Luiz Gonzaga, Valera, Elvis Terci

“…Purpose Somatic mutations on H3 histone are currently considered a genetic hallmark for midline pediatric high-grade gliomas (HGGs). Yet, different tumor…”
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Perillyl alcohol for pediatric TP53- and RAS-mutated SHH-medulloblastoma: an in vitro and in vivo translational pre-clinical study by Silva, Marcela de Oliveira, de Sousa, Graziella Ribeiro, Simões, Sarah Capelupe, Nicolucci, Patrícia, Tamashiro, Edwin, Saggioro, Fabiano, de Oliveira, Ricardo Santos, Brassesco, María Sol

“…Purpose Inhalation of perillyl alcohol (POH) recently emerged as an investigational promising antiglioma strategy. However, little attention has been paid to…”
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A novel type of C11orf95-LOC-RELA fusion in a grade II supratentorial ependymoma: report of a case with literature review by de Sousa, Graziella Ribeiro, Marie, Suely Kazue Nagahashi, Oba-Shinjo, Sueli Mieko, Ramalho, Leandra Náira Zambelli, Tone, Luiz Gonzaga, Valera, Elvis Terci

“…Background Ependymoma (EPN) is the third most common central nervous system tumor in childhood. Recent advances in the molecular classification of EPN revealed…”
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Abstract 1034: SIGMAR1 as a novel potential prognostic biomarker that regulates PD-L1 expression in oral cancer by Chagas, Pablo Shimaoka, da Silva, Gabriel, de Sousa, Graziella Ribeiro, Garcia, Cristiana Bernadelli, Sousa, Lucas Oliveira, Marcelino, Rodolfo Cabral, da Silva Souza, Raphael Luiz Lobo, de Matos, Leandro Luongo, Kowalski, Luiz Paulo, da Silva Lopes Salles, Évila, Wang, Lei P., Baban, Babak, Leopoldino, Andreia Machado

“…Background: The SIGMAR1 receptor is a regulator of immunity and inflammation. Together, these key processes can support or restrain cancer progression and…”
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