Search Results - "Reznik, Vladimir S"

Slow-binding inhibition of acetylcholinesterase by an alkylammonium derivative of 6-methyluracil: mechanism and possible advantages for myasthenia gravis treatment by Kharlamova, Alexandra D, Lushchekina, Sofya V, Petrov, Konstantin A, Kots, Ekaterina D, Nachon, Florian, Villard-Wandhammer, Marielle, Zueva, Irina V, Krejci, Eric, Reznik, Vladimir S, Zobov, Vladimir V, Nikolsky, Evgeny E, Masson, Patrick

“…Inhibition of human AChE (acetylcholinesterase) and BChE (butyrylcholinesterase) by an alkylammonium derivative of 6-methyluracil, C-547, a potential drug for…”
Get more information

6-Methyluracil Derivatives as Bifunctional Acetylcholinesterase Inhibitors for the Treatment of Alzheimer's Disease by Semenov, Vyacheslav E., Zueva, Irina V., Mukhamedyarov, Marat A., Lushchekina, Sofya V., Kharlamova, Alexandra D., Petukhova, Elena O., Mikhailov, Anatoly S., Podyachev, Sergey N., Saifina, Lilya F., Petrov, Konstantin A., Minnekhanova, Oksana A., Zobov, Vladimir V., Nikolsky, Evgeny E., Masson, Patrick, Reznik, Vladimir S.

“…Novel 6‐methyluracil derivatives with ω‐(substituted benzylethylamino)alkyl chains at the nitrogen atoms of the pyrimidine ring were designed and synthesized…”
Get full text

Hydrogen's isotopic exchange reaction in the C‐methyl sides in the medicinal agent xymedon: NMR spectroscopy and ab initio calculations by Latypov, Shamil K., Kondrashova, Svetlana A., Galyametdinova, Irina V., Semenov, Vyacheslav E., Reznik, Vladimir S.

“…The kinetics of intramolecular and intermolecular exchange processes in xymedon (1‐(2‐hydroxyethyl)‐4,6‐dimethyl‐1,2‐dihydropyrimidin‐2‐one, a regeneratory,…”
Get full text

Effect of tissue-specific acetylcholinesterase inhibitor C-547 on α3β4 and αβεδ acetylcholine receptors in COS cells by Lindovský, Jiří, Petrov, Konstantin, Krůšek, Jan, Reznik, Vladimir S., Nikolsky, Eugeny E., Vyskočil, František

“…The C-547 is the most effective muscle and tissue-specific anticholinesterase among alkylammonium derivatives of 6-methyluracil (ADEMS) acting in nanomolar…”
Get full text

Antimicrobial activity of pyrimidinophanes with thiocytosine and uracil moieties by Semenov, Vyacheslav E., Mikhailov, Anatoly S., Voloshina, Alexandra D., Kulik, Natalia V., Nikitashina, Alexandra D., Zobov, Vladimir V., Kharlamov, Sergey V., Latypov, Shamil K., Reznik, Vladimir S.

“…Reactions of pyrimidinophanes with two 6-methylthiocytosine and one 5(6)-alkyluracil moieties bridged with each other by polymethylene spacers with methyl or…”
Get full text

Tunable biomimetic systems based on a novel amphiphilic pyrimidinophane and a helper nonionic surfactant by Kharlamov, Sergey V., Voronin, Mikhail A., Semenov, Vyacheslav E., Gabdrakhmanov, Dinar R., Strobykina, Anastasiya S., Nikolaev, Anton E., Reznik, Vladimir S., Zakharova, Lucia Ya, Konovalov, Alexander I.

“…•Tunable nanosystems based on a water insoluble pyrimidinic amphiphile are designed.•Nonionic surfactant Triton-X-100 increases mixed aggregate stability.•New…”
Get full text

Novel Bolaamphiphilic Pyrimidinophane As Building Block for Design of Nanosized Supramolecular Systems with Concentration-Dependent Structural Behavior by Voronin, Mikhail A, Gabdrakhmanov, Dinar R, Semenov, Vyacheslav E, Valeeva, Farida G, Mikhailov, Anatoly S, Nizameev, Irek R, Kadirov, Marsil K, Zakharova, Lucia Ya, Reznik, Vladimir S, Konovalov, Alexander I

“…A new macrocyclic bolaamphiphile with thiocytosine fragments in the molecule (B1) has been synthesized and advanced as perspective platform for the design of…”
Get full text

Different sensitivities of rat skeletal muscles and brain to novel anti‐cholinesterase agents, alkylammonium derivatives of 6‐methyluracil (ADEMS) by Petrov, Konstantin A, Yagodina, Lilia O, Valeeva, Guzel R, Lannik, Natalya I, Nikitashina, Alexandra D, Rizvanov, Albert A, Zobov, Vladimir V, Bukharaeva, Ellya A, Reznik, Vladimir S, Nikolsky, Eugeny E, Vyskočil, František

“…BACKGROUND AND PURPOSE The rat respiratory muscle diaphragm has markedly lower sensitivity than the locomotor muscle extensor digitorum longus (EDL) to the new…”
Get full text

Nanoreactors Based on Amphiphilic Uracilophanes:  Self-Organization and Reactivity Study by Zakharova, Lucia Ya, Semenov, Vyacheslav E, Voronin, Mikhail A, Valeeva, Farida G, Ibragimova, Alsu R, Giniatullin, Rashid Kh, Chernova, Alla V, Kharlamov, Sergey V, Kudryavtseva, Lyudmila A, Latypov, Shamil K, Reznik, Vladimir S, Konovalov, Alexander I

“…New amphiphilic pyrimidinic macrocycles (APMs) with two (APM-1) and three (APM-2) decyl tails have been synthesized by quaternization of the bridged N. Complex…”
Get full text

Synthesis and reactivity of acyclic and macrocyclic uracils bridged with five-membered heterocycles by Semenov, Vyacheslav E., Krylova, Evgeniya S., Galyametdinova, Irina V., Chernova, Alla V., Kharlamov, Sergey V., Latypov, Shamil K., Reznik, Vladimir S.

