Search Results - "Reyor, Laura"

Broadly directed virus-specific CD4+ T cell responses are primed during acute hepatitis C infection, but rapidly disappear from human blood with viral persistence by Schulze Zur Wiesch, Julian, Ciuffreda, Donatella, Lewis-Ximenez, Lia, Kasprowicz, Victoria, Nolan, Brian E, Streeck, Hendrik, Aneja, Jasneet, Reyor, Laura L, Allen, Todd M, Lohse, Ansgar W, McGovern, Barbara, Chung, Raymond T, Kwok, William W, Kim, Arthur Y, Lauer, Georg M

“…Vigorous proliferative CD4(+) T cell responses are the hallmark of spontaneous clearance of acute hepatitis C virus (HCV) infection, whereas comparable…”
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Reduced frequencies of NKp30+NKp46+, CD161+, and NKG2D+ NK cells in acute HCV infection may predict viral clearance by Alter, Galit, Jost, Stephanie, Rihn, Suzannah, Reyor, Laura L, Nolan, Brian E, Ghebremichael, Musie, Bosch, Ronald, Altfeld, Marcus, Lauer, Georg M

“…Background & Aims While the majority of HCV-infected patients progress to chronic hepatitis, a small fraction of individuals are able to clear the virus…”
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Spontaneous control of HCV is associated with expression of HLA-B 57 and preservation of targeted epitopes by Kim, Arthur Y, Kuntzen, Thomas, Timm, Joerg, Nolan, Brian E, Baca, Melanie A, Reyor, Laura L, Berical, Andrew C, Feller, Andrea J, Johnson, Kristin L, Schulze zur Wiesch, Julian, Robbins, Gregory K, Chung, Raymond T, Walker, Bruce D, Carrington, Mary, Allen, Todd M, Lauer, Georg M

“…HLA class I alleles are linked to spontaneous control of hepatitis C virus (HCV) and human immunodeficiency virus-1, but for HCV the roles of particular…”
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High Level of PD-1 Expression on Hepatitis C Virus (HCV)-Specific CD8+ and CD4+ T Cells during Acute HCV Infection, Irrespective of Clinical Outcome by KASPROWICZ, Victoria, SCHULZE ZUR WIESCH, Julian, KWOK, William W, MCGOVERN, Barbara G, FREEMAN, Gordon, CHUNG, Raymond T, KLENERMAN, Paul, LEWIS-XIMENEZ, Lia, WALKER, Bruce D, ALLEN, Todd M, KIM, Arthur Y, LAUER, Georg M, KUNTZEN, Thomas, NOLAN, Brian E, LONGWORTH, Steven, BERICAL, Andrew, BLUM, Jenna, MCMAHON, Cory, REYOR, Laura L, ELIAS, Nahel

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Improving the Diagnosis of Acute Hepatitis C Virus Infection with Expanded Viral Load Criteria by McGovern, Barbara H., Birch, Christopher E., Bowen, Melinda J., Reyor, Laura L., Nagami, Ellen H., Chung, Raymond T., Kim, Arthur Y.

“…Background.The diagnosis of acute hepatitis C virus (HCV) infection is imprecise because antibody testing does not differentiate between acute and chronic…”
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Spontaneous Control of HCV Is Associated With Expression of HLA-B57 and Preservation of Targeted Epitopes by Kim, Arthur Y, Kuntzen, Thomas, Timm, Joerg, Nolan, Brian E, Baca, Melanie A, Reyor, Laura L, Berical, Andrew C, Feller, Andrea J, Johnson, Kristin L, Wiesch, Julian Schulze Zur, Robbins, Gregory K, Chung, Raymond T, Walker, Bruce D, Carrington, Mary, Allen, Todd M, Lauer, Georg M

“…Background & Aims HLA class I alleles are linked to spontaneous control of hepatitis C virus (HCV) and human immunodeficiency virus−1, but for HCV the roles of…”
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CD8 epitope escape and reversion in acute HCV infection by Timm, Joerg, Lauer, Georg M, Kavanagh, Daniel G, Sheridan, Isabelle, Kim, Arthur Y, Lucas, Michaela, Pillay, Thillagavathie, Ouchi, Kei, Reyor, Laura L, Schulze zur Wiesch, Julian, Gandhi, Rajesh T, Chung, Raymond T, Bhardwaj, Nina, Klenerman, Paul, Walker, Bruce D, Allen, Todd M

“…In the setting of acute hepatitis C virus (HCV) infection, robust HCV-specific CD8+ cytotoxic T lymphocyte (CTL) responses are associated with initial control…”
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Human leukocyte antigen B27 selects for rare escape mutations that significantly impair hepatitis C virus replication and require compensatory mutations by Neumann‐Haefelin, Christoph, Oniangue‐Ndza, Cesar, Kuntzen, Thomas, Schmidt, Julia, Nitschke, Katja, Sidney, John, Caillet‐Saguy, Célia, Binder, Marco, Kersting, Nadine, Kemper, Michael W., Power, Karen A., Ingber, Susan, Reyor, Laura L., Hills‐Evans, Kelsey, Kim, Arthur Y., Lauer, Georg M., Lohmann, Volker, Sette, Alessandro, Henn, Matthew R., Bressanelli, Stéphane, Thimme, Robert, Allen, Todd M.

