Scolicidal effect of Allium sativum flowers on hydatid cyst protoscolices
he s Because there is no effective and safe drug therapy for hydatid cyst, finding of some new agents especially from herbal origin with a desired scolicidal effect attracts great attention for treatment and pre-surgical use to prevent the hydatid cyst recurrence. In this study, the scolicidal effec...
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| Published in: | European review for medical and pharmacological sciences Vol. 20; no. 1; p. 129 |
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| Main Authors: | , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Italy
2016
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| Subjects: | |
| Online Access: | Get more information |
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| Summary: | he s
Because there is no effective and safe drug therapy for hydatid cyst, finding of some new agents especially from herbal origin with a desired scolicidal effect attracts great attention for treatment and pre-surgical use to prevent the hydatid cyst recurrence. In this study, the scolicidal effect of ultrasonic methanol extract of Garlic (Allium sativum) flower is investigated.
Protoscolices were collected aseptically from sheep livers containing hydatid cyst and were exposed to different concentrations of extract for various exposure times. The viability of protoscolices was confirmed by 0.1% Eosin staining.
The scolicidal activity of extract at a concentration of 50 mg ml-1 was 59, 76, 81 and 86% after 10, 30, 60, and 180 min of exposure respectively. The scolicidal effect at 100 mg ml-1 was 67, 78, 85 and 98% after various exposure times, respectively. The results of this study showed that the ultrasonic extract has high scolicidal activity and might be used as a natural scolicidal agent.
Garlic flower extracts is a potent protoscolicid and might be used in hydatid cyst treatment and pre-surgery to prevent secondary cyst recurrence. |
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| ISSN: | 2284-0729 |