Search Results - "Reznik, Nava"

Intestinal Gel-Forming Mucins Polymerize by Disulfide-Mediated Dimerization of D3 Domains by Javitt, Gabriel, Calvo, María Luisa Gómez, Albert, Lis, Reznik, Nava, Ilani, Tal, Diskin, Ron, Fass, Deborah

“…The mucin 2 glycoprotein assembles into a complex hydrogel that protects intestinal epithelia and houses the gut microbiome. A major step in mucin 2 assembly…”
Get full text

The disulfide catalyst QSOX1 maintains the colon mucosal barrier by regulating Golgi glycosyltransferases by Ilani, Tal, Reznik, Nava, Yeshaya, Noa, Feldman, Tal, Vilela, Patrick, Lansky, Zipora, Javitt, Gabriel, Shemesh, Michal, Brenner, Ori, Elkis, Yoav, Varsano, Neta, Jaramillo, Ana M, Evans, Christopher M, Fass, Deborah

“…Mucus is made of enormous mucin glycoproteins that polymerize by disulfide crosslinking in the Golgi apparatus. QSOX1 is a catalyst of disulfide bond formation…”
Get full text

Disulfide bond formation and redox regulation in the Golgi apparatus by Reznik, Nava, Fass, Deborah

“…Formation of disulfide bonds in secreted and cell‐surface proteins involves numerous enzymes and chaperones abundant in the endoplasmic reticulum (ER), the…”
Get full text

Abstract 1859 Mucin glycoproteins manage copper at mucosal surfaces by Fass, Deborah, Reznik, Nava, Chacon, Kelly, Franz, Katherine

Get full text

Conformational switches and redox properties of the colon cancer‐associated human lectin ZG16 by Javitt, Gabriel, Kinzel, Alisa, Reznik, Nava, Fass, Deborah

“…Zymogen granule membrane protein 16 (ZG16) is produced in organs that secrete large quantities of enzymes and other proteins into the digestive tract. ZG16…”
Get full text

Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening by Resnick, Efrat, Bradley, Anthony, Gan, Jinrui, Douangamath, Alice, Krojer, Tobias, Sethi, Ritika, Geurink, Paul P, Aimon, Anthony, Amitai, Gabriel, Bellini, Dom, Bennett, James, Fairhead, Michael, Fedorov, Oleg, Gabizon, Ronen, Gan, Jin, Guo, Jingxu, Plotnikov, Alexander, Reznik, Nava, Ruda, Gian Filippo, Díaz-Sáez, Laura, Straub, Verena M, Szommer, Tamas, Velupillai, Srikannathasan, Zaidman, Daniel, Zhang, Yanling, Coker, Alun R, Dowson, Christopher G, Barr, Haim M, Wang, Chu, Huber, Kilian V.M, Brennan, Paul E, Ovaa, Huib, von Delft, Frank, London, Nir

“…Covalent probes can display unmatched potency, selectivity, and duration of action; however, their discovery is challenging. In principle, fragments that can…”
Get full text

Intestinal mucin is a chaperone of multivalent copper by Reznik, Nava, Gallo, Annastassia D., Rush, Katherine W., Javitt, Gabriel, Fridmann-Sirkis, Yael, Ilani, Tal, Nairner, Noa A., Fishilevich, Simon, Gokhman, David, Chacón, Kelly N., Franz, Katherine J., Fass, Deborah

“…Mucus protects the epithelial cells of the digestive and respiratory tracts from pathogens and other hazards. Progress in determining the molecular mechanisms…”
Get full text

Phenotypic Screen Identifies JAK2 as a Major Regulator of FAT10 Expression by Reznik, Nava, Kozer, Noga, Eisenberg-Lerner, Avital, Barr, Haim, Merbl, Yifat, London, Nir

“…FAT10 is a ubiquitin-like protein suggested to target proteins for proteasomal degradation. It is highly upregulated upon pro-inflammatory cytokines, namely,…”
Get full text