“…Replacement of terminal atoms of Br in 1,3-bis(bromopentyl)-5(6)-substituted uracils with 2-mercapto-5-methyl-1,3,4-thiadiazole,…”
Get full text

Preferential Protonation and Methylation Site of Thiopyrimidine Derivatives in Solution:  NMR Data by Kozlov, Artem V, Semenov, Vyacheslav E, Mikhailov, Anatoliy S, Aganov, Albert V, Smith, Michael B, Reznik, Vladimir S, Latypov, Shamil K

“…Protonation (alkylation) sites of several thiopyrimidine derivatives were directly determined by 1H−15N (1H−13C) heteronuclear single quantum…”
Get full text

Structure and dynamics of pyrimidine-based macrocycles in solution by Kozlov, Artem V., Semenov, Vyacheslav E., Mikhailov, Anatoliy S., Reznik, Vladimir S., Latypov, Shamil K.

“…The conformational structure of macrocycles obtained from two thiopyrimidine and uracil nucleic acids linked by polymethylene spacers is determined by the…”
Get full text

Synthesis and structure of pyrimidinophanes with a sulfur atom in the spacer by Nikolaev, Anton E., Semenov, Vyacheslav E., Lodochnikova, Olga A., Latypov, Shamil K., Reznik, Vladimir S.

“…The cyclization of 1,3-bis(ω-bromoalkyl)uracils with sodium sulfide led to pyrimidinophanes, containing one uracil unit and an S atom in the spacer,…”
Get full text

Supramolecular catalytic systems based on bolaform pyrimidinic surfactants: the counterion effect by Zakharova, Lucia Ya, Syakaev, Victor V., Voronin, Mikhail A., Semenov, Vyacheslav E., Valeeva, Farida G., Giniyatullin, Rashit Kh, Latypov, Shamil K., Reznik, Vladimir S., Konovalov, Alexander I.

“…The catalytic effect of new amphiphilic pyrimidinic compounds with two ammonium head groups and different kinds of counterions, inorganic bromide anions and…”
Get full text

Intramolecular interactions in acyclic and macrocyclic compounds containing nucleotide bases by Semenov, Vaycheslav E, Akamsin, Valentin D, Reznik, Vladimir S, Chernova, Alla V, Dorozhkina, Galina M, Efremov, Yurij Ya, Nafikova, Adilay A

“…Acyclic and cyclic counterparts containing thymine and two 3,6-dimethyluracil fragments bridged by methylene chains have been prepared and studied by UV and…”
Get full text

Genotoxicity study of a new tetraalkylammonium derivative of 6-methyluracil (agent No. 547) by Karamova, Nazira S, Ivanchenko, Olga B, Ilinskaya, Olga N, Zobov, Vladimir V, Reznik, Vladimir S

“…Agent No. 547 (1,3-bis[omega-(diethyl-ortho-nitrobenzylammonio)-pentyl]-6-methyluracil dibromide), a newly synthesized inhibitor of mammalian-specific…”
Get full text

Unusual Reaction of Macrocyclic Uracils with Paraformaldehyde by Semenov, Vyacheslav E., Giniyatullin, Rashit Kh, Mikhailov, Anatoly S., Nikolaev, Anton E., Kharlamov, Sergey V., Latypov, Shamil K., Reznik, Vladimir S.

“…The ability of simple uracils to afford bis(uracil‐5‐yl)methanes upon reaction with paraformaldehyde is well documented. This reaction has been used in the…”
Get full text

Macrocyclic 5-bromouracil derivatives: synthesis and transformation of a uracil ring by Nikolaev, Anton E., Semenov, Vyacheslav E., Sharafutdinova, Dilyara R., Efremov, Yurii Ya, Reznik, Vladimir S.

“…Cyclization of 1,3-bis(ω-bromoalkyl)-5-bromouracil with p-methoxybenzylamine or sodium sulfide led to a series of pyrimidinophanes containing heteroatoms in…”
Get full text

Triuracils - 1,3-Bis[ω-(N-methyluracil-1-yl)alkyl]thymines and Their 5,5′-Cyclic Counterparts by Semenov, Vyacheslav E., Galiullina, Leisan F., Lodochnikova, Olga A., Kataeva, Olga N., Gubaidullin, Aidar T., Chernova, Alla V., Efremov, Yurij Y., Latypov, Shamil K., Reznik, Vladimir S.

“…A series of acyclic compounds with two 3,6‐dimethyluracil or 3‐methyluracil units attached to a a thymine or isocyanurate fragment by polymethylene or xylylene…”
Get full text

Preferential Protonation and Methylation Site of Thiopyrimidine Derivatives in Solution: NMR Data by Kozlov, Artem V, Semenov, Vyacheslav E, Mikhailov, Anatoliy S, Aganov, Albert V, Smith, Michael B, Reznik, Vladimir S, Latypov, Shamil K

“…Protonation (alkylation) sites of several thiopyrimidine derivatives were directly determined by super(1)H- super(15)N ( super(1)H- super(13)C) heteronuclear…”
Get full text