Search Results - "Reynolds, C P"

Amino acid transporter SLC6A14 is a novel and effective drug target for pancreatic cancer by Coothankandaswamy, V, Cao, S, Xu, Y, Prasad, P D, Singh, P K, Reynolds, C P, Yang, S, Ogura, J, Ganapathy, V, Bhutia, Y D

“…Background and Purpose Pancreatic cancer is a solid tumour that is often fatal. Hence, there is an urgent need to identify new drug targets for this disease…”
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Evidence for an Age Cutoff Greater Than 365 Days for Neuroblastoma Risk Group Stratification in the Children's Oncology Group by LONDON, W. B, CASTLEBERRY, R. P, COHN, S. L, MATTHAY, K. K, LOOK, A. T, SEEGER, R. C, SHIMADA, H, THORNER, P, BRODEUR, G, MARIS, J. M, REYNOLDS, C. P

“…In the Children's Oncology Group, risk group assignment for neuroblastoma is critical for therapeutic decisions, and patients are stratified by International…”
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The glutathione synthesis inhibitor buthionine sulfoximine synergistically enhanced melphalan activity against preclinical models of multiple myeloma by Tagde, A, Singh, H, Kang, M H, Reynolds, C P

“…Melphalan (L-PAM) has been an integral part of multiple myeloma (MM) treatment as a conditioning regimen before stem cell transplant (SCT). After initial…”
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Increase of Ceramide and Induction of Mixed Apoptosis/Necrosis by N-(4-Hydroxyphenyl)- retinamide in Neuroblastoma Cell Lines by Maurer, Barry J., Metelitsa, Leonid S., Seeger, Robert C., Cabot, Myles C., Reynolds, C. Patrick

“…BACKGROUND: The synthetic retinoid N-(4-hydroxyphenyl)retinamide (4-HPR or fenretinide) is toxic to myeloid leukemia and cervical carcinoma cell lines,…”
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Treatment of High-Risk Neuroblastoma with Intensive Chemotherapy, Radiotherapy, Autologous Bone Marrow Transplantation, and 13-cis-Retinoic Acid by Matthay, Katherine K, Villablanca, Judith G, Seeger, Robert C, Stram, Daniel O, Harris, Richard E, Ramsay, Norma K, Swift, Patrick, Shimada, Hiroyuki, Black, C. Thomas, Brodeur, Garrett M, Gerbing, Robert B, Reynolds, C. Patrick

“…Neuroblastoma, the most common extracranial solid tumor of childhood, has a long-term survival rate of only 15 percent. 1 At diagnosis the defining…”
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N-(4-hydroxyphenyl)retinamide increases ceramide and is cytotoxic to acute lymphoblastic leukemia cell lines, but not to non-malignant lymphocytes by O'DONNELL, P. H, GUO, W-X, REYNOLDS, C. P, MAURER, B. J

“…The retinoid, N-(4-hydroxyphenyl)retinamide (4-HPR), mediates p53-independent cytotoxicity and can increase reactive oxygen species and ceramide in solid tumor…”
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Synergistic cytotoxicity of buthionine sulfoximine (BSO) and intensive melphalan (L-PAM) for neuroblastoma cell lines established at relapse after myeloablative therapy by ANDERSON, C. P, REYNOLDS, C. P

“…Patients with high-risk neuroblastoma (NB) initially respond to aggressive, alkylator-based therapy only to die from recurrent disease that is refractory to…”
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Drug resistance patterns of human neuroblastoma cell lines derived from patients at different phases of therapy by KESHELAVA, N, SEEGER, R. C, GROSHEN, S, REYNOLDS, C. P

“…To determine whether neuroblastomas acquire a sustained drug-resistant phenotype from exposure to chemotherapeutic agents given to patients in vivo, we studied…”
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Consolidation chemoradiotherapy and autologous bone marrow transplantation versus continued chemotherapy for metastatic neuroblastoma: a report of two concurrent Children's Cancer Group studies by Stram, D O, Matthay, K K, O'Leary, M, Reynolds, C P, Haase, G M, Atkinson, J B, Brodeur, G M, Seeger, R C

