Search Results - "Rheinallt M. Jones"

The gut-bone axis: how bacterial metabolites bridge the distance by Zaiss, Mario M, Jones, Rheinallt M, Schett, Georg, Pacifici, Roberto

“…The gut microbiome is a key regulator of bone health that affects postnatal skeletal development and skeletal involution. Alterations in microbiota composition…”
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Sex steroid deficiency-associated bone loss is microbiota dependent and prevented by probiotics by Li, Jau-Yi, Chassaing, Benoit, Tyagi, Abdul Malik, Vaccaro, Chiara, Luo, Tao, Adams, Jonathan, Darby, Trevor M, Weitzmann, M Neale, Mulle, Jennifer G, Gewirtz, Andrew T, Jones, Rheinallt M, Pacifici, Roberto

“…A eubiotic microbiota influences many physiological processes in the metazoan host, including development and intestinal homeostasis. Here, we have shown that…”
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Indoles from the commensal microbiota act via the AHR and IL-10 to tune the cellular composition of the colonic epithelium during aging by Powell, Domonica N., Swimm, Alyson, Sonowal, Robert, Bretin, Alexis, Gewirtz, Andrew T., Jones, Rheinallt M., Kalman, Daniel

“…The intestinal epithelium is a highly dynamic structure that rejuvenates in response to acute stressors and can undergo alterations in cellular composition as…”
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Gut-Resident Lactobacilli Activate Hepatic Nrf2 and Protect Against Oxidative Liver Injury by Saeedi, Bejan J., Liu, Ken H., Owens, Joshua A., Hunter-Chang, Sarah, Camacho, Mary C., Eboka, Richard U., Chandrasekharan, Bindu, Baker, Nusaiba F., Darby, Trevor M., Robinson, Brian S., Jones, Rheinallt M., Jones, Dean P., Neish, Andrew S.

“…Many studies have suggested a role for gut-resident microbes (the “gut microbiome”) in modulating host health; however, the mechanisms by which they impact…”
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Osteomicrobiology: The influence of gut microbiota on bone in health and disease by Jones, Rheinallt M, Mulle, Jennifer G, Pacifici, Roberto

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PTH induces bone loss via microbial-dependent expansion of intestinal TNF+ T cells and Th17 cells by Yu, Mingcan, Malik Tyagi, Abdul, Li, Jau-Yi, Adams, Jonathan, Denning, Timothy L., Weitzmann, M. Neale, Jones, Rheinallt M., Pacifici, Roberto

“…Bone loss is a frequent but not universal complication of hyperparathyroidism. Using antibiotic-treated or germ-free mice, we show that parathyroid hormone…”
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Lactobacilli Modulate Epithelial Cytoprotection through the Nrf2 Pathway by Jones, Rheinallt M., Desai, Chirayu, Darby, Trevor M., Luo, Liping, Wolfarth, Alexandra A., Scharer, Christopher D., Ardita, Courtney S., Reedy, April R., Keebaugh, Erin S., Neish, Andrew S.

“…An optimal gut microbiota influences many beneficial processes in the metazoan host. However, the molecular mechanisms that mediate and function in…”
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Callus γδ T cells and microbe-induced intestinal Th17 cells improve fracture healing in mice by Dar, Hamid Y, Perrien, Daniel S, Pal, Subhashis, Stoica, Andreea, Uppuganti, Sasidhar, Nyman, Jeffry S, Jones, Rheinallt M, Weitzmann, M Neale, Pacifici, Roberto

“…IL-17A (IL-17), a driver of the inflammatory phase of fracture repair, is produced locally by several cell lineages including γδ T cells and Th17 cells…”
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The microbiome restrains melanoma bone growth by promoting intestinal NK and Th1 cell homing to bone by Pal, Subhashis, Perrien, Daniel S, Yumoto, Tetsuya, Faccio, Roberta, Stoica, Andreea, Adams, Jonathan, Coopersmith, Craig M, Jones, Rheinallt M, Weitzmann, M Neale, Pacifici, Roberto

“…Bone metastases are frequent complications of malignant melanoma leading to reduced quality of life and significant morbidity. Regulation of immune cells by…”
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Epithelial adhesion mediated by pilin SpaC is required for Lactobacillus rhamnosus GG-induced cellular responses by Ardita, Courtney S, Mercante, Jeffrey W, Kwon, Young Man, Luo, Liping, Crawford, Madelyn E, Powell, Domonica N, Jones, Rheinallt M, Neish, Andrew S

“…Lactobacillus rhamnosus GG is a widely used probiotic, and the strain's salutary effects on the intestine have been extensively documented. We previously…”
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Enteric Commensal Bacteria Induce Extracellular Signal-regulated Kinase Pathway Signaling via Formyl Peptide Receptor-dependent Redox Modulation of Dual Specific Phosphatase 3 by Wentworth, Christy C., Alam, Ashfaqul, Jones, Rheinallt M., Nusrat, Asma, Neish, Andrew S.

