Search Results - "Reyland, Mary E."

Salivary Gland Hypofunction and Xerostomia in Head and Neck Radiation Patients by Jensen, Siri Beier, Vissink, Arjan, Limesand, Kirsten H, Reyland, Mary E

“…The most manifest long-term consequences of radiation therapy in the head and neck cancer patient are salivary gland hypofunction and a sensation of oral…”
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Protein kinase C isoforms: Multi-functional regulators of cell life and death by Reyland, Mary E

“…The protein kinase C (PKC) family consists of 10 related serine/threonine protein kinases some of which are critical regulators of cell proliferation, survival…”
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Clinical Management of Salivary Gland Hypofunction and Xerostomia in Head-and-Neck Cancer Patients: Successes and Barriers by Vissink, Arjan, D.D.S., M.D., Ph.D, Mitchell, James B., Ph.D, Baum, Bruce J., D.D.S., Ph.D, Limesand, Kirsten H., Ph.D, Jensen, Siri Beier, D.D.S., Ph.D, Fox, Philip C., D.D.S, Elting, Linda S., Dr.P.H, Langendijk, Johannes A., M.D., Ph.D, Coppes, Robert P., Ph.D, Reyland, Mary E., Ph.D

“…The most significant long-term complication of radiotherapy in the head-and-neck region is hyposalivation and its related complaints, particularily xerostomia…”
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Mechanisms of taste bud cell loss after head and neck irradiation by Nguyen, Ha M, Reyland, Mary E, Barlow, Linda A

“…Taste loss in human patients following radiotherapy for head and neck cancer is a common and significant problem, but the cellular mechanisms underlying this…”
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Protein kinase C isozymes and the regulation of diverse cell responses by Dempsey, E C, Newton, A C, Mochly-Rosen, D, Fields, A P, Reyland, M E, Insel, P A, Messing, R O

“…Individual protein kinase C (PKC) isozymes have been implicated in many cellular responses important in lung health and disease, including permeability,…”
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PKCα and PKCδ: Friends and Rivals by Black, Jennifer D., Affandi, Trisiani, Black, Adrian R., Reyland, Mary E.

“…PKC comprises a large family of serine/threonine kinases that share a requirement for allosteric activation by lipids. While PKC isoforms have significant…”
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Tyrosine kinase inhibitors protect the salivary gland from radiation damage by increasing DNA double-strand break repair by Affandi, Trisiani, Ohm, Angela M., Gaillard, Dany, Haas, Ami, Reyland, Mary E.

“…We have previously shown that the tyrosine kinase inhibitors (TKIs) dasatinib and imatinib can protect salivary glands from irradiation (IR) damage without…”
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Multifunctional roles of PKCδ: Opportunities for targeted therapy in human disease by Reyland, Mary E, Jones, David N M

“…The serine-threonine protein kinase, protein kinase C-δ (PKCδ), is emerging as a bi-functional regulator of cell death and proliferation. Studies in PKCδ-/-…”
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PKCδ Regulates Chromatin Remodeling and DNA Repair through SIRT6 by Affandi, Trisiani, Haas, Ami, Ohm, Angela M, Wright, Gregory M, Black, Joshua C, Reyland, Mary E

“…Irradiation (IR) is a highly effective cancer therapy; however, IR damage to tumor-adjacent healthy tissues can result in significant comorbidities and…”
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Cleavage of protein kinase c δ by caspase-3 mediates proinflammatory cytokine-induced apoptosis in pancreatic islets by Collins, Jillian, Piscopio, Robert A., Reyland, Mary E., Johansen, Chelsea G., Benninger, Richard K.P., Farnsworth, Nikki L.

“…In type 1 diabetes (T1D), autoreactive immune cells infiltrate the pancreas and secrete proinflammatory cytokines that initiate cell death in insulin producing…”
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RELT family members activate p38 and induce apoptosis by a mechanism distinct from TNFR1 by Moua, Pachai, Checketts, Mathew, Xu, Liang-Guo, Shu, Hong-Bing, Reyland, Mary E., Cusick, John K.

