Search Results - "Rhoades, Julie A."

Systemic delivery of a Gli inhibitor via polymeric nanocarriers inhibits tumor-induced bone disease by Vanderburgh, Joseph P., Kwakwa, Kristin A., Werfel, Thomas A., Merkel, Alyssa R., Gupta, Mukesh K., Johnson, Rachelle W., Guelcher, Scott A., Duvall, Craig L., Rhoades, Julie A.

“…[Display omitted] Solid tumors frequently metastasize to bone and induce bone destruction leading to severe pain, fractures, and other skeletal-related events…”
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Biphasic α2β1 Integrin Expression in Breast Cancer Metastasis to Bone by Moritz, Milene N O, Merkel, Alyssa R, Feldman, Ean G, Selistre-de-Araujo, Heloisa S, Rhoades Sterling, Julie A

“…Integrins participate in the pathogenesis and progression of tumors at many stages during the metastatic cascade. However, current evidence for the role of…”
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Editorial: Cancer and bone metastasis, volume II by Mandal, Chandi C., Rhoades (Sterling), Julie A.

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Editorial: The Role of Breast Cancer Stem Cells in Clinical Outcomes by Raman, Dayanidhi, Tiwari, Amit K, Tiriveedhi, Venkataswarup, Rhoades Sterling, Julie A

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Targeting hedgehog-driven mechanisms of drug-resistant cancers by Miller, Jade S, Bennett, Natalie E, Rhoades, Julie A

“…Due to the cellular plasticity that is inherent to cancer, the acquisition of resistance to therapy remains one of the biggest obstacles to patient care. In…”
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3D Bone Morphology Alters Gene Expression, Motility, and Drug Responses in Bone Metastatic Tumor Cells by Dadwal, Ushashi C, Merkel, Alyssa R, Page, Jonathan M, Kwakwa, Kristin A, Kessler, Michael, Rhoades, Julie A

“…Patients with advanced skeletal metastases arising from primary cancers including breast, lung, and prostate suffer from extreme pain, bone loss, and frequent…”
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Tuning Ligand Density To Optimize Pharmacokinetics of Targeted Nanoparticles for Dual Protection against Tumor-Induced Bone Destruction by Vanderburgh, Joseph, Hill, Jordan L, Gupta, Mukesh K, Kwakwa, Kristin A, Wang, Sean K, Moyer, Kathleen, Bedingfield, Sean K, Merkel, Alyssa R, d’Arcy, Richard, Guelcher, Scott A, Rhoades, Julie A, Duvall, Craig L

“…Breast cancer patients are at high risk for bone metastasis. Metastatic bone disease is a major clinical problem that leads to a reduction in mobility,…”
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Bioinformatics Screen Reveals Gli-Mediated Hedgehog Signaling as an Associated Pathway to Poor Immune Infiltration of Dedifferentiated Liposarcoma by Beadle, Erik P, Bennett, Natalie E, Rhoades, Julie A

“…Liposarcomas are the most diagnosed soft tissue sarcoma, with most cases consisting of well-differentiated (WDLPS) or dedifferentiated (DDLPS) histological…”
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Pharmacologic Hedgehog inhibition modulates the cytokine profile of osteolytic breast cancer cells by Bennett, Natalie E., Parker, Dominique V., Mangano, Rachel S., Baum, Jennifer E., Northcutt, Logan A., Miller, Jade S., Beadle, Erik P., Rhoades, Julie A.

“…•Gli2 correlates with myeloid gene signatures in sequencing data of patient tumors.•HPI-1 treatment alters transcription and secretion of cytokines, including…”
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A Perfusion Bioreactor Model of Tumor-Induced Bone Disease Using Human Cells by Lowen, Gregory B, Vanderburgh, Joseph P, Florian, David, Scott, Taylor, Sterling, Julie A Rhoades, Guelcher, Scott A

“…Advanced solid tumors often metastasize to bone. Once established in bone, these tumors can induce bone destruction resulting in decreased quality of life and…”
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Nanoparticle STING Agonist Reprograms the Bone Marrow to an Antitumor Phenotype and Protects Against Bone Destruction by Florian, David C, Bennett, Natalie E, Odziomek, Mateusz, Baljon, Jessalyn J, Wehbe, Mohamed, Merkel, Alyssa R, Fischer, Melissa A, Savona, Michael R, Rhoades, Julie A, Guelcher, Scott A, Wilson, John T

“…When breast cancer metastasizes to bone, treatment options are limited. Failure to treat bone metastases is thought to be due to therapy-resistant features of…”
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Pilot study of a high-frequency school-based hearing screen to detect adolescent hearing loss by Sekhar, Deepa L, Zalewski, Thomas R, Ghossaini, Soha N, King, Tonya S, Rhoades, Julie A, Czarnecki, Beth, Grounds, Shannon, Deese, Barry, Barr, Ashley L, Paul, Ian M

“…Like most of the United States, school-based hearing screening in Pennsylvania focuses on low-frequency, conductive hearing losses typical for young children,…”
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Abstract 2728: Modulation of NFkappaB signaling influences tumor associated macrophage phenotypes in murine models of breast cancer by Bullock, Kennady K., Parker, Dominique, Glass, Evan B., Hoover, Alyssa, Merkel, Alyssa, Maynard, Richard, Wilson, Andrew, Giorgio, Todd, Rhoades, Julie A., Yull, Fiona E.

“…Tumor associated macrophages (TAMs) often exist in high densities in breast tumors and are associated with adverse clinical outcomes. TAM repolarization as a…”
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Improving detection of adolescent hearing loss by Sekhar, Deepa L, Rhoades, Julie A, Longenecker, Amy L, Beiler, Jessica S, King, Tonya S, Widome, Mark D, Paul, Ian M

“…To compare a protocol for pure-tone threshold testing, capable of detecting high-frequency hearing loss as indicated by notched audiometric configurations,…”
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