Search Results - "Rhys, Guto G"

Structural resolution of switchable states of a de novo peptide assembly by Dawson, William M., Lang, Eric J. M., Rhys, Guto G., Shelley, Kathryn L., Williams, Christopher, Brady, R. Leo, Crump, Matthew P., Mulholland, Adrian J., Woolfson, Derek N.

“…De novo protein design is advancing rapidly. However, most designs are for single states. Here we report a de novo designed peptide that forms multiple…”
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Maintaining and breaking symmetry in homomeric coiled-coil assemblies by Rhys, Guto G., Wood, Christopher W., Lang, Eric J. M., Mulholland, Adrian J., Brady, R. Leo, Thomson, Andrew R., Woolfson, Derek N.

“…In coiled-coil (CC) protein structures α-helices wrap around one another to form rope-like assemblies. Most natural and designed CCs have two–four helices and…”
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Differential sensing with arrays of de novo designed peptide assemblies by Dawson, William M., Shelley, Kathryn L., Fletcher, Jordan M., Scott, D. Arne, Lombardi, Lucia, Rhys, Guto G., LaGambina, Tania J., Obst, Ulrike, Burton, Antony J., Cross, Jessica A., Davies, George, Martin, Freddie J. O., Wiseman, Francis J., Brady, R. Leo, Tew, David, Wood, Christopher W., Woolfson, Derek N.

“…Differential sensing attempts to mimic the mammalian senses of smell and taste to identify analytes and complex mixtures. In place of hundreds of complex,…”
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Bioinspired Silicification Reveals Structural Detail in Self-Assembled Peptide Cages by Galloway, Johanna M, Senior, Laura, Fletcher, Jordan M, Beesley, Joseph L, Hodgson, Lorna R, Harniman, Robert L, Mantell, Judith M, Coombs, Jennifer, Rhys, Guto G, Xue, Wei-Feng, Mosayebi, Majid, Linden, Noah, Liverpool, Tanniemola B, Curnow, Paul, Verkade, Paul, Woolfson, Derek N

“…Understanding how molecules in self-assembled soft-matter nanostructures are organized is essential for improving the design of next-generation nanomaterials…”
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Towards functional de novo designed proteins by Dawson, William M, Rhys, Guto G, Woolfson, Derek N

“…[Display omitted] Our ability to design completely de novo proteins is improving rapidly. This is true of all three main approaches to de novo protein design,…”
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Coiled coils 9-to-5: rational de novo design of α-helical barrels with tunable oligomeric states by Dawson, William M, Martin, Freddie J O, Rhys, Guto G, Shelley, Kathryn L, Brady, R Leo, Woolfson, Derek N

“…The rational design of linear peptides that assemble controllably and predictably in water is challenging. Short sequences must encode unique target structures…”
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De novo designed peptides for cellular delivery and subcellular localisation by Rhys, Guto G., Cross, Jessica A., Dawson, William M., Thompson, Harry F., Shanmugaratnam, Sooruban, Savery, Nigel J., Dodding, Mark P., Höcker, Birte, Woolfson, Derek N.

“…Increasingly, it is possible to design peptide and protein assemblies de novo from first principles or computationally. This approach provides new routes to…”
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Navigating the Structural Landscape of De Novo α‑Helical Bundles by Rhys, Guto G, Wood, Christopher W, Beesley, Joseph L, Zaccai, Nathan R, Burton, Antony J, Brady, R. Leo, Thomson, Andrew R, Woolfson, Derek N

“…The association of amphipathic α helices in water leads to α-helical-bundle protein structures. However, the driving force for thisthe hydrophobic effectis…”
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De novo coiled-coil peptides as scaffolds for disrupting protein-protein interactions by Fletcher, Jordan M, Horner, Katherine A, Bartlett, Gail J, Rhys, Guto G, Wilson, Andrew J, Woolfson, Derek N

