Search Results - "Reyes Fernandez, Perla C"

Examining Mechanisms for Voltage-Sensitive Calcium Channel-Mediated Secretion Events in Bone Cells by Reyes Fernandez, Perla C., Wright, Christian S., Farach-Carson, Mary C., Thompson, William R.

“…In addition to their well-described functions in cell excitability, voltage-sensitive calcium channels (VSCCs) serve a critical role in calcium (Ca 2+…”
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Diet X Gene Interactions Control Femoral Bone Adaptation to Low Dietary Calcium by Chanpaisaeng, Krittikan, Reyes‐Fernandez, Perla C., Dilkes, Brian, Fleet, James C.

“…ABSTRACT Genetics and dietary calcium (Ca) are each critical regulators of peak bone mass but it is unclear how genetics alters the physiologic response of…”
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Dietary calcium intake and genetics have site-specific effects on peak trabecular bone mass and microarchitecture in male mice by Chanpaisaeng, Krittikan, Reyes Fernandez, Perla C., Fleet, James C.

“…Trabecular bone (Tb) is used for rapid exchange of calcium (Ca) in times of physiologic need and the site-specific characteristics of Tb may explain why…”
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Compensatory Changes in Calcium Metabolism Accompany the Loss of Vitamin D Receptor (VDR) From the Distal Intestine and Kidney of Mice by Reyes‐Fernandez, Perla C, Fleet, James C

“…ABSTRACT 1,25 Dihydroxyvitamin D3 (1,25(OH)2D) increases intestinal Ca absorption when dietary Ca intake is low by inducing gene expression through the vitamin…”
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Deletion of the auxiliary α2δ1 voltage sensitive calcium channel subunit in osteocytes and late-stage osteoblasts impairs femur strength and load-induced bone formation in male mice by Wright, Christian S, Lewis, Karl J, Semon, Katelyn, Yi, Xin, Reyes Fernandez, Perla C, Rust, Katie, Prideaux, Matthew, Schneider, Artur, Pederson, Molly, Deosthale, Padmini, Plotkin, Lilian I, Hum, Julia M, Sankar, Uma, Farach-Carson, Mary C, Robling, Alexander G, Thompson, William R

“…Osteocytes sense and respond to mechanical force by controlling the activity of other bone cells. However, the mechanisms by which osteocytes sense mechanical…”
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Effects of Gabapentin and Pregabalin on Calcium Homeostasis: Implications for Physical Rehabilitation of Musculoskeletal Tissues by Reyes Fernandez, Perla C., Wright, Christian S., Warden, Stuart J., Hum, Julia, Farach-Carson, Mary C., Thompson, William R.

“…Purpose of Review In this review, we discuss the mechanism of action of gabapentinoids and the potential consequences of long-term treatment with these drugs…”
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Automated image-analysis method for the quantification of fiber morphometry and fiber type population in human skeletal muscle by Reyes-Fernandez, Perla C, Periou, Baptiste, Decrouy, Xavier, Relaix, Fréderic, Authier, François Jérôme

“…The quantitative analysis of muscle histomorphometry has been growing in importance in both research and clinical settings. Accurate and stringent assessment…”
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Novel Genetic Loci Control Calcium Absorption and Femur Bone Mass as Well as Their Response to Low Calcium Intake in Male BXD Recombinant Inbred Mice by Reyes Fernandez, Perla C, Replogle, Rebecca A, Wang, Libo, Zhang, Min, Fleet, James C

“…ABSTRACT Low dietary calcium (Ca) intake during growth limits peak bone mass but physiological adaptation can prevent this adverse effect. To assess the…”
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Effects of Dietary Protein Source and Quantity on Bone Morphology and Body Composition Following a High-Protein Weight-Loss Diet in a Rat Model for Postmenopausal Obesity by Wright, Christian S, Hill, Erica R, Reyes Fernandez, Perla C, Thompson, William R, Gallant, Maxime A, Campbell, Wayne W, Main, Russell P

“…Higher protein (>30% of total energy, HP)-energy restriction (HP-ER) diets are an effective means to improve body composition and metabolic health. However,…”
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Gabapentin Disrupts Binding of Perlecan to the α2δ1 Voltage Sensitive Calcium Channel Subunit and Impairs Skeletal Mechanosensation by Reyes Fernandez, Perla C., Wright, Christian S., Masterson, Adrianna N., Yi, Xin, Tellman, Tristen V., Bonteanu, Andrei, Rust, Katie, Noonan, Megan L., White, Kenneth E., Lewis, Karl J., Sankar, Uma, Hum, Julia M., Bix, Gregory, Wu, Danielle, Robling, Alexander G., Sardar, Rajesh, Farach-Carson, Mary C., Thompson, William R.

