Search Results - "Rhodes, B."

Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion by Scharping, Nicole E., Rivadeneira, Dayana B., Menk, Ashley V., Vignali, Paolo D. A., Ford, B. Rhodes, Rittenhouse, Natalie L., Peralta, Ronal, Wang, Yiyang, Wang, Yupeng, DePeaux, Kristin, Poholek, Amanda C., Delgoffe, Greg M.

“…Cancer and chronic infections induce T cell exhaustion, a hypofunctional fate carrying distinct epigenetic, transcriptomic and metabolic characteristics…”
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Hypoxia drives CD39-dependent suppressor function in exhausted T cells to limit antitumor immunity by Vignali, Paolo D. A., DePeaux, Kristin, Watson, McLane J., Ye, Chenxian, Ford, B. Rhodes, Lontos, Konstantinos, McGaa, Nicole K., Scharping, Nicole E., Menk, Ashley V., Robson, Simon C., Poholek, Amanda C., Rivadeneira, Dayana B., Delgoffe, Greg M.

“…CD8 + T cells are critical for elimination of cancer cells. Factors within the tumor microenvironment (TME) can drive these cells to a hypofunctional state…”
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Regulation and Immunotherapeutic Targeting of the Epigenome in Exhausted CD8 T Cell Responses by Ford, B Rhodes, Poholek, Amanda C

“…Exhaustion is a state of CD8 T cell differentiation that occurs in settings of chronic Ag such as tumors, chronic viral infection, and autoimmunity. Cellular…”
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Cubilin-, megalin-, and Dab2-dependent transcription revealed by CRISPR/Cas9 knockout in kidney proximal tubule cells by Long, Kimberly R, Rbaibi, Youssef, Bondi, Corry D, Ford, B Rhodes, Poholek, Amanda C, Boyd-Shiwarski, Cary R, Tan, Roderick J, Locker, Joseph D, Weisz, Ora A

“…The multiligand receptors megalin ( ) and cubilin ( ) and their endocytic adaptor protein Dab2 ( ) play essential roles in maintaining the integrity of the…”
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TUBB4B is essential for the expansion of differentiating spermatogonia by Sanzhaeva, Urikhan, Wonsettler, Natalie R., Rhodes, Scott B., Ramamurthy, Visvanathan

“…Microtubules, polymers of αβ-tubulin heterodimers, are essential for various cellular processes. The incorporation of different tubulin isotypes, each encoded…”
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The genetics of SLE: an update in the light of genome-wide association studies by Rhodes, B., Vyse, T. J.

“…Understanding the pathogenesis of SLE remains a considerable challenge. Multiple abnormalities of both the innate and adaptive immune system have been…”
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Tumor microenvironmental signals reshape chromatin landscapes to limit the functional potential of exhausted T cells by Ford, B Rhodes, Vignali, Paolo D A, Rittenhouse, Natalie L, Scharping, Nicole E, Peralta, Ronal, Lontos, Konstantinos, Frisch, Andrew T, Delgoffe, Greg M, Poholek, Amanda C

“…Response rates to immunotherapy in solid tumors remain low due in part to the elevated prevalence of terminally exhausted T cells, a hypofunctional…”
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Elevated PTEN expression maintains anergy in human B cells and reveals unexpectedly high repertoire autoreactivity by Smith, Mia J, Ford, B Rhodes, Rihanek, Marynette, Coleman, Brianne M, Getahun, Andrew, Sarapura, Virginia D, Gottlieb, Peter A, Cambier, John C

“…It has been reported that 2.5%-30% of human peripheral CD27- B cells are autoreactive and anergic based on unresponsiveness to antigen receptor (BCR)…”
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Dysfunction of exhausted T cells is enforced by MCT11-mediated lactate metabolism by Peralta, Ronal M., Xie, Bingxian, Lontos, Konstantinos, Nieves-Rosado, Hector, Spahr, Kellie, Joshi, Supriya, Ford, B. Rhodes, Quann, Kevin, Frisch, Andrew T., Dean, Victoria, Philbin, Mary, Cillo, Anthony R., Gingras, Sebastian, Poholek, Amanda C., Kane, Lawrence P., Rivadeneira, Dayana B., Delgoffe, Greg M.

