Search Results - "Ribeiro, D.L."
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Cytotoxic, genotoxic, and oxidative stress-inducing effect of an l-amino acid oxidase isolated from Bothrops jararacussu venom in a co-culture model of HepG2 and HUVEC cells
Published in International journal of biological macromolecules (15-04-2019)“…Hepatocellular carcinoma incidence rates have increased worldwide, which encouraged the development of new chemotherapeutic drugs. l-Amino acid oxidases from…”
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The toxin BjussuLAAO-II induces oxidative stress and DNA damage, upregulates the inflammatory cytokine genes TNF and IL6, and downregulates the apoptotic-related genes BAX, BCL2 and RELA in human Caco-2 cells
Published in International journal of biological macromolecules (01-04-2018)“…•BjussuLAAO-II is a snake venom toxin with cytotoxic effects towards Caco-2 cells.•The toxin induces necrosis, apoptosis, oxidative stress, and DNA damage.•The…”
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Protective effects of the exopolysaccharide Lasiodiplodan against DNA damage and inflammation induced by doxorubicin in rats: Cytogenetic and gene expression assays
Published in Toxicology (Amsterdam) (01-02-2017)“…Abstract The lasiodiplodan (LS) is a β-(1 → 6)- d -glucan produced by the fungus Lasiodiplodia theobromae and some of the biological activities of LS were…”
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Cytotoxic and Antiproliferative Effects of ‘Brachydin C' in DU-145 Cells Grown in 3D Multicellular Tumor Spheroids
Published in Toxicology letters (01-09-2021)Get full text
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Evaluation of DNA damage and modulation of gene expression in the heart of rats that received vitamin D3 supplemented or deficient diets
Published in Toxicology letters (10-10-2018)Get full text
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Randomized, double-blind, sham-controlled trial to evaluate the efficacy and tolerability of electroconvulsive therapy in patients with clozapine-resistant schizophrenia
Published in Schizophrenia research (01-06-2024)“…There is no established treatment for patients with clozapine-resistant schizophrenia (CRS). Clozapine augmentation strategies with antipsychotics or others…”
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Cytotoxicity and genotoxicity of chlorogenic acid alone or associated with the demethylating drug 5-azacytidine in Jurkat cells
Published in Toxicology letters (16-09-2016)Get full text
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Cytotoxic and genotoxic effects of high concentrations of the immunosuppressive drugs cyclosporine and tacrolimus in MRC-5 cells
Published in Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie (01-02-2015)“…Immunosuppressive drugs are used to suppress immune system activity in transplant patients and reduce the risk of organ rejection. The present study evaluated…”
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adaptive compensations in endocrine pancreas from glucocorticoid-treated rats are reversible after the interruption of treatment
Published in Acta Physiologica (01-11-2010)“…Glucocorticoid administration induces insulin resistance (IR) and enhances islet mass and insulin secretion in rodents and humans. Here, we analysed whether…”
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Effects of maternal diabetes on male offspring: high cell proliferation and increased activity of MMP-2 in the ventral prostate
Published in Cell and tissue research (01-10-2014)“…This study presents a comprehensive view of the histological and functional status of the prostate of adult rat offspring of mothers subjected to gestational…”
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Quality of domestic cat semen collected by urethral catheterization after the use of different alpha 2-adrenergic agonists
Published in Journal of feline medicine and surgery (01-08-2021)“…Objectives We compared the effects of two alpha (α)2-adrenergic agonists on semen traits. Methods In this study, 13 adult domestic cats were divided into two…”
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