Search Results - "Reymond, J L"

Isolation and Biochemical Characterization of Two Novel Metagenome-Derived Esterases by Elend, C, Schmeisser, C, Leggewie, C, Babiak, P, Carballeira, J.D, Steele, H.L, Reymond, J.-L, Jaeger, K.-E, Streit, W.R

“…The metagenomes of uncultured microbial communities are rich sources for novel biocatalysts. In this study, esterase EstA3 was derived from a drinking water…”
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X-ray structure of a lectin-bound DNA duplex containing an unnatural phenanthrenyl pair by Roethlisberger, P, Istrate, A, Marcaida Lopez, M J, Visini, R, Stocker, A, Reymond, J-L, Leumann, C J

“…DNA duplexes containing unnatural base-pair surrogates are attractive biomolecular nanomaterials with potentially beneficial photophysical or electronic…”
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What we have learned from crystal structures of proteins to receptor function by Reymond, J.-L., van Deursen, Ruud, Bertrand, D.

“…The activity of ligand gated channels is crucial for proper brain function and dysfunction of a single receptor subtype have led to neurological impairments…”
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High-throughput screening for biocatalysts by Wahler, Denis, Reymond, Jean-Louis

“…Recent progress in high-throughput enzyme assays includes new examples of fluorogenic and chromogenic substrates, fluorescence resonance energy transfer…”
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A High-Throughput, Low-Volume Enzyme Assay on Solid Support by Babiak, Peter, Reymond, Jean-Louis

“…A high-throughput enzyme assay is described that uses 1 μL or less of enzyme solution for each test. Enzyme solutions are deposited by robotic handling in a…”
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Enzyme assays for high-throughput screening by Goddard, Jean-Philippe, Reymond, Jean-Louis

“…Assaying enzyme-catalyzed transformations in high-throughput is crucial to enzyme discovery, enzyme engineering and the drug discovery process. In enzyme…”
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An enantioselective fluorimetric assay for alcohol dehydrogenases using albumin-catalyzed β-elimination of umbelliferone by Klein, Gérard, Reymond, Jean-Louis

“…3-hydroxybutyl umbelliferyl ethers (R)- 1 and (S)- 1 are fluorogenic substrates for alcohol dehydrogenases. Their oxidation forms ketone 2, which undergoes…”
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Dendrimers as artificial enzymes by Kofoed, Jacob, Reymond, Jean-Louis

“…Dendrimers are regular tree-like macromolecules accessible by chemical synthesis from a variety of building blocks. Their topology enforces a globular shape…”
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Novel peptide-dendrimer/lipid/oligonucleotide ternary complexes for efficient cellular uptake and improved splice-switching activity by Saher, Osama, Rocha, Cristina S.J., Zaghloul, Eman M., Wiklander, Oscar P.B., Zamolo, Susanna, Heitz, Marc, Ezzat, Kariem, Gupta, Dhanu, Reymond, Jean-Louis, Zain, Rula, Hollfelder, Florian, Darbre, Tamis, Lundin, Karin E., EL Andaloussi, Samir, Smith, C.I. Edvard

“…[Display omitted] Despite the advances in gene therapy and in oligonucleotide (ON) chemistry, efficient cellular delivery remains an obstacle. Most current…”
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A General Assay for Antibody Catalysis Using Acridone as a Fluorescent Tag by Reymond, Jean-Louis, Koch, Thomas, Schröer, Josef, Tierney, Emily

“…A simple and highly sensitive catalysis assay is demonstrated based on analyzing reactions with acridone-tagged compounds by thin-layer chromatography. As…”
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Recent advances in enzyme assays by Goddard, Jean-Philippe, Reymond, Jean-Louis

“…Enzyme assays for high-throughput screening and enzyme engineering, which are often based on derivatives of coumarin, nitrophenol, fluorescein,…”
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Antibody catalysis of a reaction otherwise strongly disfavoured in water by Shabat, Doron, Itzhaky, Harel, Reymond, Jean-Louis, Keinan, Ehud

“…Several examples have been reported recently of antibody catalysis of reactions that are strongly disfavoured because of the high free energy of the transition…”
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Phosphofurylalanine, a stable analog of phosphohistidine by Schenkels, Caroline, Erni, Bernhard, Reymond, Jean-Louis

“…Phosphorylated histidine residues occur in a number of signal-transduction pathways in bacteria as well as in eukaryotes. Phosphohistidine is hydrolytically…”
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Novel methods for biocatalyst screening by Wahler, Denis, Reymond, Jean-Louis

“…There have been a number of recent advances in catalysis assays applicable for screening biocatalyst libraries in high-throughput format. These include…”
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Selective Catalysis with Peptide Dendrimers by Douat-Casassus, Céline, Darbre, Tamis, Reymond, Jean-Louis

“…Peptide dendrimers incorporating 3,5-diaminobenzoic acid 1 as a branching unit (B) were prepared by solid-phase synthesis of ((Ac−A3)2B−A2)2B−Cys−A1−NH2…”
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Lipophilic Peptide Dendrimers for Delivery of Splice-Switching Oligonucleotides by Daralnakhla, Haneen, Saher, Osama, Zamolo, Susanna, Bazaz, Safa, P Bost, Jeremy, Heitz, Marc, Lundin, Karin E, El Andaloussi, Samir, Darbre, Tamis, Reymond, Jean-Louis, Zain, Rula, Smith, C I Edvard

“…Non-viral transfection reagents are continuously being developed in attempt to replace viral vectors. Among those non-viral vectors, dendrimers have gained…”
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Antibody-Catalyzed Reversal of Chemoselectivity by Sinha, Subhash C., Keinan, Ehud, Reymond, Jean-Louis

“…A monoclonal antibody, 14D9, which has been elicited against a cationic hapten, N-alkyl-N-methyl-3-glutarylamidomethyl piperidinium, in which alkyl =…”
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Antibody catalyzed hydrolysis of enol ethers by Reymond, Jean Louis, Jahangiri, Guiti K, Stoudt, Catherine, Lerner, Richard A

“…The hydrolysis of alkyl enol ethers to their corresponding carbonyl compounds proceeds by rate determining protonation of the beta -carbon to form an activated…”
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Antibody-catalyzed enantioselective epoxide hydrolysis by Sinha, Subhash C, Keinan, Ehud, Reymond, Jean Louis

“…Acid-catalyzed opening of epoxides is not a trivial process, as the reaction may lead to a number of products, depending on the substrate and reaction…”
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Classifying Enzymes from Selectivity Fingerprints by Grognux, Johann, Reymond, Jean-Louis

“…Fingerprints of lipases and esterases have been recorded by using an array of chiral fluorogenic aliphatic esters of increasing chain length (C₄-C₁₆)…”
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