“…Human leukocyte antigen B27 is associated with spontaneous viral clearance in hepatitis C virus (HCV) infection. Viral escape within the immunodominant,…”
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Selective Escape from CD8+ T-Cell Responses Represents a Major Driving Force of Human Immunodeficiency Virus Type 1 (HIV-1) Sequence Diversity and Reveals Constraints on HIV-1 Evolution by ALLEN, Todd M, ALTFELD, Marcus, KAUFMANN, Daniel E, LAHAIE, Matthew P, REYOR, Laura, TANZI, Giancarlo, JOHNSTON, Mary N, BRANDER, Christian, DRAENERT, Rika, ROCKSTROH, Jurgen K, JESSEN, Heiko, ROSENBERG, Eric S, GEER, Shaun C, MALLAL, Simon A, WALKER, Bruce D, KALIFE, Elizabeth T, MOORE, Corey, O'SULLIVAN, Kristin M, DESOUZA, Ivna, FEENEY, Margaret E, ELDRIDGE, Robert L, MAIER, Erica L

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Human leukocyte antigen–associated sequence polymorphisms in hepatitis C virus reveal reproducible immune responses and constraints on viral evolution by Timm, Joerg, Li, Bin, Daniels, Marcus G., Bhattacharya, Tanmoy, Reyor, Laura L., Allgaier, Rachel, Kuntzen, Thomas, Fischer, Will, Nolan, Brian E., Duncan, Jared, Schulze zur Wiesch, Julian, Kim, Arthur Y., Frahm, Nicole, Brander, Christian, Chung, Raymond T., Lauer, Georg M., Korber, Bette T., Allen, Todd M.

“…CD8+ T cell responses play a key role in governing the outcome of hepatitis C virus (HCV) infection, and viral evolution enabling escape from these responses…”
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Compensatory Mutations Restore the Replication Defects Caused by Cytotoxic T Lymphocyte Escape Mutations in Hepatitis C Virus Polymerase by ONIANGUE-NDZA, Cesar, KUNTZEN, Thomas, GLADDEN, Adrianne D, BLOOM, Allyson K, POWER, Karen A, THIMME, Robert, LAUER, Georg M, HENN, Matthew R, KIM, Arthur Y, ALLEN, Todd M, KEMPER, Michael, BERICAL, Andrew, WANG, Yaoyu E, NEUMANN-HAEFELIN, Christoph, KRISTIAN FOOTE, Peter, HILLS-EVANS, Kelsey, REYOR, Laura L, KANE, Katherine

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Transmission and Long-Term Stability of Compensated CD8 Escape Mutations by Schneidewind, Arne, Brumme, Zabrina L, Brumme, Chanson J, Power, Karen A, Reyor, Laura L, O'Sullivan, Kristin, Gladden, Adrianne, Hempel, Ursula, Kuntzen, Thomas, Wang, Yaoyu E, Oniangue-Ndza, Cesar, Jessen, Heiko, Markowitz, Martin, Rosenberg, Eric S, Sékaly, Rafick-Pierre, Kelleher, Anthony D, Walker, Bruce D, Allen, Todd M

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De Novo Generation of Escape Variant-Specific CD8+ T-Cell Responses following Cytotoxic T-Lymphocyte Escape in Chronic Human Immunodeficiency Virus Type 1 Infection by ALLEN, Todd M, YU, Xu G, ALTER, Galit, BROWN, Nancy V, JOHNSTON, Mary N, ROSENBERG, Eric S, MALLAL, Simon A, BRANDER, Christian, WALKER, Bruce D, ALTFELD, Marcus, KALIFE, Elizabeth T, REYOR, Laura L, LICHTERFELD, Mathias, JOHN, Mina, CHENG, Michael, ALLGAIER, Rachel L, MUI, Stanley, FRAHM, Nicole

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Rate of Sustained Virologic Response in Relation to Baseline Hepatitis C Virus (HCV) RNA Level and Rapid Virologic Clearance in Persons with Acute HCV Infection by McGovern, Barbara H., Nagami, Ellen H., Birch, Christopher E., Bowen, Melinda J., Reyor, Laura L., Chung, Raymond T., Kim, Arthur Y.

