Search Results - "Reynolds, David M."

Activin A Efficiently Specifies Definitive Endoderm from Human Embryonic Stem Cells Only When Phosphatidylinositol 3‐Kinase Signaling Is Suppressed by McLean, Amanda B., D'Amour, Kevin A., Jones, Karen L., Krishnamoorthy, Malini, Kulik, Michael J., Reynolds, David M., Sheppard, Alan M., Liu, Huiqing, Xu, Ying, Baetge, Emmanuel E., Dalton, Stephen

“…Human ESCs (hESCs) respond to signals that determine their pluripotency, proliferation, survival, and differentiation status. In this report, we demonstrate…”
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Human Pluripotent Stem Cell-Derived Multipotent Vascular Progenitors of the Mesothelium Lineage Have Utility in Tissue Engineering and Repair by Colunga, Thomas, Hayworth, Miranda, Kreß, Sebastian, Reynolds, David M., Chen, Luoman, Nazor, Kristopher L., Baur, Johannes, Singh, Amar M., Loring, Jeanne F., Metzger, Marco, Dalton, Stephen

“…In this report we describe a human pluripotent stem cell-derived vascular progenitor (MesoT) cell of the mesothelium lineage. MesoT cells are multipotent and…”
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Whole-Genome Sequencing and iPLEX MassARRAY Genotyping Map an EMS-Induced Mutation Affecting Cell Competition in Drosophila melanogaster by Lee, Chang-Hyun, Rimesso, Gerard, Reynolds, David M, Cai, Jinlu, Baker, Nicholas E

“…Cell competition, the conditional loss of viable genotypes only when surrounded by other cells, is a phenomenon observed in certain genetic mosaic conditions…”
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Somatic Inactivation of Pkd2 Results in Polycystic Kidney Disease by Wu, Guanqing, D'Agati, Vivette, Cai, Yiqiang, Markowitz, Glen, Park, Jong Hoon, Reynolds, David M, Maeda, Yoshiko, Le, Thanh C, Hou, Harry, Kucherlapati, Raju, Edelmann, Winfried, Somlo, Stefan

“…Germline mutations in PKD2 cause autosomal dominant polycystic kidney disease. We have introduced a mutant exon 1 in tandem with the wild-type exon 1 at the…”
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Comparative Diagnostic Performance of Estimated Fetal Weight and Isolated Abdominal Circumference for the Detection of Fetal Growth Restriction by Whitham, Megan D., Reynolds, David M., Urban, Amanda R., Ennen, Christopher S., Dudley, Donald J.

“…Objectives To describe the comparative incidence, detection of small‐for‐gestational age (SGA), and composite perinatal morbidity (CPM) associated with…”
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Identification of a Locus for Autosomal Dominant Polycystic Liver Disease, on Chromosome 19p13.2-13.1 by Reynolds, David M., Falk, Cathy T., Li, Airong, King, Bernard F., Kamath, Patrick S., Huston, John, Shub, Clarence, Iglesias, Diana M., Martin, Rodolfo S., Pirson, Yves, Torres, Vicente E., Somlo, Stefan

“…Polycystic liver disease (PCLD) is characterized by the growth of fluid-filled cysts of biliary epithelial origin in the liver. Although the disease is often…”
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Mosaic epigenetic dysregulation of ectodermal cells in autism spectrum disorder by Berko, Esther R, Suzuki, Masako, Beren, Faygel, Lemetre, Christophe, Alaimo, Christine M, Calder, R Brent, Ballaban-Gil, Karen, Gounder, Batya, Kampf, Kaylee, Kirschen, Jill, Maqbool, Shahina B, Momin, Zeineen, Reynolds, David M, Russo, Natalie, Shulman, Lisa, Stasiek, Edyta, Tozour, Jessica, Valicenti-McDermott, Maria, Wang, Shenglong, Abrahams, Brett S, Hargitai, Joseph, Inbar, Dov, Zhang, Zhengdong, Buxbaum, Joseph D, Molholm, Sophie, Foxe, John J, Marion, Robert W, Auton, Adam, Greally, John M

“…DNA mutational events are increasingly being identified in autism spectrum disorder (ASD), but the potential additional role of dysregulation of the epigenome…”
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Amnion as a surrogate tissue reporter of the effects of maternal preeclampsia on the fetus by Suzuki, Masako, Maekawa, Ryo, Patterson, Nicole E, Reynolds, David M, Calder, Brent R, Reznik, Sandra E, Heo, Hye J, Einstein, Francine Hughes, Greally, John M

“…Preeclampsia, traditionally characterized by high blood pressure and proteinuria, is a common pregnancy complication, which affects 2-8 % of all pregnancies…”
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Forkhead transcription factors, Fkh1p and Fkh2p, collaborate with Mcm1p to control transcription required for M-phase by Kumar, Raman, Reynolds, David M, Shevchenko, Andrej, Shevchenko, Anna, Goldstone, Sherilyn D, Dalton, Stephen

“…Background: The ‘CLB2 cluster’ in Saccharomyces cerevisiae consists of approximately 33 genes whose transcription peaks in late G2/early M phase of the cell…”
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PKD2, a Gene for Polycystic Kidney Disease That Encodes an Integral Membrane Protein by Mochizuki, Toshio, Wu, Guanqing, Hayashi, Tomohito, Xenophontos, Stavroulla L., Veldhuisen, Barbera, Saris, Jasper J., Reynolds, David M., Cai, Yiqiang, Gabow, Patricia A., Pierides, Alkis, Kimberling, William J., Breuning, Martijn H., Deltas, C. Constantinou, Dorien J. M. Peters, Somlo, Stefan

