Search Results - "Ribeiro, Jose M.C."
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Genomics of Loa loa, a Wolbachia-free filarial parasite of humans
Published in Nature genetics (01-05-2013)“…Thomas Nutman and colleagues report the draft genome of the filarial pathogen Loa loa , the African eyeworm. They also report coverage of two other filarial…”
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A comparison of Illumina and PacBio methods to build tick salivary gland transcriptomes confirms large expression of lipocalins and other salivary protein families that are not represented in available tick genomes
Published in Ticks and tick-borne diseases (01-11-2023)“…Tick saliva helps blood feeding by its antihemostatic and immunomodulatory activities. Tick salivary gland transcriptomes (sialotranscriptomes) revealed…”
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Functional and structural similarities of D7 proteins in the independently-evolved salivary secretions of sand flies and mosquitoes
Published in Scientific reports (29-03-2019)“…The habit of blood feeding evolved independently in many insect orders of families. Sand flies and mosquitoes belong to separate lineages of blood-feeding…”
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Ixonnexin from Tick Saliva Promotes Fibrinolysis by Interacting with Plasminogen and Tissue-Type Plasminogen Activator, and Prevents Arterial Thrombosis
Published in Scientific reports (19-03-2018)“…Tick saliva is a rich source of modulators of vascular biology. We have characterized Ixonnexin, a member of the “Basic-tail” family of salivary proteins from…”
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Identification and characterization of seminal fluid proteins in the Asian tiger mosquito, Aedes albopictus
Published in PLoS neglected tropical diseases (01-06-2014)“…The Asian tiger mosquito (Aedes albopictus) is an important vector for pathogens that affect human health, including the viruses that cause dengue and…”
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Structure, Function, and Evolution of Biogenic Amine-binding Proteins in Soft Ticks
Published in The Journal of biological chemistry (04-07-2008)“…Two highly abundant lipocalins, monomine and monotonin, have been isolated from the salivary gland of the soft tick Argas monolakensis and shown to bind…”
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In Vitro Mode of Action and Anti-thrombotic Activity of Boophilin, a Multifunctional Kunitz Protease Inhibitor from the Midgut of a Tick Vector of Babesiosis, Rhipicephalus microplus
Published in PLoS neglected tropical diseases (01-01-2016)“…Hematophagous mosquitos and ticks avoid host hemostatic system through expression of enzyme inhibitors targeting proteolytic reactions of the coagulation and…”
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Function, mechanism and evolution of the moubatin-clade of soft tick lipocalins
Published in Insect biochemistry and molecular biology (01-09-2008)“…The “moubatin-clade” of soft tick lipocalins, although monophyletic, shows clear signs of paralogy as indicated by the various functions associated with this…”
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Antiinflammatory and Immunosuppressive Activity of Sialostatin L, a Salivary Cystatin from the Tick Ixodes scapularis
Published in The Journal of biological chemistry (08-09-2006)“…Here we report the ability of the tick Ixodes scapularis, the main vector of Lyme disease in the United States, to actively and specifically affect the host…”
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Cutinase-like proteins of Mycobacterium tuberculosis: characterization of their variable enzymatic functions and active site identification
Published in The FASEB journal (01-06-2009)“…Discovery and characterization of novel secreted enzymes of Mycobacterium tuberculosis are important for understanding the pathogenesis of one of the most…”
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Purification and characterization of a novel salivary antimicrobial peptide from the tick, Ixodes scapularis
Published in Biochemical and biophysical research communications (18-12-2009)“…A novel antimicrobial peptide was isolated from the saliva of the Lyme disease tick vector, Ixodes scapularis, henceforth designated as ISAMP ( I. scapularis…”
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Novel Family of Insect Salivary Inhibitors Blocks Contact Pathway Activation by Binding to Polyphosphate, Heparin, and Dextran Sulfate
Published in Arteriosclerosis, thrombosis, and vascular biology (01-12-2013)“…OBJECTIVE—Polyphosphate and heparin are anionic polymers released by activated mast cells and platelets that are known to stimulate the contact pathway of…”
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Selective Cysteine Protease Inhibition Contributes to Blood-feeding Success of the Tick Ixodes scapularis
Published in The Journal of biological chemistry (05-10-2007)“…Ixodes scapularis is the main vector of Lyme disease in the eastern and central United States. Tick salivary secretion has been shown as important for both…”
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The structures of two salivary proteins from the West Nile vector Culex quinquefasciatus reveal a beta-trefoil fold with putative sugar binding properties
Published in Current research in structural biology (01-01-2021)“…Female mosquitoes require blood meals for egg development. The saliva of blood feeding arthropods contains biochemically active molecules, whose…”
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Molecular Evolution of Immune Genes in the Malaria Mosquito Anopheles gambiae
Published in PloS one (23-02-2009)“…Background: As pathogens that circumvent the host immune response are favoured by selection, so are host alleles that reduce parasite load. Such evolutionary…”
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The Anopheles gambiae salivary protein gSG6: An anopheline-specific protein with a blood-feeding role
Published in Insect biochemistry and molecular biology (01-07-2009)“…The Anopheles gambiae salivary gland protein 6 (gSG6) is a small protein specifically found in the salivary glands of adult female mosquitoes. We report here…”
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Simplagrin, a platelet aggregation inhibitor from Simulium nigrimanum salivary glands specifically binds to the Von Willebrand factor receptor in collagen and inhibits carotid thrombus formation in vivo
Published in PLoS neglected tropical diseases (01-06-2014)“…Among the several challenges faced by bloodsucking arthropods, the vertebrate hemostatic response against blood loss represents an important barrier to…”
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Structure and Dynamics of Male Swarms of Anopheles gambiae
Published in Journal of medical entomology (01-03-2009)“…Mosquito swarms are poorly understood mating aggregations. In the malaria vector Anopheles gambiae Giles, they are known to depend on environmental conditions,…”
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Immunological diversity within a family of cutinase-like proteins of Mycobacterium tuberculosis
Published in Vaccine (23-07-2008)“…Abstract Secreted proteins of Mycobacterium tuberculosis play key roles in the assembly of the mycobacterial cell wall, with many being major targets of the…”
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Microarray-based analysis of differential gene expression between infective and noninfective larvae of Strongyloides stercoralis
Published in PLoS neglected tropical diseases (01-05-2011)“…Differences between noninfective first-stage (L1) and infective third-stage (L3i) larvae of parasitic nematode Strongyloides stercoralis at the molecular level…”
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