“…Treatment of acute hepatitis C virus (HCV) infection leads to a sustained virologic response (SVR) in the vast majority of patients, although the clinical…”
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Temporal Dynamics of a Predominant Protease Inhibitor–Resistance Mutation in a Treatment-Naive, Hepatitis C Virus–Infected Individual by Kim, Arthur Y., Timm, Joerg, Nolan, Brian E., Reyor, Laura L., Kane, Katherine, Berical, Andrew C., Zachary, Kimon C., Lauer, Georg M., Kuntzen, Thomas, Allen, Todd M.

“…The dramatic antiviral activities of drugs that specifically inhibit hepatitis C virus replication can be tempered by baseline mutations that confer…”
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The Majority of Currently Circulating Human Immunodeficiency Virus Type 1 Clade B Viruses Fail To Prime Cytotoxic T-Lymphocyte Responses against an Otherwise Immunodominant HLA-A2-Restricted Epitope: Implications for Vaccine Design by ALTFELD, Marcus, ALLEN, Todd M, PERKINS, Beth, ROBINSON, Loren K, SIDNEY, John, ALTER, Galit, LICHTERFELD, Mathias, SETTE, Alessandro, ROSENBERG, Eric S, GOULDER, Philip J. R, BRANDER, Christian, WALKER, Bruce D, KALIFE, Elizabeth T, FRAHM, Nicole, ADDO, Marylyn M, MOTHE, Bianca R, RATHOD, Almas, REYOR, Laura L, HARLOW, Jason, YU, Xu G

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Naturally occurring dominant resistance mutations to hepatitis C virus protease and polymerase inhibitors in treatment‐naïve patients by Kuntzen, Thomas, Timm, Joerg, Berical, Andrew, Lennon, Niall, Berlin, Aaron M., Young, Sarah K., Lee, Bongshin, Heckerman, David, Carlson, Jonathan, Reyor, Laura L., Kleyman, Marianna, McMahon, Cory M., Birch, Christopher, Schulze zur Wiesch, Julian, Ledlie, Timothy, Koehrsen, Michael, Kodira, Chinnappa, Roberts, Andrew D., Lauer, Georg M., Rosen, Hugo R., Bihl, Florian, Cerny, Andreas, Spengler, Ulrich, Liu, Zhimin, Kim, Arthur Y., Xing, Yanming, Schneidewind, Arne, Madey, Margaret A., Fleckenstein, Jaquelyn F., Park, Vicki M., Galagan, James E., Nusbaum, Chad, Walker, Bruce D., Lake‐Bakaar, Gerond V., Daar, Eric S., Jacobson, Ira M., Gomperts, Edward D., Edlin, Brian R., Donfield, Sharyne M., Chung, Raymond T., Talal, Andrew H., Marion, Tony, Birren, Bruce W., Henn, Matthew R., Allen, Todd M.

“…Resistance mutations to hepatitis C virus (HCV) nonstructural protein 3 (NS3) protease inhibitors in <1% of the viral quasispecies may still allow >1000‐fold…”
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HLA-B27 Selects for Rare Escape Mutations that Significantly Impair Hepatitis C Virus Replication and Require Compensatory Mutations by Neumann-Haefelin, Christoph, Oniangue-Ndza, Cesar, Kuntzen, Thomas, Schmidt, Julia, Nitschke, Katja, Sidney, John, Caillet-Saguy, Célia, Binder, Marco, Kersting, Nadine, Kemper, Michael W., Power, Karen A., Ingber, Susan, Reyor, Laura L., Hills-Evans, Kelsey, Kim, Arthur Y., Lauer, Georg M., Lohmann, Volker, Sette, Alessandro, Henn, Matthew R., Bressanelli, Stéphane, Thimme, Robert, Allen, Todd M.

“…HLA-B27 is associated with spontaneous viral clearance in hepatitis C virus (HCV) infection. Viral escape within the immunodominant HLA-B27 restricted…”
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Improving the Diagnosis of Acute Hepatitis C Infection using Expanded Viral Load Criteria by McGovern, Barbara H., Birch, Christopher E., Bowen, Melinda J., Reyor, Laura L., Nagami, Ellen H., Chung, Raymond T., Kim, Arthur Y.

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High rates of sustained virologic response in acute hepatitis C virus infection are associated with low levels of HCV RNA and rapid virologic clearance by McGovern, Barbara H., Nagami, Ellen H., Birch, Christopher E., Bowen, Melinda J., Reyor, Laura L., Chung, Raymond T., Kim, Arthur Y.

“…Treatment of acute hepatitis C virus (HCV) infection leads to a sustained virologic response (SVR) in the vast majority of patients, although the clinical…”
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