Search Results - "Reynolds, Thomas C"

A Phase 3, Randomized, Double-Blind Comparative Study of the Efficacy and Safety of Topical Recombinant Human Thrombin and Bovine Thrombin in Surgical Hemostasis by Chapman, William C., MD, FACS, Singla, Neil, MD, Genyk, Yuri, MD, FACS, McNeil, James W., MD, FACS, Renkens, Kenneth L., MD, FACS, Reynolds, Thomas C., MD, PhD, Murphy, Aileen, MPH, Weaver, Fred A., MD, FACS

“…Background Plasma-derived bovine thrombin is used as a topical agent to improve surgical hemostasis, but development of antibodies to bovine hemostatic…”
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Phase I trial of intranasal and endobronchial administration of a recombinant adeno-associated virus serotype 2 (rAAV2)-CFTR vector in adult cystic fibrosis patients: a two-part clinical study by Flotte, Terence R, Zeitlin, Pamela L, Reynolds, Thomas C, Heald, Alison E, Pedersen, Patty, Beck, Suzanne, Conrad, Carol K, Brass-Ernst, Lois, Humphries, Margaret, Sullivan, Kevin, Wetzel, Randall, Taylor, George, Carter, Barrie J, Guggino, William B

“…Recombinant adeno-associated serotype 2-based vectors (rAAV2) possess a number of theoretical advantages for cystic fibrosis (CF) gene therapy because they…”
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Phase I Trial of Intratumoral Liposome E1A Gene Therapy in Patients with Recurrent Breast and Head and Neck Cancer by YOO, George H, HUNG, Mien-Chie, LOPEZ-BERESTEIN, Gabriel, LAFOLLETTE, Susan, ENSLEY, John F, CAREY, Mary, BATSON, Eric, REYNOLDS, Thomas C, MURRAY, James L

“…Purpose : We conducted a Phase 1 study to determine the maximal tolerated dose and maximum biologically active dose of the E1A gene delivered by intratumoral…”
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Genetic Ancestry Correlates with Somatic Differences in a Real-World Clinical Cancer Sequencing Cohort by Arora, Kanika, Tran, Thinh N, Kemel, Yelena, Mehine, Miika, Liu, Ying L, Nandakumar, Subhiksha, Smith, Shaleigh A, Brannon, A Rose, Ostrovnaya, Irina, Stopsack, Konrad H, Razavi, Pedram, Safonov, Anton, Rizvi, Hira A, Hellmann, Matthew D, Vijai, Joseph, Reynolds, Thomas C, Fagin, James A, Carrot-Zhang, Jian, Offit, Kenneth, Solit, David B, Ladanyi, Marc, Schultz, Nikolaus, Zehir, Ahmet, Brown, Carol L, Stadler, Zsofia K, Chakravarty, Debyani, Bandlamudi, Chaitanya, Berger, Michael F

“…Accurate ancestry inference is critical for identifying genetic contributors of cancer disparities among populations. Although methods to infer genetic…”
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Safety and pharmacokinetics of recombinant factor XIII in healthy volunteers: a randomized, placebo-controlled, double-blind, multi-dose study by Visich, Jennifer E, Zuckerman, Linda A, Butine, Michael D, Gunewardena, Kulasiri A, Wild, Richard, Morton, Kirsten M, Reynolds, Thomas C

“…Factor XIII (FXIII) is a plasma transglutaminase that covalently cross-links fibrin proteins to one another and to other proteins, increasing the mechanical…”
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A phase II, double-blind, randomized, placebo-controlled clinical trial of tgAAVCF using maxillary sinus delivery in patients with cystic fibrosis with antrostomies by Wagner, John A, Nepomuceno, Ilynn B, Messner, Anna H, Moran, Mary Lynn, Batson, Eric P, Dimiceli, Sue, Brown, Byron W, Desch, Julie K, Norbash, Alexander M, Conrad, Carol K, Guggino, William B, Flotte, Terence R, Wine, Jeffrey J, Carter, Barrie J, Reynolds, Thomas C, Moss, Richard B, Gardner, Phyllis

“…tgAAVCF, an adeno-associated cystic fibrosis transmembrane conductance regulator (CFTR) viral vector/gene construct, was administered to 23 patients in a Phase…”
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T-cell mediated rejection of gene-modified HIV-specific cytotoxic T lymphocytes in HIV-infected patients by Riddell, Stanley R, Elliott, Mark, Lewinsohn, Deborah A, Gilbert, Mark J, Wilson, Linda, Manley, Sara A, Lupton, Stephen D, Overell, Robert W, Reynolds, Thomas C, Corey, Lawrence, Greenberg, Philip D

