Search Results - "Ribó, Sílvia"
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In Utero Undernutrition in Male Mice Programs Liver Lipid Metabolism in the Second-Generation Offspring Involving Altered Lxra DNA Methylation
Published in Cell metabolism (03-06-2014)“…Obesity and type 2 diabetes have a heritable component that is not attributable to genetic factors. Instead, epigenetic mechanisms may play a role. We have…”
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Dietary Betaine Supplementation Increases Fgf21 Levels to Improve Glucose Homeostasis and Reduce Hepatic Lipid Accumulation in Mice
Published in Diabetes (New York, N.Y.) (01-04-2016)“…Identifying markers of human insulin resistance may permit development of new approaches for treatment and prevention of type 2 diabetes. To this end, we…”
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3
Intergenerational Inheritance of Hepatic Steatosis in a Mouse Model of Childhood Obesity: Potential Involvement of Germ-Line microRNAs
Published in Nutrients (01-03-2023)“…Childhood obesity increases the risk of developing metabolic syndrome later in life. Moreover, metabolic dysfunction may be inherited into the following…”
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4
The role of nutrition on epigenetic modifications and their implications on health
Published in Biochimie (01-11-2012)“…Nutrition plays a key role in many aspects of health and dietary imbalances are major determinants of chronic diseases including cardiovascular disease,…”
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5
Quantitative analysis of protein lipidation and acyl-CoAs reveals substrate preferences of the S -acylation machinery
Published in Chemical science (Cambridge) (14-08-2024)“…Protein palmitoylation or -acylation has emerged as a key regulator of cellular processes. Increasing evidence shows that this modification is not restricted…”
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Neonatal overfeeding during lactation rapidly and permanently misaligns the hepatic circadian rhythm and programmes adult NAFLD
Published in Molecular metabolism (Germany) (01-03-2021)“…Childhood obesity is a strong risk factor for adult obesity, type 2 diabetes, and cardiovascular disease. The mechanisms that link early adiposity with…”
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7
Increasing breast milk betaine modulates Akkermansia abundance in mammalian neonates and improves long-term metabolic health
Published in Science translational medicine (31-03-2021)“…Accelerated postnatal growth is a potentially modifiable risk factor for future obesity. To study how specific breast milk components contribute to early…”
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8
Dietary betaine supplementation increases Fgf21 levels to improve glucose homeostasis and reduce hepatic lipid accumulation in mice
Published in Diabetes (New York, N.Y.) (01-04-2016)“…Identifying markers of human insulin resistance may permit development of new approaches for treatment and prevention of type 2 diabetes. To this end, we…”
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9
GSDMD drives canonical inflammasome‐induced neutrophil pyroptosis and is dispensable for NETosis
Published in EMBO reports (06-10-2022)“…Neutrophils are the most prevalent immune cells in circulation, but the repertoire of canonical inflammasomes in neutrophils and their respective involvement…”
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10
Nlrp3 inflammasome activation in macrophages suffices for inducing autoinflammation in mice
Published in EMBO reports (05-07-2022)“…Cryopyrin‐associated periodic syndromes (CAPS) are a spectrum of autoinflammatory disorders caused by gain‐of‐function NLRP3 mutant proteins that form…”
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Transgenerational epigenetic inheritance of diabetes risk as a consequence of early nutritional imbalances
Published in Proceedings of the Nutrition Society (01-02-2016)“…In today's world, there is an unprecedented rise in the prevalence of chronic metabolic diseases, including obesity, insulin resistance and type 2 diabetes…”
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12
Epigenetic programming at the Mogat1 locus may link neonatal overnutrition with long‐term hepatic steatosis and insulin resistance
Published in The FASEB journal (01-11-2018)“…ABSTRACT Postnatal overfeeding increases the risk of chronic diseases later in life, including obesity, insulin resistance, hepatic steatosis, and type 2…”
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