“…Protein-protein interactions (PPIs) play pivotal roles in the majority of biological processes. Therefore, improved approaches to target and disrupt PPIs would…”
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Selective coordination of three transition metal ions within a coiled-coil peptide scaffold by Boyle, Aimee L, Rabe, Martin, Crone, Niek S. A, Rhys, Guto G, Soler, Nicolas, Voskamp, Patrick, Pannu, Navraj S, Kros, Alexander

“…Designing peptides that fold and assemble in response to metal ions tests our understanding of how peptide folding and metal binding influence one another…”
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How Coiled-Coil Assemblies Accommodate Multiple Aromatic Residues by Rhys, Guto G, Dawson, William M, Beesley, Joseph L, Martin, Freddie J. O, Brady, R. Leo, Thomson, Andrew R, Woolfson, Derek N

“…Rational protein design requires understanding the contribution of each amino acid to a targeted protein fold. For a subset of protein structures, namely,…”
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De Novo-Designed α‑Helical Barrels as Receptors for Small Molecules by Thomas, Franziska, Dawson, William M, Lang, Eric J. M, Burton, Antony J, Bartlett, Gail J, Rhys, Guto G, Mulholland, Adrian J, Woolfson, Derek N

“…We describe de novo-designed α-helical barrels (αHBs) that bind and discriminate between lipophilic biologically active molecules. αHBs have five or more…”
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Artificial, biomimetic and hybrid enzymes: general discussion by Acevedo-Rocha, Carlos, Bakshi, Amulyasai, Bornscheuer, Uwe T, Campopiano, Dominic J, Čivić, Janko, Drienovská, Ivana, Ehinger, Friedrich Johannes, Gomm, Andrew, Góra, Artur, Green, Anthony P, Hanzevacki, Marko, Harvey, Jeremy N, Hilvert, Donald, Huang, Meilan, Jarvis, Amanda G, Kamerlin, Shina Caroline Lynn, Lichtenstein, Bruce R, Luk, Louis Y P, Lutz, Stefan, Marsh, E Neil G, McKenzie, Alexander, Moliner, Vicent, Mulholland, Adrian, Osuna, Sílvia, Pelletier, Joelle N, Raczyńska, Agata, Rao, Aditya Gopalakrishna, Rhys, Guto G, Roelfes, Gerard, Rulíšek, Lubomír, Stockinger, Peter, Szleper, Katarzyna, Thompson, Sean Adeoti, Turner, Nicholas, Van der Kamp, Marc, Xu, Guangcai, Zeymer, Cathleen

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De novo coiled-coil peptides as scaffolds for disrupting protein-protein interactionsElectronic supplementary information (ESI) available. See DOI: 10.1039/c8sc02643b by Fletcher, Jordan M, Horner, Katherine A, Bartlett, Gail J, Rhys, Guto G, Wilson, Andrew J, Woolfson, Derek N

“…Protein-protein interactions (PPIs) play pivotal roles in the majority of biological processes. Therefore, improved approaches to target and disrupt PPIs would…”
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De novo coiled-coil peptides as scaffolds for disrupting protein–protein interactions† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc02643b by Fletcher, Jordan M., Horner, Katherine A., Bartlett, Gail J., Rhys, Guto G., Wilson, Andrew J., Woolfson, Derek N.

“…Homo- and hetero-dimeric coiled coils as scaffolds for the presentation of α-helical protein-binding motifs. Protein–protein interactions (PPIs) play pivotal…”
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Selective coordination of three transition metal ions within a coiled-coil peptide scaffold† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c9sc01165j by Boyle, Aimee L., Rabe, Martin, Crone, Niek S. A., Rhys, Guto G., Soler, Nicolas, Voskamp, Patrick, Pannu, Navraj S., Kros, Alexander

“…Three peptide chains selectively coordinate specific transition metal ions, triggering folding and the formation of a novel metallopeptide complex. Designing…”
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Coiled coils 9-to-5: rational design of α-helical barrels with tunable oligomeric states by Dawson, William M, Martin, Freddie J. O, Rhys, Guto G, Shelley, Kathryn L, Brady, R. Leo, Woolfson, Derek N

“…The rational design of linear peptides that assemble controllably and predictably in water is challenging. Short sequences must encode unique target structures…”
Get full text