“…Our understanding of how osteocytes, the principal mechanosensors within bone, sense and perceive force remains unclear. Previous work identified “tethering…”
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Male Lrp5A214V mice maintain high bone mass during dietary calcium restriction by altering the vitamin D endocrine system by Ozgurel, Serra Ucer, Reyes Fernandez, Perla C, Chanpaisaeng, Krittikan, Fleet, James C

“…Environmental factors and genetic variation individually impact bone. However, it is not clear how these factors interact to influence peak bone mass accrual…”
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Luminal glucose does not enhance active intestinal calcium absorption in mice: evidence against a role for Ca(v)1.3 as a mediator of calcium uptake during absorption by Reyes-Fernandez, Perla C, Fleet, James C

“…Intestinal Ca absorption occurs through a 1,25-dihydroxyvitamin D3 (1,25(OH)2D3)-regulated transcellular pathway, especially when habitual dietary Ca intake is…”
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Gabapentin Disrupts Binding of Perlecan to the α[sub.2]δ[sub.1] Voltage Sensitive Calcium Channel Subunit and Impairs Skeletal Mechanosensation by Reyes Fernandez, Perla C, Wright, Christian S, Masterson, Adrianna N, Yi, Xin, Tellman, Tristen V, Bonteanu, Andrei, Rust, Katie, Noonan, Megan L, White, Kenneth E, Lewis, Karl J, Sankar, Uma, Hum, Julia M, Bix, Gregory, Wu, Danielle, Robling, Alexander G, Sardar, Rajesh, Farach-Carson, Mary C, Thompson, William R

“…Our understanding of how osteocytes, the principal mechanosensors within bone, sense and perceive force remains unclear. Previous work identified “tethering…”
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Loss of the auxiliary α2δ1 voltage-sensitive calcium channel subunit impairs bone formation and anabolic responses to mechanical loading by Kelly, Madison M, Sharma, Karan, Wright, Christian S, Yi, Xin, Reyes Fernandez, Perla C, Gegg, Aaron T, Gorrell, Taylor A, Noonan, Megan L, Baghdady, Ahmed, Sieger, Jacob A, Dolphin, Annette C, Warden, Stuart J, Deosthale, Padmini, Plotkin, Lilian I, Sankar, Uma, Hum, Julia M, Robling, Alexander G, Farach-Carson, Mary C, Thompson, William R

“…Voltage-sensitive calcium channels (VSCCs) influence bone structure and function, including anabolic responses to mechanical loading. While the pore-forming…”
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Luminal glucose does not enhance active intestinal calcium absorption in mice: evidence against a role for Cav1.3 as a mediator of calcium uptake during absorption by Reyes-Fernandez, Perla C., Fleet, James C.

“…Intestinal Ca absorption occurs through a 1,25-dihydroxyvitamin D3 (1,25(OH)2D3)–regulated transcellular pathway, especially when habitual dietary Ca intake is…”
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Femoral and L5 Spine Trabecular Bone Are Differentially Influenced by Dietary Calcium Restriction and Genetics in Growing Mice by Chanpaisaeng, Krittikan, Reyes‐Fernandez, Perla C., Mace, Sarah, Replegle, Rebecca A., Lan, Xu, Fleet, James C.

“…Abstract only Trabecular bone (Tb) has a high surface‐to‐mass ratio that makes it valuable for rapid exchange of calcium (Ca) ions in times of physiologic need…”
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Multi‐Trait Genetic Mapping Reveals Novel Loci Responsible for Genetic and Genetic‐by‐Diet Interactions Affecting Bone, Vitamin D, and Calcium Metabolism by Fleet, James C., Reyes‐Fernandez, Perla C., Replegle, Rebecca A., Chanpaisaeng, Krittikan

“…Abstract only Attaining maximal Peak Bone Mass (PBM) is a critical approach for reducing the lifetime risk of osteoporosis. While PBM is compromised by…”
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Luminal glucose does not enhance active intestinal calcium absorption in mice: evidence against a role for Cav 1.3 as a mediator of calcium uptake during absorption by Reyes-Fernandez, Perla C, Fleet, James C

“…Abstract Intestinal Ca absorption occurs through a 1,25-dihydroxyvitamin D3 (1,25(OH)2 D3 )–regulated transcellular pathway, especially when habitual dietary…”
Get full text

Loss of the auxiliary α 2 δ 1 voltage-sensitive calcium channel subunit impairs bone formation and anabolic responses to mechanical loading by Kelly, Madison M, Sharma, Karan, Wright, Christian S, Yi, Xin, Reyes Fernandez, Perla C, Gegg, Aaron T, Gorrell, Taylor A, Noonan, Megan L, Baghdady, Ahmed, Sieger, Jacob A, Dolphin, Annette C, Warden, Stuart J, Deosthale, Padmini, Plotkin, Lilian I, Sankar, Uma, Hum, Julia M, Robling, Alexander G, Farach-Carson, Mary C, Thompson, William R

“…Voltage-sensitive calcium channels (VSCCs) influence bone structure and function, including anabolic responses to mechanical loading. While the pore-forming (α…”
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Gabapentin Disrupts Binding of Perlecan to the α 2 δ 1 Voltage Sensitive Calcium Channel Subunit and Impairs Skeletal Mechanosensation by Reyes Fernandez, Perla C, Wright, Christian S, Masterson, Adrianna N, Yi, Xin, Tellman, Tristen V, Bonteanu, Andrei, Rust, Katie, Noonan, Megan L, White, Kenneth E, Lewis, Karl J, Sankar, Uma, Hum, Julia M, Bix, Gregory, Wu, Danielle, Robling, Alexander G, Sardar, Rajesh, Farach-Carson, Mary C, Thompson, William R

“…Our understanding of how osteocytes, the principal mechanosensors within bone, sense and perceive force remains unclear. Previous work identified "tethering…”
Get full text