Search Results - "Reyna, Denis E"

Co-targeting of BAX and BCL-XL proteins broadly overcomes resistance to apoptosis in cancer by Lopez, Andrea, Reyna, Denis E., Gitego, Nadege, Kopp, Felix, Zhou, Hua, Miranda-Roman, Miguel A., Nordstrøm, Lars Ulrik, Narayanagari, Swathi-Rao, Chi, Ping, Vilar, Eduardo, Tsirigos, Aristotelis, Gavathiotis, Evripidis

“…Deregulation of the BCL-2 family interaction network ensures cancer resistance to apoptosis and is a major challenge to current treatments. Cancer cells…”
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Eltrombopag directly inhibits BAX and prevents cell death by Spitz, Adam Z., Zacharioudakis, Emmanouil, Reyna, Denis E., Garner, Thomas P., Gavathiotis, Evripidis

“…The BCL-2 family protein BAX has essential activity in mitochondrial regulation of cell death. While BAX activity ensures tissue homeostasis, when dysregulated…”
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An interconnected hierarchical model of cell death regulation by the BCL-2 family by Chen, Hui-Chen, Kanai, Masayuki, Inoue-Yamauchi, Akane, Tu, Ho-Chou, Huang, Yafen, Ren, Decheng, Kim, Hyungjin, Takeda, Shugaku, Reyna, Denis E., Chan, Po M., Ganesan, Yogesh Tengarai, Liao, Chung-Ping, Gavathiotis, Evripidis, Hsieh, James J., Cheng, Emily H.

“…Multidomain pro-apoptotic BAX and BAK, once activated, permeabilize mitochondria to trigger apoptosis, whereas anti-apoptotic BCL-2 members preserve…”
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BH3-Triggered Structural Reorganization Drives the Activation of Proapoptotic BAX by Gavathiotis, Evripidis, Reyna, Denis E., Davis, Marguerite L., Bird, Gregory H., Walensky, Loren D.

“…BAX is a proapoptotic BCL-2 family member that lies dormant in the cytosol until converted into a killer protein in response to cellular stress. Having…”
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Direct and selective small-molecule activation of proapoptotic BAX by Gavathiotis, Evripidis, Reyna, Denis E, Bellairs, Joseph A, Leshchiner, Elizaveta S, Walensky, Loren D

“…A computational screen identifies a small-molecule activator of proapoptotic BAX that selectively binds to the BAX trigger site, inducing characteristic…”
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An Autoinhibited Dimeric Form of BAX Regulates the BAX Activation Pathway by Garner, Thomas P., Reyna, Denis E., Priyadarshi, Amit, Chen, Hui-Chen, Li, Sheng, Wu, Yang, Ganesan, Yogesh Tengarai, Malashkevich, Vladimir N., Cheng, Emily H., Gavathiotis, Evripidis

“…Pro-apoptotic BAX is a cell fate regulator playing an important role in cellular homeostasis and pathological cell death. BAX is predominantly localized in the…”
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Bax regulates primary necrosis through mitochondrial dynamics by Whelan, Russell S, Konstantinidis, Klitos, Wei, An-Chi, Chen, Yun, Reyna, Denis E, Jha, Saurabh, Yang, Ying, Calvert, John W, Lindsten, Tullia, Thompson, Craig B, Crow, Michael T, Gavathiotis, Evripidis, Dorn, Gerald W. II, O'Rourke, Brian, Kitsis, Richard N

“…The defining event in apoptosis is mitochondrial outer membrane permeabilization (MOMP), allowing apoptogen release. In contrast, the triggering event in…”
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An Autoinhibited Dimeric Form of BAX Regulates the BAX Activation Pathway by Garner, Thomas P., Reyna, Denis E., Priyadarshi, Amit, Chen, Hui-Chen, Li, Sheng, Wu, Yang, Ganesan, Yogesh Tengarai, Malashkevich, Vladimir N., Cheng, Emily H., Gavathiotis, Evripidis

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Small-molecule allosteric inhibitors of BAX by Garner, Thomas P., Amgalan, Dulguun, Reyna, Denis E., Li, Sheng, Kitsis, Richard N., Gavathiotis, Evripidis

“…BAX is a critical effector of the mitochondrial cell death pathway in response to a diverse range of stimuli in physiological and disease contexts. Upon…”
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Progress in targeting the BCL-2 family of proteins by Garner, Thomas P, Lopez, Andrea, Reyna, Denis E, Spitz, Adam Z, Gavathiotis, Evripidis

