Search Results - "Rhéaume, Eric"

Lipoprotein(a) levels, genotype, and incident aortic valve stenosis: a prospective Mendelian randomization study and replication in a case-control cohort by Arsenault, Benoit J, Boekholdt, S Matthijs, Dubé, Marie-Pierre, Rhéaume, Eric, Wareham, Nicholas J, Khaw, Kay-Tee, Sandhu, Manjinder S, Tardif, Jean-Claude

“…Although a previous study has suggested that a genetic variant in the LPA region was associated with the presence of aortic valve stenosis (AVS), no…”
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Role of Noncanonical Wnt Signaling Pathway in Human Aortic Valve Calcification by Albanese, Isabella, Yu, Bin, Al-Kindi, Hamood, Barratt, Bianca, Ott, Leah, Al-Refai, Mohammad, de Varennes, Benoit, Shum-Tim, Dominique, Cerruti, Marta, Gourgas, Ophélie, Rhéaume, Eric, Tardif, Jean-Claude, Schwertani, Adel

“…OBJECTIVE—The mechanisms underlying the pathogenesis of aortic valve calcification remain unclear. With accumulating evidence demonstrating that valve…”
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Colchicine reduces lung injury in experimental acute respiratory distress syndrome by Dupuis, Jocelyn, Sirois, Martin G, Rhéaume, Eric, Nguyen, Quang T, Clavet-Lanthier, Marie-Élaine, Brand, Genevieve, Mihalache-Avram, Teodora, Théberge-Julien, Gabriel, Charpentier, Daniel, Rhainds, David, Neagoe, Paul-Eduard, Tardif, Jean-Claude

“…The acute respiratory distress syndrome (ARDS) is characterized by intense dysregulated inflammation leading to acute lung injury (ALI) and respiratory…”
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Cardiac inflammation and diastolic dysfunction in hypercholesterolemic rabbits by Nachar, Walid, Merlet, Nolwenn, Maafi, Foued, Shi, Yanfen, Mihalache-Avram, Teodora, Mecteau, Mélanie, Ferron, Marine, Rhéaume, Eric, Tardif, Jean-Claude

“…Left ventricular diastolic dysfunction (LVDD) is present in more than 50% of patients suffering from heart failure. LVDD animal models are limited and its…”
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Dalcetrapib and anacetrapib increase apolipoprotein E-containing HDL in rabbits and humans by Brodeur, Mathieu R., Rhainds, David, Charpentier, Daniel, Boulé, Marie, Mihalache-Avram, Téodora, Mecteau, Mélanie, Brand, Geneviève, Pedneault-Gagnon, Valérie, Fortier, Annik, Niesor, Eric J., Rhéaume, Eric, Maugeais, Cyrille, Tardif, Jean-Claude

“…The large HDL particles generated by administration of cholesteryl ester transfer protein inhibitors (CETPi) remain poorly characterized, despite their…”
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Inhibition of the 3CL Protease and SARS-CoV‑2 Replication by Dalcetrapib by Niesor, Eric J, Boivin, Guy, Rhéaume, Eric, Shi, Rong, Lavoie, Véronique, Goyette, Nathalie, Picard, Marie-Eve, Perez, Anne, Laghrissi-Thode, Fouzia, Tardif, Jean-Claude

“…The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) 3CL protease is a promising target for inhibition of viral replication by interaction with a…”
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Dalcetrapib and anacetrapib differently impact HDL structure and function in rabbits and monkeys by Brodeur, Mathieu R., Rhainds, David, Charpentier, Daniel, Mihalache-Avram, Teodora, Mecteau, Mélanie, Brand, Geneviève, Chaput, Evelyne, Perez, Anne, Niesor, Eric J., Rhéaume, Eric, Maugeais, Cyrille, Tardif, Jean-Claude