“…The introduction and expression of genes in somatic cells is an innovative therapy for correcting genetic deficiency diseases and augmenting immune function. A…”
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Repeated Delivery of Adeno-Associated Virus Vectors to the Rabbit Airway by Beck, S E, Jones, L A, Chesnut, K, Walsh, S M, Reynolds, T C, Carter, B J, Askin, F B, Flotte, T R, Guggino, W B

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Protecting the privacy of third-party information: Recommendations for social and behavioral health researchers by Lounsbury, David W., Reynolds, Thomas C., Rapkin, Bruce D., Robson, Mark E., Ostroff, Jamie

“…In psychosocial and health-behavioral research, we often request that research participants provide information on significant individuals in their lives,…”
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How Adjunct Faculty Understand and Apply Learner‐Centered Pedagogy by Reynolds, Thomas C

“…This study examined how adjunct faculty understand and apply learner-centered pedagogy and the institutional factors that impact their capacity to learn and…”
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Abstract 2182: Ancestry inference and population-specific disparities in a real-world clinical sequencing cohort by Arora, Kanika, Tran, Thinh N., Kemel, Yelena M., Mehine, Miika, Liu, Ying, Smith, Shaleigh A., Nandakumar, Subhiksha, Ostrovnaya, Irina, Reynolds, Thomas C., Offit, Kenneth, Solit, David, Ladanyi, Marc, Schultz, Nikolaus, Zehir, Ahmet, Brown, Carol L., Chakravarty, Debyani, Stadler, Zsofia K., Bandlamudi, Chaitanya, Berger, Michael F.

“…Abstract Accurate ancestry inference is crucial for identifying genetic determinants of cancer disparities among specific populations. While methods to infer…”
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Integration of murine leukemia virus DNA depends on mitosis by Roe, T., Reynolds, T.C., Yu, G., Brown, P.O.

“…In synchronized rat or mouse cells infected with Moloney murine leukemia virus (MLV), integration of viral DNA and production of viral proteins occur only…”
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TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms by Ellisen, L W, Bird, J, West, D C, Soreng, A L, Reynolds, T C, Smith, S D, Sklar, J

“…Previously we described joining of DNA in the beta T cell receptor gene to DNA of an uncharacterized locus in a t(7;9)(q34;q34.3) chromosomal translocation…”
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In vivo model of adeno-associated virus vector persistence and rescue by Afione, S A, Conrad, C K, Kearns, W G, Chunduru, S, Adams, R, Reynolds, T C, Guggino, W B, Cutting, G R, Carter, B J, Flotte, T R

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Identification and elimination of replication-competent adeno-associated virus (AAV) that can arise by nonhomologous recombination during AAV vector production by Allen, J M, Debelak, D J, Reynolds, T C, Miller, A D

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A high-throughput hybridization method for titer determination of viruses and gene therapy vectors by Morrey Atkinson, E., Debelak, Daryn J., Hart, Lori A., Reynolds, Thomas C.

“…One of the challenges facing researchers working with viruses and gene therapy vectors is the need to rapidly assay for infectious virus. Current methods used…”
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Analysis of DNA surrounding the breakpoints of chromosomal translocations involving the beta T cell receptor gene in human lymphoblastic neoplasms by Reynolds, T C, Smith, S D, Sklar, J

“…DNA containing breakpoints of two different t(7;9) chromosomal translocations was cloned from the T lymphoblastic tumor cell lines SUP-T1 and SUP-T3. Sequence…”
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Micrococcal nuclease digestion study of spermidine-condensed DNA by Marx, K A, Reynolds, T C

“…Spermidine-condensed lambda DNA tertiary structures have been studied by micrococcal nuclease digestion. Broad but discrete DNA bands were observed in gel…”
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Spermidine-Condensed φ X174 DNA Cleavage by Micrococcal Nuclease: Torus Cleavage Model and Evidence for Unidirectional Circumferential DNA Wrapping by Marx, Kenneth A., Reynolds, Thomas C.

“…Spermidine-condensed φ X174 replicative form (RF) II DNA was digested with micrococcal nuclease to yield seven identifiable DNA bands forming an arithmetic…”
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Ion competition and micrococcal nuclease digestion studies of spermidine-condensed calf thymus DNA. Evidence for torus organization by circumferential DNA wrapping by Marx, K A, Reynolds, T C

“…Spermidine-condensed calf thymus DNA structures have been studied by ion competition using a sedimentation assay and by micrococcal nuclease digestion…”
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