Search Results - "Rhost, Sara"

Sortilin inhibition limits secretion-induced progranulin-dependent breast cancer progression and cancer stem cell expansion by Rhost, Sara, Hughes, Éamon, Harrison, Hannah, Rafnsdottir, Svanheidur, Jacobsson, Hanna, Gregersson, Pernilla, Magnusson, Ylva, Fitzpatrick, Paul, Andersson, Daniel, Berger, Karoline, Ståhlberg, Anders, Landberg, Göran

“…Cancer progression is influenced by genetic aberrations in the cancer cell population as well as by other factors including the microenvironment present within…”
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Tumor co-expression of progranulin and sortilin as a prognostic biomarker in breast cancer by Berger, Karoline, Rhost, Sara, Rafnsdóttir, Svanheiður, Hughes, Éamon, Magnusson, Ylva, Ekholm, Maria, Stål, Olle, Rydén, Lisa, Landberg, Göran

“…The growth factor progranulin has been implicated in numerous biological processes such as wound healing, inflammation and progressive tumorigenesis. Both…”
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Patient-derived scaffolds influence secretion profiles in cancer cells mirroring clinical features and breast cancer subtypes by Persson, Emma, Gregersson, Pernilla, Gustafsson, Anna, Fitzpatrick, Paul, Rhost, Sara, Ståhlberg, Anders, Landberg, Göran

“…Breast cancer is a common malignancy with varying clinical behaviors and for the more aggressive subtypes, novel and more efficient therapeutic approaches are…”
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Hypoxia‐induced secretion stimulates breast cancer stem cell regulatory signalling pathways by Jacobsson, Hanna, Harrison, Hannah, Hughes, Éamon, Persson, Emma, Rhost, Sara, Fitzpatrick, Paul, Gustafsson, Anna, Andersson, Daniel, Gregersson, Pernilla, Magnusson, Ylva, Ståhlberg, Anders, Landberg, Göran

“…It is well known that tumour cells are dependent on communication with the tumour microenvironment. Previously, it has been shown that hypoxia (HX) induces…”
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Sulfatide Attenuates Experimental Staphylococcus aureus Sepsis through a CD1d-Dependent Pathway by Kwiecinski, Jakub, Rhost, Sara, Löfbom, Linda, Blomqvist, Maria, Månsson, Jan Eric, Cardell, Susanna L, Jin, Tao

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Multiple tissue-specific isoforms of sulfatide activate CD1d-restricted type II NKT cells by Blomqvist, Maria, Rhost, Sara, Teneberg, Susann, Löfbom, Linda, Østerbye, Thomas, Brigl, Manfred, Månsson, Jan-Eric, Cardell, Susanna L

“…The glycosphingolipid sulfatide (SO₃-3Galβ1Cer) is a demonstrated ligand for a subset of CD1d-restricted NKT cells, which could regulate experimental…”
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CD1d expression in paneth cells and rat exocrine pancreas revealed by novel monoclonal antibodies which differentially affect NKT cell activation by Monzon-Casanova, Elisa, Steiniger, Birte, Schweigle, Stefanie, Clemen, Holger, Zdzieblo, Daniela, Starick, Lisa, Müller, Ingrid, Wang, Chyung-Ru, Rhost, Sara, Cardell, Susanna, Pyz, Elwira, Herrmann, Thomas

“…CD1d is a nonpolymorphic MHC class I-like molecule which presents nonpeptide ligands, e.g. glycolipids, to NKT cells. These cells are known to have multiple…”
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Ap2a2 Is Crucial for LT-HSC Quiescence by Ting, Stephen B, Rhost, Sara, Ghotb, Sarah

“…Despite the relative rarity of haematopoietic stem cells (HSCs) within the blood system, functional heterogeneity is paramount to their ability to sustain…”
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3173 – AP2A2 KO MICE LINK FETAL LIVER HAEMATOPOIESIS EXHAUSTION TO LOSS OF HSC QUIESCENCE, PERTURBED ASYMMETRICAL FATE AND ALTERED LIPID METABOLISM by Ting, Stephen, Rhost, Sara, Saw, Jesslyn, Curtis, David, Magor, Graham, Perkins, Andrew