“…Abstract CD8 + T cells are critical mediators of antitumor immunity but differentiate into a dysfunctional state, known as T cell exhaustion, after persistent…”
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Adverse effects and duration of treatment of TB in Canterbury, New Zealand by Phillipson, J., Kuruppu, N., Chikura, T., McLachlan, C., McNeill, L., Metcalf, S., Pithie, A., Rhodes, B., Dalton, S., Maze, M. J.

“…BACKGROUND Treatment of TB is often extended beyond the recommended duration. The aim of this study was to assess prevalence of extended treatment and to…”
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The complement receptor 3 (CD11b/CD18) agonist Leukadherin‐1 suppresses human innate inflammatory signalling by Roberts, A. L., Fürnrohr, B. G., Vyse, T. J., Rhodes, B.

“…Summary Complement receptor 3 (CR3, CD11b/CD18) is a multi‐functional receptor expressed predominantly on myeloid and natural killer (NK) cells. The R77H…”
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A phase II study of tivozanib in patients with metastatic and nonresectable soft-tissue sarcomas by Agulnik, M., Costa, R.L.B., Milhem, M., Rademaker, A.W., Prunder, B.C., Daniels, D., Rhodes, B.T., Humphreys, C., Abbinanti, S., Nye, L., Cehic, R., Polish, A., Vintilescu, C., McFarland, T., Skubitz, K., Robinson, S., Okuno, S., Van Tine, B.A.

“…Soft tissue sarcomas (STSs) overexpress vascular endothelial growth factors (VEGF) and VEGF-receptors (VEGFR) activation have been associated with tumor…”
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TUBB4B is essential for the cytoskeletal architecture of cochlear supporting cells and motile cilia development by Sanzhaeva, Urikhan, Boyd-Pratt, Helen, Bender, Philip T. R., Saravanan, Thamaraiselvi, Rhodes, Scott B., Guan, Tongju, Billington, Neil, Boye, Shannon E., Cunningham, Christopher L., Anderson, Charles T., Ramamurthy, Visvanathan

“…Microtubules are essential for various cellular processes. The functional diversity of microtubules is attributed to the incorporation of various α- and…”
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Adaptive significance of avian beak morphology for ectoparasite control by Clayton, Dale H, Moyer, Brett R, Bush, Sarah E, Jones, Tony G, Gardiner, David W, Rhodes, Barry B, Goller, Franz

“…) had no effect on feeding efficiency, yet triggered a dramatic increase in feather lice and the feather damage they cause. The overhang functions by…”
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Using physical context for just-in-time information retrieval by Rhodes, B.

“…Jimminy is a wearable personal note-taking and note-archival application that automatically displays notes that might be relevant to the wearer in his current…”
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General aspects of the genetics of SLE by Rhodes, B., Vyse, T. J.

“…The application of genetic techniques to the study of systemic lupus erythematosus (SLE) has identified candidate genes with diverse immunological function…”
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Association of LY9 in UK and Canadian SLE families by Graham, D S Cunninghame, Vyse, T J, Fortin, P R, Montpetit, A, Cai, Y-c, Lim, S, McKenzie, T, Farwell, L, Rhodes, B, Chad, L, Hudson, T J, Sharpe, A, Terhorst, C, Greenwood, C M T, Wither, J, Rioux, J D

“…Systemic lupus erythematosus (SLE) is a complex disease trait of unknown aetiology. Genome-wide linkage studies in human SLE identified several linkage…”
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A Test of the Theory of Reference-Dependent Preferences by Bateman, Ian, Munro, Alistair, Rhodes, Bruce, Starmer, Chris, Sugden, Robert

“…Eight alternative methods of eliciting preferences between money and a consumption good are identified: two of these are standard willingness-to-accept and…”
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The impact of a supplementary medication review and counselling service within the oncology outpatient setting by READ, H, LADDS, S, RHODES, B, BROWN, D, PORTLOCK, J

“…The impact on the care of breast cancer patients, of a pharmacy technician-led medication review and counselling clinic, provided in an outpatient setting, was…”
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Prenylation is essential for the enrichment of cone phosphodiesterase-6 (PDE6) in outer segments and efficient cone phototransduction by Moakedi, Faezeh, Aljammal, Rawaa, Poria, Deepak, Saravanan, Thamaraiselvi, Rhodes, Scott B, Reid, Chyanne, Guan, Tongju, Kefalov, Vladimir J, Ramamurthy, Visvanathan

“…Abstract Phosphodiesterase-6 (PDE6) is the key phototransduction effector enzyme residing in the outer segment (OS) of photoreceptors. Cone PDE6 is a…”
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