Search Results - "Rezvanian, Sepideh"
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Symptomatic and neurotrophic effects of GABAA receptor positive allosteric modulation in a mouse model of chronic stress
Published in Neuropsychopharmacology (New York, N.Y.) (01-08-2022)“…Chronic stress is a risk factor for Major Depressive Disorder (MDD), and in rodents, it recapitulates human behavioral, cellular and molecular changes. In MDD…”
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Rationalizing the binding and α subtype selectivity of synthesized imidazodiazepines and benzodiazepines at GABAA receptors by using molecular docking studies
Published in Bioorganic & medicinal chemistry letters (15-04-2022)“…[Display omitted] The pharmacological actions exerted by benzodiazepines are dependent on the discrete α protein subunits of the γ-aminobutyric acid type A…”
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GABA(A) Receptor Activation Drives GABARAP-Nix Mediated Autophagy to Radiation-Sensitize Primary and Brain-Metastatic Lung Adenocarcinoma Tumors
Published in Cancers (15-09-2024)“…In non-small cell lung cancer (NSCLC) treatment, radiotherapy responses are not durable and toxicity limits therapy. We find that AM-101, a synthetic…”
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New Imidazodiazepine Analogue, 5-(8-Bromo-6-(pyridin-2-yl)-4 H -benzo[ f ]imidazo[1,5- a ][1,4]diazepin-3-yl)oxazole, Provides a Simplified Synthetic Scheme, High Oral Plasma and Brain Exposures, and Produces Antiseizure Efficacy in Mice, and Antiepileptogenic Activity in Neural Networks in Brain Slices from a Patient with Mesial Temporal Lobe Epilepsy
Published in ACS chemical neuroscience (07-02-2024)“…KRM-II-81 (1) is an imidazodiazepine GABA receptor (GABAAR) potentiator with broad antiseizure efficacy and a low sedative burden. A brominated analogue,…”
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New Imidazodiazepine Analogue, 5‑(8-Bromo-6-(pyridin-2-yl)‑4H‑benzo[f]imidazo[1,5‑a][1,4]diazepin-3-yl)oxazole, Provides a Simplified Synthetic Scheme, High Oral Plasma and Brain Exposures, and Produces Antiseizure Efficacy in Mice, and Antiepileptogenic Activity in Neural Networks in Brain Slices from a Patient with Mesial Temporal Lobe Epilepsy
Published in ACS chemical neuroscience (07-02-2024)“…KRM-II-81 (1) is an imidazodiazepine GABAA receptor (GABAAR) potentiator with broad antiseizure efficacy and a low sedative burden. A brominated analogue,…”
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Abstract 703: GABA(A) receptor activation drives GABARAP-Nix mediated autophagy to radiosensitize primary and metastatic lung adenocarcinoma tumors
Published in Cancer research (Chicago, Ill.) (22-03-2024)“…In non-small cell lung cancer (NSCLC) treatment, targeted therapies help a subset of patients, and radiotherapy responses are not durable and toxicity limits…”
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An efficient debromination technique using PMHS with a number of ligands containing different functional groups
Published in ARKIVOC free online journal of organic chemistry (01-01-2021)“…Herein is described the strategy to debrominate different aryl bromides selectively, using polymethylhydrosiloxane (PMHS) which tolerates a variety of…”
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Design, synthesis and characterization of novel gamma‑aminobutyric acid type A receptor ligands
Published in ARKIVOC free online journal of organic chemistry (01-01-2020)“…Antinociceptive ligand HZ-166 is a GABA α2/α3 receptor subtype-selective potentiator. It has been shown to exhibit anxiolytic-like effects in rodent and rhesus…”
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