Search Results - "Ribeiro da Cunha, Bernardo"

Antibiotic Discovery: Where Have We Come from, Where Do We Go? by Ribeiro da Cunha, Bernardo, Fonseca, Luís P, Calado, Cecília R C

“…Given the increase in antibiotic-resistant bacteria, alongside the alarmingly low rate of newly approved antibiotics for clinical usage, we are on the verge of…”
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Metabolic Fingerprinting with Fourier-Transform Infrared (FTIR) Spectroscopy: Towards a High-Throughput Screening Assay for Antibiotic Discovery and Mechanism-of-Action Elucidation by Ribeiro da Cunha, Bernardo, Fonseca, Luís P, Calado, Cecília R C

“…The discovery of antibiotics has been slowing to a halt. Phenotypic screening is once again at the forefront of antibiotic discovery, yet Mechanism-Of-Action…”
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Infection biomarkers based on metabolomics by Araújo, Rúben Alexandre Dinis, Bento, Luís, Henrique Fonseca, Tiago Alexandre, Von Rekowski, Cristiana, Ribeiro da Cunha, Bernardo, Calado, Cecília

“…Este trabalho foi financiado pelo Concurso Anual para Projetos de Investigação, Desenvolvimento, Inovação e Criação Artística (IDI&CA) 2020 do Instituto…”
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Technologies for High-Throughput Identification of Antibiotic Mechanism of Action by da Cunha, Bernardo Ribeiro, Zoio, Paulo, Fonseca, Luís P., Calado, Cecília R. C.

“…There are two main strategies for antibiotic discovery: target-based and phenotypic screening. The latter has been much more successful in delivering…”
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Simultaneous elucidation of antibiotic mechanism of action and potency with high-throughput Fourier-transform infrared (FTIR) spectroscopy and machine learning by Ribeiro da Cunha, Bernardo, P. Fonseca, Luis, Calado, Cecília

“…Este trabalho foi financiado pelo Concurso Anual para Projetos de Investigação, Desenvolvimento, Inovação e Criação Artística (IDI&CA) 2017 do Instituto…”
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Fast identification of off-target liabilities in early antibiotic discovery with Fourier-transform infrared spectroscopy by Ribeiro da Cunha, Bernardo, Aleixo, Sandra, P. Fonseca, Luis, Calado, Cecília

“…Este trabalho foi financiado pelo Concurso Anual para Projetos de Investigação, Desenvolvimento, Inovação e Criação Artística (IDI&CA) 2018 do Instituto…”
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Simultaneous elucidation of antibiotic mechanism of action and potency with high-throughput Fourier-transform infrared by Ribeiro da Cunha, Bernardo, Fonseca, Luís P, Calado, Cecília R. C

“…The low rate of discovery and rapid spread of resistant pathogens have made antibiotic discovery a worldwide priority. In cell-based screening, the mechanism…”
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A phenotypic screening bioassay for Escherichia coli stress and antibiotic responses based on Fourier‐transform infrared (FTIR) spectroscopy and multivariate analysis by Ribeiro da Cunha, B., Fonseca, L.P., Calado, C.R.C.

“…Aims To develop and optimize a Fourier‐transform infrared spectroscopy (FTIRS) phenotypic screening bioassay for stress responses, regarding the effect of…”
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Metabolic profiling of recombinant Escherichia coli cultivations based on high‐throughput FT‐MIR spectroscopic analysis by Sales, Kevin C., Rosa, Filipa, Cunha, Bernardo R., Sampaio, Pedro N., Lopes, Marta B., Calado, Cecília R. C.

“…Escherichia coli is one of the most used host microorganism for the production of recombinant products, such as heterologous proteins and plasmids. However,…”
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Emoldurar a Paisagem: Desenhar Um Jardim Para Sines by da Cunha Ribeiro, João Bernardo

“…A presente investigação desta dissertação de mestrado integrado em arquitectura consiste numa revisão e consequente reflexão crítica do trabalho desenvolvido…”
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Towards an automated statistical workflow for biomarker screening in Fourier-transform infrared spectroscopy by Cunha, Bernardo R., Aleixo, Sandra M., Fonseca, Luis P., Calado, Cecilia C.

“…The increasing availability and sensitivity of analytical technologies has resulted in much higher complexity of molecular and cellular data, which biomarkers…”
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Optimization of a bioassay to evaluate Escherichia coli stress responses by Cunha, Bernardo, Russo, Ana, Fonseca, Luis, Calado, Cecilia

“…During the genomics era, great emphasis was placed on sequencing microbial genomes and understanding their global gene expression. Later in the post-genomic…”
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High-throughput bioassay for mechanism of action determination of antibacterial drugs by Cunha, Bernardo, Fonseca, Luis, Calado, Cecilia

“…While the `war' on infectious diseases has been considered won, antibiotic-resistant bacteria are currently responsible for 25,000 death's yearly in Europe. No…”
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Biopharmaceuticals process monitoring based on infrared spectroscopy according to Quality by Design by Sales, Kevin, Cunha, Bernardo R., Calado, Cecilia R. C.

“…Escherichia coli, the most common host microorganism to produce high value biopharmaceuticals, presents, however a natural variability due to high sensitivity…”
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Development of a high-throughput monitoring technique of bacteria photodynamic inactivation by Cunha, Bernardo, Sampaio, Pedro N., Calado, Cecilia R. C.

“…Bacterial infections and the fight against them have been one of the major concerns of mankind since the dawn of time. During the 'golden years' of antibiotic…”
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Mid-infrared spectroscopy: A groundbreaking tool for monitoring mammalian cells processes by Rosa, Filipa O. P., Cunha, Bernardo, Carmelo, Joana G., Fernandes-Platzgummer, Ana, da Silva, Claudia L., Calado, Cecilia R. C.

“…Mammalian cells are extensively used in cell biology studies, e.g. as a model system of human pathologies, or as a major source of very high-value…”
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Molecular fingerprint of human gastric cell line infected by Helicobacter pylori by Sampaio, Pedro N., Cunha, Bernardo, Rosa, Filipa, Sales, Kevin, Lopes, Marta, Calado, Cecilia R. C.

“…Helicobacter pylori infection represents a serious health problem, given its association with serious gastric diseases as gastric ulcers, cancer and MALT…”
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