“…Inhibition of cholesteryl ester transfer protein (CETP) increases HDL cholesterol (HDL-C) levels. However, the circulating CETP level varies and the impact of…”
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Adcy9 Gene Inactivation Improves Cardiac Function After Myocardial Infarction in Mice by Ferron, Marine, Merlet, Nolwenn, Mihalache-Avram, Teodora, Mecteau, Mélanie, Brand, Geneviève, Gillis, Marc-Antoine, Shi, Yanfen, Nozza, Anna, Cossette, Mariève, Guertin, Marie-Claude, Rhéaume, Eric, Tardif, Jean-Claude

“…Polymorphisms in the adenylate cyclase 9 (ADCY9) gene influence the benefits of the cholesteryl ester transfer protein (CETP) modulator dalcetrapib on…”
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Significance of the Wnt signaling pathway in coronary artery atherosclerosis by Khan, Kashif, Yu, Bin, Tardif, Jean-Claude, Rhéaume, Eric, Al-Kindi, Hamood, Filimon, Sabin, Pop, Cristina, Genest, Jacques, Cecere, Renzo, Schwertani, Adel

“…The progression of coronary atherosclerosis is an active and regulated process. The Wnt signaling pathway is thought to play an active role in the pathogenesis…”
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Evaluation of Links Between High-Density Lipoprotein Genetics, Functionality, and Aortic Valve Stenosis Risk in Humans by Arsenault, Benoit J, Dubé, Marie-Pierre, Brodeur, Mathieu R, de Oliveira Moraes, Adriana Benjamin, Lavoie, Véronique, Kernaleguen, Anne-Elen, Guauque-Olarte, Sandra, Mathieu, Patrick, Pibarot, Philippe, Messika-Zeitoun, David, Bossé, Yohan, Rhainds, David, Rhéaume, Éric, Tardif, Jean-Claude

“…OBJECTIVE—Studies have shown that high-density lipoprotein (HDL)–raising compounds induce regression of aortic valve stenosis (AVS) in animal models. However,…”
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Elevated level of lecithin:cholesterol acyltransferase (LCAT) is associated with reduced coronary atheroma burden by Gebhard, Catherine, Rhainds, David, He, Gang, Rodés-Cabau, Josep, Lavi, Shahar, Spence, J. David, Title, Lawrence, Kouz, Simon, L'Allier, Philippe L., Grégoire, Jean, Ibrahim, Reda, Cossette, Mariève, Guertin, Marie-Claude, Beanlands, Robert, Rhéaume, Eric, Tardif, Jean-Claude

“…Lecithin:cholesterol acyltransferase (LCAT), a key enzyme in high-density lipoprotein (HDL) metabolism and reverse cholesterol transport (RCT), has been…”
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ApoA-I mimetic does not improve left ventricular diastolic dysfunction in rabbits without aortic valve stenosis by Nachar, Walid, Merlet, Nolwenn, Maafi, Foued, Mihalache-Avram, Teodora, Mecteau, Mélanie, Gélinas, Danielle, Shi, Yanfen, Brodeur, Mathieu, Alem, Sonia, Blondeau, Lucie, Cossette, Mariève, Guertin, Marie-Claude, Rhainds, David, Busseuil, David, Rhéaume, Eric, Tardif, Jean-Claude

“…We previously demonstrated that high-density lipoprotein (HDL) infusions may improve left ventricular diastolic dysfunction (LVDD) in an aortic valve stenosis…”
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Optimisation of reference genes for gene-expression analysis in a rabbit model of left ventricular diastolic dysfunction by Nachar, Walid, Busseuil, David, Shi, Yanfen, Mihalache-Avram, Teodora, Mecteau, Mélanie, Rhéaume, Eric, Tardif, Jean-Claude

“…Left ventricular diastolic dysfunction (LVDD) is characterized by the disturbance of ventricle's performance due to its abnormal relaxation or to its increased…”
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Beneficial Effects of Reconstituted High-Density Lipoprotein (rHDL) on Circulating CD34+ Cells in Patients after an Acute Coronary Syndrome by Gebhard, Catherine, Rhéaume, Eric, Berry, Colin, Brand, Geneviève, Kernaleguen, Anne-Elen, Théberge-Julien, Gabriel, Alam, Mohammad Afaque, Lee, Candace Y W, Boileau, Laurianne, Chabot-Blanchet, Malorie, Guertin, Marie-Claude, Lavoie, Marc-André, Grégoire, Jean, Ibrahim, Réda, L'Allier, Philippe, Tardif, Jean-Claude