“…A second gene for autosomal dominant polycystic kidney disease was identified by positional cloning. Nonsense mutations in this gene (PKD2) segregated with the…”
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Aberrant splicing in the PKD2 gene as a cause of polycystic kidney disease by REYNOLDS, D. M, HAYASHI, T, FOSSDAL, R, COTO, E, GUANQINGWU, BREUNING, M. H, GERMINO, G. G, PETERS, D. J. M, SOMLO, S, YIQIANG CAI, VELDHUISEN, B, WATNICK, T. J, LENS, X. M, MOCHIZUKI, T, QIAN, F, MAEDA, Y, LI LI

“…It is estimated that approximately 15% of families with autosomal dominant polycystic kidney disease (ADPKD) have mutations in PKD2. Identification of these…”
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Characterization of the Exon Structure of the Polycystic Kidney Disease 2 Gene (PKD2) by Hayashi, Tomohito, Mochizuki, Toshio, Reynolds, David M., Wu, Guanqing, Cai, Yiqiang, Somlo, Stefan

“…PKD2, the gene defective in the second form of autosomal dominant polycystic kidney disease (ADPKD), has been identified by positional cloning and found to…”
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Identification ofPKD2L,a HumanPKD2-Related Gene: Tissue-Specific Expression and Mapping to Chromosome 10q25 by Wu, Guanqing, Hayashi, Tomohito, Park, Jong-Hoon, Dixit, Mehul, Reynolds, David M., Li, Li, Maeda, Yoshiko, Cai, Yiqiang, Coca-Prados, Miguel, Somlo, Stefan

“…Mutations inPKD2cause autosomal dominant kidney disease (ADPKD). Polycystin-2, thePKD2gene product, is an integral membrane glycoprotein of unknown function…”
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Rapid screening of SNPs in metastatic colorectal cancer (mCRC) utilizing multiplex sequencing technology (Sequenom) by Maitra, Radhashree, Nayak, Jay B., Basu-Mallick, Atrayee, Sood, Arjun, Augustine, Titto A, Mariadason, John, Reynolds, David M, Goel, Sanjay

“…Abstract only 418 Background: Accurate and fast screening of mutations is essential for designing individualized therapy necessary and critical for efficient…”
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Mosaic Epigenetic Dysregulation of Ectodermal Cells in Autism Spectrum Disorder: e1004402 by Berko, Esther R, Suzuki, Masako, Beren, Faygel, Lemetre, Christophe, Alaimo, Christine M, Calder, R Brent, Ballaban-Gil, Karen, Gounder, Batya, Kampf, Kaylee, Kirschen, Jill, Maqbool, Shahina B, Momin, Zeineen, Reynolds, David M, Russo, Natalie, Shulman, Lisa, Stasiek, Edyta, Tozour, Jessica, Valicenti-McDermott, Maria, Wang, Shenglong, Abrahams, Brett S, Hargitai, Joseph, Inbar, Dov, Zhang, Zhengdong, Buxbaum, Joseph D, Molholm, Sophie, Foxe, John J, Marion, Robert W, Auton, Adam, Greally, John M

“…DNA mutational events are increasingly being identified in autism spectrum disorder (ASD), but the potential additional role of dysregulation of the epigenome…”
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Evidence for a third genetic locus for autosomal dominant polycystic kidney disease by Daoust, Martin C., Reynolds, David M., Bichet, Daniel G., Somlo, Stefan

“…Autosomal dominant polycystic kidney disease (ADPKD) is a genetically heterogeneous disease with loci on chromosomes 16p and 4q. It has a moderately high…”
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Identification of PKD2L, a human pkd2-related gene : Tissue-specific expression and mapping to chromosome 10q25 by GUANQING WU, HAYASHI, T, PARK, J.-H, DIXIT, M, REYNOLDS, D. M, LI LI, MAEDA, Y, YIQIANG CAI, COCA-PRADOS, M, SOMLO, S

“…Mutations in PKD2 cause autosomal dominant kidney disease (ADPKD). Polycystin-2, the PKD2 gene product, is an integral membrane glycoprotein of unknown…”
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Hydrodynamics-Based Gene Delivery of A Novel Interleukin-15 Plasmid Augments Natural Killer Cell Activities and Suppresses Lung Metastasis by Yazawa, Hiroshi, Ortaldo, John R, Back, Timothy C, Subleski, Jeffrey J, Seki, Naoko, Reynolds, David M, Winkler-Pickett, Robin T, Wiltrout, Robert H, Watanabe, Morihiro

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Novel stop and frameshifting mutations in the autosomal dominant polycystic kidney disease 2 (PKD2) gene by VIRIBAY, M, HAYASHI, T, SAN MILLAN, J. L, TELLERIA, D, MOCHIZUKI, T, REYNOLDS, D. M, ALONSO, R, LENS, X. M, MORENO, F, HARRIS, P. C, SOMLO, S

“…Autosomal dominant polycystic kidney disease (ADPKD) is one of the most frequent inherited disorders. The majority of cases are due to mutation of the PKD1…”
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Molecular cloning, cDNA sequence analysis, and chromosomal localization of mouse Pkd2 by WU, G, MOCHIZUKI, T, LE, T. C, CAI, Y, HAYASHI, T, REYNOLDS, D. M, SOMLO, S

“…The gene responsible for the second form of autosomal dominant polycystic kidney disease, PKD2, has recently been identified. We now describe the cloning,…”
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