“…We identified Ap2a2 as an enhancer of mouse long-term (LT-) HSC function via a bone marrow (BM) transplantation screen, and a HSC cell fate determinant during…”
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Interleukin-6 Induces Stem Cell Propagation through Liaison with the Sortilin-Progranulin Axis in Breast Cancer by Berger, Karoline, Persson, Emma, Gregersson, Pernilla, Ruiz-Martínez, Santiago, Jonasson, Emma, Ståhlberg, Anders, Rhost, Sara, Landberg, Göran

“…Unraveling the complex network between cancer cells and their tumor microenvironment is of clinical importance, as it might allow for the identification of new…”
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Defining a novel subset of CD1d‐dependent type II natural killer T cells using natural killer cell‐associated markers by Singh, Avadhesh Kumar, Rhost, Sara, Löfbom, Linda, Cardell, Susanna L.

“…Natural killer T (NKT) cells are αβ T cell receptor (TCR) expressing innate‐like T cells that display natural killer (NK) cell markers. Based on TCR…”
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Reduction of Progranulin-Induced Breast Cancer Stem Cell Propagation by Sortilin-Targeting Cyclotriazadisulfonamide (CADA) Compounds by Berger, Karoline, Pauwels, Eva, Parkinson, Gabrielle, Landberg, Göran, Le, Truc, Demillo, Violeta G, Lumangtad, Liezel A, Jones, Dylan E, Islam, Md Azizul, Olsen, Ryan, Kapri, Topprasad, Intasiri, Amarawan, Vermeire, Kurt, Rhost, Sara, Bell, Thomas W

“…Cyclotriazadisulfonamide (CADA) compounds selectively down-modulate two human proteins of potential therapeutic interest, cluster of differentiation 4 (CD4)…”
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Elucidating the Role of the Endocytic Protein Ap2a2 in Haematopoiesis by Ting, Stephen, Rhost, Sara, Lee, Nicole, Ghotb, Sarah, Meex, Ruth, Watt, Matthew

“…The rare subpopulation of quiescent HSCs exists in limited numbers but upon in vivo requirement have the highest proliferative potency. Self-renewal via…”
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Identification of novel glycolipid ligands activating a sulfatide‐reactive, CD1d‐restricted, type II natural killer T lymphocyte by Rhost, Sara, Löfbom, Linda, Rynmark, Britt‐Marie, Pei, Bo, Månsson, Jan‐Eric, Teneberg, Susann, Blomqvist, Maria, Cardell, Susanna L.

“…Sulfatide‐reactive CD1d‐restricted natural killer T (NKT) lymphocytes belong to the type II NKT cell subset with diverse TCRs, and have been found to regulate…”
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Immunomodulatory Type II Natural Killer T Lymphocytes in Health and Disease by Rhost, S., Sedimbi, S., Kadri, N., Cardell, S. L.

“…Natural killer T (NKT) lymphocytes are αβ T cells activated by lipid‐based ligands presented on the non‐polymorphic CD1d‐molecule. Type I NKT cells that carry…”
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Sulfatide attenuates experimental Staphylococcal aureus sepsis through a CD1d-dependent pathway by Kwiecinski, Jakub, Rhost, Sara, Löfbom, Linda, Blomqvist, Maria K., Månsson, Jan-Eric, Cardell, Susanna, Jin, Tao

“…Natural killer T (NKT) lymphocytes are implicated in the early response to microbial infection. Further, sulfatide, a myelin self-glycosphingolipid, activates…”
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Administration of Sulfatide to Ameliorate Type I Diabetes in Non‐Obese Diabetic Mice by Rhost, S., Löfbom, L., Månsson, J.‐E., Lehuen, A., Blomqvist, M., Cardell, S. L.

“…The endogenous glycosphingolipid sulfatide is a ligand for CD1d‐restricted type II natural killer T (NKT) lymphocytes. Through the action of these cells,…”
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