“…[Display omitted] •Selective BH3 mimetics for interrogating the BCL-2 protein family interactions and their development for cancer therapy.•Non-canonical…”
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Direct Activation of BAX by BTSA1 Overcomes Apoptosis Resistance in Acute Myeloid Leukemia by Reyna, Denis E., Garner, Thomas P., Lopez, Andrea, Kopp, Felix, Choudhary, Gaurav S., Sridharan, Ashwin, Narayanagari, Swathi-Rao, Mitchell, Kelly, Dong, Baoxia, Bartholdy, Boris A., Walensky, Loren D., Verma, Amit, Steidl, Ulrich, Gavathiotis, Evripidis

“…The BCL-2 family protein BAX is a central mediator of apoptosis. Overexpression of anti-apoptotic BCL-2 proteins contributes to tumor development and…”
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Self-regulation of BAX-induced cell death by Reyna, Denis E, Gavathiotis, Evripidis

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Pulling the BAX trigger for tumor cell death by Reyna, Denis E, Gavathiotis, Evripidis

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Apoptosis signaling molecules as treatment targets in head and neck squamous cell carcinoma by Ow, Thomas J., Thomas, Carlos, Fulcher, Cory D., Chen, Jianhong, López, Andrea, Reyna, Denis E., Prystowsky, Michael B., Smith, Richard V., Schiff, Bradley A., Rosenblatt, Gregory, Belbin, Thomas J., Harris, Thomas M., Childs, Geoffrey C., Kawachi, Nicole, Schlecht, Nicolas F., Gavathiotis, Evripidis

“…Objectives To evaluate BCL‐2 family signaling molecules in head and neck squamous cell carcinoma (HNSCC) and examine the ability of therapeutic agents with…”
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Optimal targeting of BCL-family proteins in head and neck squamous cell carcinoma requires inhibition of both BCL-xL and MCL-1 by Ow, Thomas J, Fulcher, Cory D, Thomas, Carlos, Broin, Pilib Ó, López, Andrea, Reyna, Denis E, Smith, Richard V, Sarta, Catherine, Prystowsky, Michael B, Schlecht, Nicolas F, Schiff, Bradley A, Rosenblatt, Gregory, Belbin, Thomas J, Harris, Thomas M, Childs, Geoffrey C, Kawachi, Nicole, Guha, Chandan, Gavathiotis, Evripidis

“…Mechanisms of treatment resistance in head and neck squamous cell carcinoma (HNSCC) are not well characterized. In this study, HNSCC tumors from a cohort of…”
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In Response to Regarding: Apoptosis Signaling Molecules as Treatment Targets in Head and Neck Squamous Carcinoma by Ow, Thomas J., Thomas, Carlos, Fulcher, Cory D., Chen, Jianhong, López, Andrea, Reyna, Denis E., Prystowsky, Michael B., Smith, Richard V., Schiff, Bradley A., Rosenblatt, Gregory, Belbin, Thomas J., Harris, Thomas M., Childs, Geoffrey C., Kawachi, Nicole, Schlecht, Nicolas F., Gavathiotis, Evripidis

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Abstract 1654: Chemical and structure-guided optimization of BAX trigger site activators for cancer therapy by Reyna, Denis E., Kopp, Felix, Gavathiotis, Evripidis

“…Abstract Cancer cells evade mitochondrial apoptosis most commonly by over-expressing anti-apoptotic BCL-2 proteins that suppress the activation of…”
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Abstract 2455: BAM38 is a potent and selective pro-apoptotic BAX activator molecule that restores apoptosis in cancer cells by Reyna, Denis E., Walensky, Loren D., Gavathiotis, Evripidis

“…Abstract Targeting key apoptosis regulators to overcome the apoptotic resistance of cancer cells is a highly attractive therapeutic strategy. The BCL-2 protein…”
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Reply to “Regarding: Apoptosis Signaling Molecules as Treatment Targets in Head and Neck Squamous Carcinoma” by Ow, Thomas J., Thomas, Carlos, Fulcher, Cory D., Chen, Jianhong, López, Andrea, Reyna, Denis E., Prystowsky, Michael B., Smith, Richard V., Schiff, Bradley A., Rosenblatt, Gregory, Belbin, Thomas J., Harris, Thomas M., Childs, Geoffrey C., Kawachi, Nicole, Schlecht, Nicolas F., Gavathiotis, Evripidis

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BH3-Triggered Structural Reorganization Drives the Activation of Pro-apoptotic BAX by Gavathiotis, Evripidis, Reyna, Denis E., Davis, Marguerite L., Bird, Gregory H., Walensky, Loren D.

“…BAX is a pro-apoptotic BCL-2 family member that lies dormant in the cytosol until converted into a killer protein in response to cellular stress. Having…”
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