Search Results - "Reynolds, Jennifer M"

In Vivo Evidence for the Specificity of Plasmodium falciparum Phosphoethanolamine Methyltransferase and Its Coupling to the Kennedy Pathway by Pessi, Gabriella, Choi, Jae-Yeon, Reynolds, Jennifer M., Voelker, Dennis R., Mamoun, Choukri Ben

“…Unlike humans and yeast, Plasmodium falciparum, the agent of the most severe form of human malaria, utilizes host serine as a precursor for the synthesis of…”
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A Phase I, dose-finding study in patients with advanced solid malignancies of the oral γ-secretase inhibitor PF-03084014 by Messersmith, Wells A, Shapiro, Geoffrey I, Cleary, James M, Jimeno, Antonio, Dasari, Arvind, Huang, Bo, Shaik, M Naveed, Cesari, Rossano, Zheng, Xianxian, Reynolds, Jennifer M, English, Patricia A, McLachlan, Karen R, Kern, Kenneth A, LoRusso, Patricia M

“…To estimate the maximum tolerated dose (MTD) for continuous oral administration of the γ-secretase inhibitor PF-03084014, determine the recommended phase II…”
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Localization of the Phosphoethanolamine Methyltransferase of the Human Malaria Parasite Plasmodium falciparum to the Golgi Apparatus by Witola, William H., Pessi, Gabriella, El Bissati, Kamal, Reynolds, Jennifer M., Mamoun, Choukri Ben

“…Phosphatidylcholine is the most abundant phospholipid in the membranes of Plasmodium falciparum, the agent of severe human malaria. The synthesis of this…”
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Sequence analysis of the IL28A/IL28B inverted gene duplication that contains polymorphisms associated with treatment response in hepatitis C patients by Reynolds, Jennifer M, Paciga, Sara A, Sanders, Frances A, Hyde, Craig L, Loomis, A Katrina, Johnston, Geoffrey I

“…Several SNPs located in or around the IL28B gene are associated with response of patients infected with Hepatitis C virus to treatment with pegylated…”
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Frequency and function of CETP variants among individuals of Asian ancestry by Thompson, John F, Reynolds, Jennifer M, Williams, Suzanne P, Wood, Linda S, Paciga, Sara A, Lloyd, David B

“…Abstract Genetic variation in CETP (cholesteryl ester transfer protein) has been clearly associated with HDL cholesterol levels but its association with…”
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Biochemical and Genetic Analysis of the Phosphoethanolamine Methyltransferase of the Human Malaria Parasite Plasmodium falciparum by Reynolds, Jennifer M., Takebe, Sachiko, Choi, Jae-Yeon, El Bissati, Kamal, Witola, William H., Bobenchik, April M., Hoch, Jeffrey C., Voelker, Dennis R., Mamoun, Choukri Ben

“…The PfPMT enzyme of Plasmodium falciparum, the agent of severe human malaria, is a member of a large family of known and predicted phosphoethanolamine…”
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Crystal Structures of Cholesteryl Ester Transfer Protein in Complex with Inhibitors by Liu, Shenping, Mistry, Anil, Reynolds, Jennifer M., Lloyd, David B., Griffor, Matthew C., Perry, David A., Ruggeri, Roger B., Clark, Ronald W., Qiu, Xiayang

“…Human plasma cholesteryl ester transfer protein (CETP) transports cholesteryl ester from the antiatherogenic high-density lipoproteins (HDL) to the…”
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Association of torsades de pointes with novel and known single nucleotide polymorphisms in long QT syndrome genes by Mank-Seymour, Amy R., Richmond, Jodi L., Wood, Linda S., Reynolds, Jennifer M., Fan, Yu-Ti, Warnes, Gregory R., Milos, Patrice M., Thompson, John F.

“…Reduction of drug-induced adverse events may be achievable through a better understanding of the underlying causes of such events. Identifying phenotypes and…”
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Novel variants in human and monkey CETP by Lloyd, David B., Reynolds, Jennifer M., Cronan, Melissa T., Williams, Suzanne P., Lira, Maruja E., Wood, Linda S., Knight, Delvin R., Thompson, John F.

“…Variation in CETP has been shown to play an important role in HDL-C levels and cardiovascular disease. To better characterize this variation, the promoter and…”
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Antimalarial activity of the anticancer and proteasome inhibitor bortezomib and its analog ZL3B by Reynolds, Jennifer M, El Bissati, Kamal, Brandenburg, Jens, Günzl, Arthur, Mamoun, Choukri Ben

“…The high rate of mortality due to malaria and the worldwide distribution of parasite resistance to the commonly used antimalarial drugs chloroquine and…”
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Abstract B119: Insulin-like growth factor 1 receptor mutants are inhibited by figitumumab (CP-751, 871) in vitro by Reynolds, Jennifer M., Lloyd, David B., Bentivegna, Steven C., Seymour, Albert B., Borzillo, Gary V., Gualberto, Antonio

“…Abstract To test the hypothesis that mutant insulin-like growth factor 1 receptor (IGF-1R) protein may differentially respond to inhibition by figitumumab…”
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Neuronal injury in the motor cortex after chronic stroke and lower limb motor impairment： a voxel- based lesion symptom mapping study by Reynolds, Alexandria M, Peters, Denise M, Vendemia, Jennifer M C, Smith, Lenwood P, Sweet, Raymond C, Baylis, Gordon C, Krotish, Debra, Fritz, Stacy L

“…Many studies have examined motor impairments using voxel-based lesion symptom mapping, but few are reported regarding the corresponding relationship between…”
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Antimalarial activity of the anticancer and proteasome inhibitor bortezomib and its analog ZL.sub.3 B by Reynolds, Jennifer M, El Bissati, Kamal, Brandenburg, Jens, Gunzl, Arthur, Mamoun, Choukri Ben

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Antimalarial activity of the anticancer and proteasome inhibitor bortezomib and its analog ZL sub(3)B by Reynolds, Jennifer M, El Bissati, Kamal, Brandenburg, Jens, Guenzl, Arthur, Mamoun, Choukri Ben

“…Background The high rate of mortality due to malaria and the worldwide distribution of parasite resistance to the commonly used antimalarial drugs chloroquine…”
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