“…Receptor Expressed in Lymphoid Tissues (RELT) is a human Tumor Necrosis Factor Receptor (TNFR) family member that has two identified homologous binding…”
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Metabolic reprogramming contributes to radioprotection by protein kinase Cδ by Ohm, Angela M., Affandi, Trisiani, Reisz, Julie A., Caino, M. Cecilia, D’Alessandro, Angelo, Reyland, Mary E.

“…Loss of protein kinase Cδ (PKCδ) activity renders cells resistant to DNA damaging agents, including irradiation; however, the mechanism(s) underlying…”
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Tyrosine Kinase Inhibitors Protect the Salivary Gland from Radiation Damage by Inhibiting Activation of Protein Kinase C-δ by Wie, Sten M, Wellberg, Elizabeth, Karam, Sana D, Reyland, Mary E

“…In patients undergoing irradiation (IR) therapy, injury to nontumor tissues can result in debilitating, and sometimes permanent, side effects. We have defined…”
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EGF receptor and PKCδ kinase activate DNA damage–induced pro-survival and pro-apoptotic signaling via biphasic activation of ERK and MSK1 kinases by Ohm, Angela M., Affandi, Trisiani, Reyland, Mary E.

“…DNA damage–mediated activation of extracellular signal–regulated kinase (ERK) can regulate both cell survival and cell death. We show here that ERK activation…”
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Loss of MAP3K7 Sensitizes Prostate Cancer Cells to CDK1/2 Inhibition and DNA Damage by Disrupting Homologous Recombination by Washino, Satoshi, Rider, Leah C, Romero, Lina, Jillson, Lauren K, Affandi, Trisiani, Ohm, Angela M, Lam, Elaine T, Reyland, Mary E, Costello, James C, Cramer, Scott D

“…The combined loss of and promotes aggressive prostate cancer by unknown mechanisms. Because both of these genes are lost genetically in prostate cancer, they…”
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Salivary Gland Cancer Patient-Derived Xenografts Enable Characterization of Cancer Stem Cells and New Gene Events Associated with Tumor Progression by Keysar, Stephen B, Eagles, Justin R, Miller, Bettina, Jackson, Brian C, Chowdhury, Farshad N, Reisinger, Julie, Chimed, Tugs-Saikhan, Le, Phuong N, Morton, John J, Somerset, Hilary L, Varella-Garcia, Marileila, Tan, Aik-Choon, Song, John I, Bowles, Daniel W, Reyland, Mary E, Jimeno, Antonio

“…Salivary gland cancers (SGC) frequently present with distant metastases many years after diagnosis, suggesting a cancer stem cell (CSC) subpopulation that…”
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Inhibiting Tyrosine Phosphorylation of Protein Kinase Cδ (PKCδ) Protects the Salivary Gland from Radiation Damage by Wie, Sten M., Adwan, Tariq S., DeGregori, James, Anderson, Steven M., Reyland, Mary E.

“…Radiation therapy for head and neck cancer can result in extensive damage to normal adjacent tissues such as the salivary gland and oral mucosa. We have shown…”
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Functional proteomic analysis reveals roles for PKCδ in regulation of cell survival and cell death: Implications for cancer pathogenesis and therapy by Speidel, Jordan T., Affandi, Trisiani, Jones, David N.M., Ferrara, Sarah E., Reyland, Mary E.

“…Protein Kinase C-δ (PKCδ), regulates a broad group of biological functions and disease processes, including well-defined roles in immune function, cell…”
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Induction of Apoptosis Is Driven by Nuclear Retention of Protein Kinase Cδ by DeVries-Seimon, Tracie A., Ohm, Angela M., Humphries, Michael J., Reyland, Mary E.

“…Protein kinase Cδ (PKCδ) mediates apoptosis downstream of many apoptotic stimuli. Because of its ubiquitous expression, tight regulation of the proapoptotic…”
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PKCδ regulates integrin αVβ3 expression and transformed growth of K-ras dependent lung cancer cells by Symonds, Jennifer M, Ohm, Angela M, Tan, Aik-Choon, Reyland, Mary E

“…We have previously shown that Protein Kinase C delta (PKCδ) functions as a tumor promoter in non-small cell lung cancer (NSCLC), specifically in the context of…”
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