Search Results - "Ribeiro Chagas, Jair"
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Human plasma kallikrein: roles in coagulation, fibrinolysis, inflammation pathways, and beyond
Published in Frontiers in physiology (30-08-2023)“…Human plasma kallikrein (PKa) is obtained by activating its precursor, prekallikrein (PK), historically named the Fletcher factor. Human PKa and tissue…”
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Enzymatic profiling of human kallikrein 14 using phage-display substrate technology
Published in Biological chemistry (01-03-2005)“…The human KLK14 gene is one of the newly identified serine protease genes belonging to the human kallikrein family, which contains 15 members. KLK14 , like all…”
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Validation of housekeeping genes in the brains of rats submitted to chronic intermittent hypoxia, a sleep apnea model
Published in PloS one (07-10-2014)“…Obstructive sleep apnea (OSA) is a syndrome characterized by intermittent nocturnal hypoxia, sleep fragmentation, hypercapnia and respiratory effort, and it…”
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Atlantic Forest's and Caatinga's semiarid soils and their potential as a source for halothermotolerant actinomycetes and proteolytic enzymes
Published in Environmental technology (12-05-2023)“…Actinomycetes are versatile about their metabolism, displaying high capacity to produce bioactive metabolites. Enzymes from actinomycetes represent new…”
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The Blood-Brain Barrier Breakdown During Acute Phase of the Pilocarpine Model of Epilepsy Is Dynamic and Time-Dependent
Published in Frontiers in neurology (16-04-2019)“…The maintenance of blood-brain barrier (BBB) integrity is essential for providing a suitable environment for nervous tissue function. BBB disruption is…”
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Interactions between carboxypeptidase M and kinin B1 receptor in endothelial cells
Published in Inflammation research (01-10-2019)“…Introduction Carboxypeptidase M (CPM) is a glycosylphosphatidylinositol anchored enzyme that plays an important role in the kallikrein–kinin system (KKS). CPM…”
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Late effects of sleep restriction: Potentiating weight gain and insulin resistance arising from a high‐fat diet in mice
Published in Obesity (Silver Spring, Md.) (01-02-2015)“…Objective Epidemiological studies show the association of sleep restriction (SR) with obesity and insulin resistance. Experimental studies are limited to the…”
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Considerations over a Case of Suspected Therapeutic Failure in Pediatric Patients after Switching Valproate Manufacturers
Published in Innovations in pharmacy (28-08-2020)“…: Product switching followed by suspected adverse events are common and unsettling for antiepileptic drugs. The objective of this case study was to describe…”
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Analysis of the stability of housekeeping gene expression in the left cardiac ventricle of rats submitted to chronic intermittent hypoxia
Published in Jornal brasileiro de pneumologia (01-05-2016)“…Obstructive sleep apnea (OSA) has been associated with oxidative stress and various cardiovascular consequences, such as increased cardiovascular disease risk…”
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Corrigendum: The Blood-Brain Barrier Breakdown During Acute Phase of the Pilocarpine Model of Epilepsy Is Dynamic and Time-Dependent
Published in Frontiers in neurology (10-06-2019)“…[This corrects the article DOI: 10.3389/fneur.2019.00382.]…”
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Chronic intermittent hypoxia increases encoding pigment epithelium-derived factor gene expression, although not that of the protein itself, in the temporal cortex of rats
Published in Jornal brasileiro de pneumologia (01-01-2015)“…Obstructive sleep apnea syndrome is mainly characterized by intermittent hypoxia (IH) during sleep, being associated with several complications. Exposure to IH…”
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Activity of peptidases in the central nervous system in experimental models of deprivation of sleep
Published in Annals of general psychiatry (17-04-2008)Get full text
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Substrate specificity of human kallikrein 2 (hK2) as determined by phage display technology
Published in European journal of biochemistry (01-06-2002)“…Human glandular kallikrein 2 (hK2) is a trypsin‐like serine protease expressed predominantly in the prostate epithelium. Recently, hK2 has proven to be a…”
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Hydrolysis by Cathepsin B of Fluorescent Peptides Derived From Human Prorenin
Published in Hypertension (Dallas, Tex. 1979) (01-06-2000)“…Cathepsin B is a lysosomal thiolprotease that, because of its colocalization with renin and its ability to activate prorenin, has been proposed as a prorenin…”
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Unmet Quality Needs in Oral Drug Delivery: Contrasts of Drug Content and Uniformity on Distinct Approaches for Achieving Individual Dosing
Published in AAPS PharmSciTech (08-11-2019)“…Individualized dosing is often required in pharmacotherapy, particularly for pediatric and geriatric patients and adjustment of drugs that demand dose…”
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Plasma ACE activity after aerobic exercise training is related to sleep in migraine patients: A secondary, per protocol analysis
Published in Revista Headache Medicine (Online) (31-03-2020)“…Angiotensin converting enzyme-1 (ACE) has been implicated in sleep regulation and nociception. In a secondary, per-protocol analysis, we investigated the…”
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Evaluation of Home Polysomnography Findings, Quality of Sleep, and Fatigue in Inflammatory Bowel Disease: A Case Series
Published in Journal of clinical sleep medicine (15-01-2019)“…The pathogenesis of inflammatory bowel disease (IBD) is not well understood, and sleep disorders may be potential triggers for IBD. Thus, an evaluation of the…”
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Expression and activity of thimet oligopeptidase (TOP) are modified in the hippocampus of subjects with temporal lobe epilepsy (TLE)
Published in Epilepsia (Copenhagen) (01-05-2014)“…Summary Objective Thimet oligopeptidase (TOP) is a metalloprotease that has been associated with peptide processing in several nervous system structures, and…”
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