The Newcastle Pediatric Mitochondrial Disease Scale: translation and cultural adaptation for use in Brazil

The aim of this study was to translate and adapt the Newcastle Paediatric Mitochondrial Disease Scale (NPMDS) to Portuguese for use in Brazil. The scale was applied in 20 pediatric patients with mitochondrial disease, in three groups: myopathy (n = 4); Leigh syndrome (n = 8); and encephalomyopathy (...

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Bibliographic Details
Published in:	Arquivos de neuro-psiquiatria Vol. 74; no. 11; pp. 909 - 913
Main Authors:	Campolina-Sampaio, Gabriela Palhares, Lasmar, Laura Maria de Lima Belizário Facury, Ribeiro, Beatriz Silva Vilela, Giannetti, Juliana Gurgel
Format:	Journal Article
Language:	English
Published:	Brazil Academia Brasileira de Neurologia - ABNEURO 01-11-2016 Academia Brasileira de Neurologia (ABNEURO)
Subjects:	Adolescent Brazil Child Child, Preschool Cross-Cultural Comparison Cross-Sectional Studies Disease Progression Female Humans Language Leigh disease Leigh Disease - physiopathology Male Mitochondrial Diseases - physiopathology mitochondrial diseases, mitochondrial myopathies mitochondrial encephalomyopathies Mitochondrial Encephalomyopathies - physiopathology Mitochondrial Myopathies - physiopathology NEUROSCIENCES Newcastle disease PSYCHIATRY Reproducibility of Results Surveys and Questionnaires Translations Brazil mitochondrial diseases, mitochondrial myopathies Newcastle disease doença de Newcastle mitochondrial encephalomyopathies Leigh disease miopatias mitocondriais encefalomiopatias mitocondriais doenças mitocondriais doença de Leigh
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Summary:	The aim of this study was to translate and adapt the Newcastle Paediatric Mitochondrial Disease Scale (NPMDS) to Portuguese for use in Brazil. The scale was applied in 20 pediatric patients with mitochondrial disease, in three groups: myopathy (n = 4); Leigh syndrome (n = 8); and encephalomyopathy (n = 8). Scores were obtained for the various dimensions of the NPMDS, and comparisons were drawn between the groups. There was a statistically significant difference between the myopathy group and the Leigh syndrome group (p = 0.0085), as well as between the myopathy and encephalomyopathy groups (p = 0.01). The translation of the NPMDS, and its adaptation to the socioeconomic and cultural conditions in Brazil, make the NPMDS score useful as an additional parameter in the evaluation and monitoring of pediatric patients with MD in Brazil.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Undefined-1 ObjectType-Feature-3 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0004-282X 1678-4227 1678-4227 0004-282X
DOI:	10.1590/0004-282X20160137