“…To compare event-free survival (EFS) for patients with stage IV neuroblastoma who were treated with induction chemotherapy followed by additional courses of…”
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Phase I trial of 13-cis-retinoic acid in children with neuroblastoma following bone marrow transplantation by Villablanca, J G, Khan, A A, Avramis, V I, Seeger, R C, Matthay, K K, Ramsay, N K, Reynolds, C P

“…Treatment of neuroblastoma cell lines with 13-cis-retinoic acid (cis-RA) can cause sustained inhibition of proliferation. Since cis-RA has demonstrated…”
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Is there a role for retinoids to treat minimal residual disease in neuroblastoma? by MATTHAY, K. K, REYNOLDS, C. P

“…A variety of pre-clinical and clinical data point toward high drug levels of retinoids being required to achieve optimal efficacy against neuroblastoma. The…”
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Determination of subcutaneous tumor size in athymic (nude) mice by TOMAYKO, M. M, REYNOLDS, C. P

“…The athymic (nude) mouse is a useful model for studying the biology and response to therapies of human tumors in vivo. A survey of recent literature revealed…”
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Allogeneic versus autologous purged bone marrow transplantation for neuroblastoma: a report from the Childrens Cancer Group by Matthay, K K, Seeger, R C, Reynolds, C P, Stram, D O, O'Leary, M C, Harris, R E, Selch, M, Atkinson, J B, Haase, G M, Ramsay, N K

“…We have compared the toxicity, relapse rate, and progression-free survival (PFS) of high-risk neuroblastoma patients receiving identical induction therapy and…”
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Patterns of relapse after autologous purged bone marrow transplantation for neuroblastoma: a Childrens Cancer Group pilot study by Matthay, K K, Atkinson, J B, Stram, D O, Selch, M, Reynolds, C P, Seeger, R C

“…The goal of this investigation was to determine if comparing sites of neuroblastoma at relapse after myeloablative chemoradiotherapy and purged autologous bone…”
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Cross-resistance of topoisomerase I and II inhibitors in neuroblastoma cell lines by KESHELAVA, N, GROSHEN, S, REYNOLDS, C. P

“…We have previously shown that neuroblastomal cell lines established from patients after intensive chemotherapy show sustained resistance to various drugs and…”
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High levels of p19/nm23 protein in neuroblastoma are associated with advanced stage disease and with N-myc gene amplification by HAILAT, N, KEIM, D. R, HANASH, S. M, MELHEM, R. F, XIAO-XIANG ZHU, ECKERSKORN, C, BRODEUR, G. M, REYNOLDS, C. P, SEEGER, R. C, LOTTSPEICH, F, STRAHLER, J. R

“…The gene encoding a novel protein designated nm23-H1, which was recently identified as identical to the A subunit of nucleotide diphosphate kinase from human…”
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Towards a conceptual framework for wildlife tourism by Reynolds, Paul C, Braithwaite, Dick

“…Tourism based on interactions with wildlife is increasing in popularity across the world. A conceptual framework is presented which begins to classify the…”
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Retinoid therapy of high-risk neuroblastoma by Reynolds, C.Patrick, Matthay, Katherine K., Villablanca, Judith G., Maurer, Barry J.

“…Retinoids are derivatives of vitamin A that include all trans-retinoic acid (ATRA), 13-cis-retinoic acid, (13-cis-RA), and fenretinide (4-HPR). High levels of…”
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Prognostic Value of Immunocytologic Detection of Bone Marrow Metastases in Neuroblastoma by Moss, Thomas J, Reynolds, C. Patrick, Sather, Harland N, Romansky, Stephen G, Hammond, G. Denman, Seeger, Robert C

“…NEUROBLASTOMA is the most common extra-cranial solid tumor in childhood. 1 In general, localized (Stage I or II), regional (Stage III), and metastatic (Stage…”
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Differentiating agents in pediatric malignancies: retinoids in neuroblastoma by Reynolds, C P

“…Retinoids are derivatives of vitamin A that include all- trans-retinoic acid (ATRA), 13-cis-retinoic acid, (13-cis-RA), and fenretinide (4-HPR). High levels of…”
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