“…The normal microbial occupants of the mammalian intestine are crucial for maintaining gut homeostasis, yet the mechanisms by which intestinal cells perceive…”
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The gut microbiota is a transmissible determinant of skeletal maturation by Tyagi, Abdul Malik, Darby, Trevor M, Hsu, Emory, Yu, Mingcan, Pal, Subhashis, Dar, Hamid, Li, Jau-Yi, Adams, Jonathan, Jones, Rheinallt M, Pacifici, Roberto

“…Genetic factors account for the majority of the variance of human bone mass, but the contribution of non-genetic factors remains largely unknown. By utilizing…”
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At the heart of microbial conversations: endocannabinoids and the microbiome in cardiometabolic risk by Khan, Ramsha Nabihah, Maner-Smith, Kristal, A. Owens, Joshua, Barbian, Maria Estefania, Jones, Rheinallt M., R. Naudin, Crystal

“…Cardiometabolic syndrome encompasses intertwined risk factors such as hypertension, dyslipidemia, elevated triglycerides, abdominal obesity, and other…”
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A high fiber diet or supplementation with Lactococcus lactis subspecies cremoris to pregnant mice confers protection against intestinal injury in adult offspring by Barbian, Maria E, Owens, Joshua A, Naudin, Crystal R, Denning, Patricia, Patel, Ravi M, Jones, Rheinallt M

“…The diet during pregnancy, or antenatal diet, influences the offspring's intestinal health. We previously showed that antenatal butyrate supplementation…”
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Cruciferous vegetables ( Brassica oleracea ) confer cytoprotective effects in Drosophila intestines by Lyles, James T, Luo, Liping, Liu, Ken, Jones, Dean P, Jones, Rheinallt M, Quave, Cassandra L

“…Varieties and cultivars of the cruciferous vegetable are widely presumed to elicit positive influences on mammalian health and disease, particularly related to…”
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Lactococcus Lactis Subsp. cremoris Is an Efficacious Beneficial Bacterium that Limits Tissue Injury in the Intestine by Darby, Trevor M, Owens, Joshua A, Saeedi, Bejan J, Luo, Liping, Matthews, Jason D, Robinson, Brian S, Naudin, Crystal R, Jones, Rheinallt M

“…The use of beneficial bacteria to promote health is widely practiced. However, experimental evidence corroborating the efficacy of bacteria promoted with such…”
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A Human Microbiota-Associated Murine Model for Assessing the Impact of the Vaginal Microbiota on Pregnancy Outcomes by Wolfarth, Alexandra A, Smith, Taylor M, VanInsberghe, David, Dunlop, Anne Lang, Neish, Andrew S, Corwin, Elizabeth J, Jones, Rheinallt M

“…Disease states are often linked to large scale changes in microbial community structure that obscure the contributions of individual microbes to disease…”
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Recognition of bacterial pathogens and mucosal immunity by Jones, Rheinallt M., Neish, Andrew S.

“…Summary Rapid detection and elimination of pathogens invasive to intestinal tissue is essential to avoid prolonged gut inflammation, or systemic sepsis. The…”
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Intestinal barrier dysfunction in murine sickle cell disease is associated with small intestine neutrophilic inflammation, oxidative stress, and dysbiosis by Lewis, Caitlin V., Sellak, Hassan, Sawan, Mariem A., Joseph, Giji, Darby, Trevor M., VanInsberghe, David, Naudin, Crystal R., Archer, David R., Jones, Rheinallt M., Taylor, W. Robert

“…The intestinal microbiome has emerged as a potential contributor to the severity of sickle cell disease (SCD). We sought to determine whether SCD mice exhibit…”
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Redox signaling mediated by the gut microbiota by Jones, Rheinallt M., Neish, Andrew S.

“…The microbiota that inhabits the mammalian intestine can influence a range of physiological functions, including the modulation of immune responses,…”
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