Search Results - "Reynolds, G.K"

Development of a discrete element model with moving realistic geometry to simulate particle motion in a Mi-Pro granulator by Watson, N.J., Povey, M.J.W., Reynolds, G.K., Ding, Y., Xu, B.H.

“…•We present the methodology for a 3D DEM model with moving realistic geometry.•Details on the selection of critical model input parameters and validation…”
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Surface velocity measurement in a high shear mixer by Nilpawar, A.M., Reynolds, G.K., Salman, A.D., Hounslow, M.J.

“…Particle velocity measurement in high shear granulation systems has been an area of interest in recent years. This paper gives an insight into the systemic…”
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Successful Formulation Window for the design of pharmaceutical tablets with required mechanical properties by Polak, P, Sinka, I C, Reynolds, G K, Roberts, R J

“…Pharmaceutical tablet formulations combine the active ingredient with processing aids and functional components. This paper evaluates compressibility based…”
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Using AI/ML to predict blending performance and process sensitivity for Continuous Direct Compression (CDC) by Jones-Salkey, O., Windows-Yule, C.R.K., Ingram, A., Stahler, L., Nicusan, A.L., Clifford, S., Martin de Juan, L., Reynolds, G.K.

“…Utilising three artificial intelligence (AI)/machine learning (ML) tools, this study explores the prediction of fill level in inclined linear blenders at…”
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Application of Positron Emission Particle Tracking (PEPT) for the evaluation of powder behaviour in an incline linear blender for Continuous Direct Compression (CDC) by Jones-Salkey, O., Nicusan, A.L., Windows-Yule, C.R.K., Ingram, A., Werner, D., Clifford, S., Reynolds, G.K.

“…Positron Emission Particle Tracking (PEPT) is a non-invasive measurement technique which offers the ability to track the motion of individual particles with…”
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Methodology to estimate the break force of pharmaceutical tablets with curved faces under diametrical compression by Al-Sabbagh, M., Polak, P., Roberts, R.J., Reynolds, G.K., Sinka, I.C.

“…[Display omitted] This paper develops a methodology to estimate the break force of curved faced tablets under diametrical compression. Common excipients used…”
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A compartmental CFD‐PBM model of high shear wet granulation by Yu, Xi, Hounslow, Michael J., Reynolds, Gavin K., Rasmuson, Anders, Niklasson Björn, Ingela, Abrahamsson, Per J.

“…The conventional, geometrically lumped description of the physical processes inside a high shear granulator is not reliable for process design and scale‐up. In…”
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Acoustic emission monitoring from a lab scale high shear granulator—A novel approach by Watson, N.J., Povey, M.J.W., Reynolds, G.K., Xu, B.H., Ding, Y.

“…A new approach to the monitoring of granulation processes using passive acoustics together with precise control over the granulation process has highlighted…”
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Breakage in granulation: A review by Reynolds, G.K., Fu, J.S., Cheong, Y.S., Hounslow, M.J., Salman, A.D.

“…The study of breakage in granulation is important from a process and from a product quality perspective. Breakage is considered an important rate process in…”
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Kinetic models for granule nucleation by the immersion mechanism by Hounslow, M.J., Oullion, M., Reynolds, G.K.

“…Two families of mathematical models for the kinetics of granule nucleation are presented. The first assumes that the driving force is surface tension at the…”
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Product engineering for crystal size distribution by Hounslow, M. J., Reynolds, G. K.

“…Product engineering problems are considered that arise in the use of batch crystallization processes. Specifically forward and reverse process functions are…”
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Simulating the early stage of high-shear granulation using a two-dimensional Monte-Carlo approach by Oullion, M., Reynolds, G.K., Hounslow, M.J.

“…A two-dimensional (2-D) model of a granulation process is presented in this paper. It aims to simulate an entire granulation batch without the use of an…”
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Impact deformation and rebound of wet granules by Fu, J., Adams, M.J., Reynolds, G.K., Salman, A.D., Hounslow, M.J.

“…The impact behaviour of wet granules was studied by measuring their restitution coefficient and maximum contact area. A flat semi-infinite rigid target was…”
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Blade-Granule Bed Stress in a Cylindrical High-Shear Granulator: Variability Studies by Chan, E. L., Reynolds, G. K., Gururajan, B., Salman, A. D., Hounslow, M. J.

“…The behavior of dry, steady‐state granule beds in each identified flow regime, i.e., frictional, toroidal, and fluidized, in a vertical‐axis cylindrical…”
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Modelling fragment size distribution using two-parameter Weibull equation by Cheong, Y.S., Reynolds, G.K., Salman, A.D., Hounslow, M.J.

“…The fragment size distribution of glass spheres fractured under impact loading is modelled using a two-parameter Weibull distribution equation. The effects of…”
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Descriptive classification of the impact failure modes of spherical particles by Salman, A.D, Reynolds, G.K, Fu, J.S, Cheong, Y.S, Biggs, C.A, Adams, M.J, Gorham, D.A, Lukenics, J, Hounslow, M.J

“…Based on observations of single impact studies of spherical coherent and agglomerate particles made from a wide range of materials, a classification of failure…”
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Non-uniformity of binder distribution in high-shear granulation by Reynolds, G.K, Biggs, C.A, Salman, A.D, Hounslow, M.J

“…Further experimental investigation based on a microscopic, or single granule, scale has been conducted to investigate the uniformity of binder composition…”
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An experimental study of the variability in the properties and quality of wet granules by Fu, J.S., Cheong, Y.S., Reynolds, G.K., Adams, M.J., Salman, A.D., Hounslow, M.J.

“…For wet high-shear granulation, there can be a considerable variability in product quality in terms of the size, binder content, porosity, and appearance…”
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Characterisation of impeller driven and oscillatory mixing by spatial and temporal shear rate distributions by Chew, C.M., Ristic, R.I., Reynolds, G.K., Ooi, R.C.

“…Computational fluid dynamics (CFD) technique was used to model spatial and temporal behaviour of flow patterns in an impeller-driven stirred vessel (IDSV) and…”
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Particle Impact Breakage in Particulate Processing by Salman, Agba, Reynolds, Gavin, Hounslow, Michael

“…The study of particle breakage in particulate processing is presented at two principal scales. Single-particle impact results are shown to be useful in…”
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