Analysis of the influence of glutathione S-transferase (GSTM1 and GSTT1) genes on the risk of essential hypertension

Analysis of the influence of glutathione S-transferase (GSTM1 and GSTT1) genes on the risk of essential hypertension

Essential hypertension (EH) results from a complex interaction between environmental factors and an individual's genetic background. To assess the relationship between polymorphisms in GSTM1 and GSTT1 and the risk of EH. A multiplex-PCR was used to identify the genotypic profiles of GSTM1 and G...

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Bibliographic Details
Published in:Annals of human biology Vol. 48; no. 7-8; pp. 585 - 589
Main Authors: Nassereddine, Sanaa, Habbal, Rachida, Kassogue, Yaya, Kaltoum, Ait Boujmia Oum, Farah, Korchi, Majda, Haraka, Rhizlane, Abou Elfath, Nadifi, Sellama, Dehbi, Hind
Format: Journal Article
Language:English
Published: England Taylor & Francis 17-11-2021
Taylor & Francis Group
Subjects:
Case-Control Studies
essential hypertension
Essential Hypertension - genetics
Genetic Predisposition to Disease
Genotype
Glutathione S-transferase
Glutathione Transferase - genetics
GSTM1
GSTT1
Humans
Middle Aged
Morocco
Polymorphism, Genetic
Risk Factors
essential hypertension
GSTT1
GSTM1
Morocco
Glutathione S-transferase
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Summary:Essential hypertension (EH) results from a complex interaction between environmental factors and an individual's genetic background. To assess the relationship between polymorphisms in GSTM1 and GSTT1 and the risk of EH. A multiplex-PCR was used to identify the genotypic profiles of GSTM1 and GSTT1 in 160 patients and 210 controls. The frequency of GSTM1-null genotype was higher in patients younger than 61 years when compared to those over 61 years. Interestingly, GSTT1-null was significantly associated with the risk of EH (OR 4; 95% CI 2.6-6.3; p < 0.0001). While GSTM1-null showed no trend (OR 0.7; 95% CI 0.5-1.1, p = 0.12). Individuals carrying the combined GSTT1-null/GSTM1-null were 2.4 times more at risk for hypertension compared to those harbouring the combined GSTT1-present/GSTM1-present genotype (OR 2.4; 95% CI 1.3-4.4; p = 0.005). Additionally, the presence of the combined GSTT1-null/GSTM1-present was associated with an increased risk of EH compared to GSTT1-present/GSTM1-present carriers (OR 6.75; 95% CI 3.4-13.2; p < 0.0001). This study showed that the GSTT1-null alone or in interaction with GSTM1-present or GSTM1-null was associated with a higher risk of hypertension. Moreover, the GSTM1-null seems to be associated with the age of onset of hypertension.
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ISSN:0301-4460
1464-5033
DOI:10.1080/03014460.2022.2039291