“…High-density lipoproteins (HDL) favorably affect endothelial progenitor cells (EPC). Circulating progenitor cell level and function are impaired in patients…”
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Variants at the APOE /C1/C2/C4 Locus Modulate Cholesterol Efflux Capacity Independently of High-Density Lipoprotein Cholesterol by Low-Kam, Cécile, Rhainds, David, Lo, Ken Sin, Barhdadi, Amina, Boulé, Marie, Alem, Sonia, Pedneault-Gagnon, Valérie, Rhéaume, Eric, Dubé, Marie-Pierre, Busseuil, David, Hegele, Robert A, Lettre, Guillaume, Tardif, Jean-Claude

“…Background Macrophage cholesterol efflux to high-density lipoproteins ( HDLs ) is the first step of reverse cholesterol transport. The cholesterol efflux…”
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Colchicine reduces atherosclerotic plaque vulnerability in rabbits by Roubille, François, Merlet, Nolwenn, Busseuil, David, Ferron, Marine, Shi, Yanfen, Mihalache-Avram, Teodora, Mecteau, Mélanie, Brand, Geneviève, Rivas, Daniel, Cossette, Mariève, Guertin, Marie-Claude, Rhéaume, Eric, Tardif, Jean-Claude

“…The anti-inflammatory agent colchicine is gaining interest as a treatment for coronary artery disease. However, the effects of colchicine in atherosclerotic…”
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Validating a bimodal intravascular ultrasound (IVUS) and near-infrared fluorescence (NIRF) catheter for atherosclerotic plaque detection in rabbits by Abran, Maxime, Stähli, Barbara E, Merlet, Nolwenn, Mihalache-Avram, Teodora, Mecteau, Mélanie, Rhéaume, Eric, Busseuil, David, Tardif, Jean-Claude, Lesage, Frédéric

“…Coronary artery disease is characterized by atherosclerotic plaque formation. Despite impressive advances in intravascular imaging modalities, in vivo…”
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A sex-specific evolutionary interaction between ADCY9 and CETP by Gamache, Isabel, Legault, Marc-André, Grenier, Jean-Christophe, Sanchez, Rocio, Rhéaume, Eric, Asgari, Samira, Barhdadi, Amina, Zada, Yassamin Feroz, Trochet, Holly, Luo, Yang, Lecca, Leonid, Murray, Megan, Raychaudhuri, Soumya, Tardif, Jean-Claude, Dubé, Marie-Pierre, Hussin, Julie

“…Pharmacogenomic studies have revealed associations between rs1967309 in the adenylyl cyclase type 9 ( ) gene and clinical responses to the cholesteryl ester…”
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VCAM-1-targeting gold nanoshell probe for photoacoustic imaging of atherosclerotic plaque in mice by Rouleau, Leonie, Berti, Romain, Ng, Vanessa W K, Matteau-Pelletier, Carl, Lam, Tina, Saboural, Pierre, Kakkar, Ashok K, Lesage, Frédéric, Rhéaume, Eric, Tardif, Jean-Claude

“…The development of molecular probes and novel imaging modalities, allowing better resolution and specificity, is associated with an increased potential for…”
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Development of a new bioactivatable fluorescent probe for quantification of apolipoprotein A-I proteolytic degradation in vitro and in vivo by Maafi, Foued, Li, Baoqiang, Gebhard, Catherine, Brodeur, Mathieu R, Nachar, Walid, Villeneuve, Louis, Lesage, Frédéric, Rhainds, David, Rhéaume, Eric, Tardif, Jean-Claude

“…Abstract Background and aims The potential benefits of high-density lipoproteins (HDL) against atherosclerosis are attributed to its major protein component,…”
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