Association of AMY1A/AMY2A copy numbers and AMY1/AMY2 serum enzymatic activity with obesity in Mexican children

SUMMARY Background Mexican children are characterized by a high‐starch intake diet and high prevalence of obesity. Objectives To investigate the association of AMY1A/AMY2A copy numbers (CNs) and AMY1/AMY2 serum enzymatic activity with childhood obesity in up to 427 and 337 Mexican cases and controls...

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Published in:	Pediatric obesity Vol. 15; no. 8; pp. e12641 - n/a
Main Authors:	Vázquez‐Moreno, Miguel, Mejía‐Benítez, Aurora, Sharma, Tanmay, Peralta‐Romero, Jesús, Locia‐Morales, Daniel, Klünder‐Klünder, Miguel, Álvarez‐Villaseñor, Andrea S., Acosta, Kelly G., Flores‐Torrecillas, Raquel, Flores‐Osuna, Uriel, García‐Avilés, Mariell G., González‐Dzib, Roxana S., Gameros‐Gardea, René A., Pizano‐Zárate, María L., Romero‐Figueroa, María S., Núñez‐Hernández, Jorge A., León‐Camacho, Verónica, Karam‐Araujo, Roberto, Corona‐Salazar, Perla, Valladares‐Salgado, Adán, Suarez‐Sánchez, Fernando, Gómez‐Zamudio, Jaime, Flores‐Alfaro, Eugenia, Sosa‐Bustamante, Gloria P., Reyes‐Hernández, Arturo, Peralta‐Cortázar, Catalina, Martínez‐Morales, Emmanuel G., Díaz de León‐Morales, Luz V., González‐González, Irma L. C., Reyes‐Sosa, Arturo M., Lazcano‐Bautista, Sonia, Martínez‐Chávez, Marcela, González‐Serrano, Fátima D., Rodríguez‐Alfaro, Alma N., Murillo‐Ortiz, Blanca O., Arteaga‐Alcaraz, María G., García‐Silva, Nandy, Herrera‐Lemus, Moisés, Gómez‐Arteaga, Gress M., Gómez‐García, Anel, Urbina‐Treviño, Martha V., Villalpando‐Sánchez, Diana C., Álvarez‐Aguilar, Cleto, Jiménez‐Arredondo, Ramón E., Dávila‐Rodríguez, Martha I., González‐Salazar, Francisco, Garza‐Salinas, Laura H., Pérez‐Herrera, Aleyda, Méndez‐Martínez, Socorro, Martínez‐Torres, Jorge, Méndez‐Fernández, Elizabeth, Segura‐Bonilla, Víctor A., Gutiérrez‐Hernández, Mariana, Gallardo‐Vidal, Lilia S., Blanco‐Castillo, Leticia, García‐González, José J., Medina‐Serrano, Julio M., Canizalez‐Román, Adrián, López‐Morales, Cruz M., Valle‐Leal, Jaime G., Segura‐Chico, Martin, Violenté‐Ortiz, Rafael, Fernández‐Jiménez, Verónica, Sánchez‐Hernández, Norma A., Cruz, Miguel, Meyre, David
Format:	Journal Article
Language:	English
Published:	Chichester, UK John Wiley & Sons, Inc 01-08-2020 Wiley Subscription Services, Inc
Subjects:	amylase Child childhood obesity Childrens health copy‐number variants dietary starch intake enzyme activity Enzymes Female Gene Dosage Humans Male Meta-Analysis as Topic Mexican population Obesity Pancreatic alpha-Amylases - blood Pancreatic alpha-Amylases - genetics Pediatric Obesity - enzymology Pediatric Obesity - etiology Pediatrics Salivary alpha-Amylases - blood Salivary alpha-Amylases - genetics Mexican population amylase copy-number variants dietary starch intake enzyme activity childhood obesity
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Summary:	SUMMARY Background Mexican children are characterized by a high‐starch intake diet and high prevalence of obesity. Objectives To investigate the association of AMY1A/AMY2A copy numbers (CNs) and AMY1/AMY2 serum enzymatic activity with childhood obesity in up to 427 and 337 Mexican cases and controls. Methods Anthropometric and dietary starch intake data were collected. CN of AMY1A/AMY2A and AMY1/AMY2 serum enzymatic activity were determined using droplet digital PCR (ddPCR) and enzymatic colorimetry, respectively. An individual participant level data meta‐analysis of association between AMY1A CNVs and obesity was also performed. Results A positive association between AMY1A/AMY2A CNs and their corresponding AMY1/AMY2 serum enzyme activity was observed in children with normal weight and obesity. The serum enzyme activity of AMY1 and AMY2 was negatively associated with childhood obesity risk, and the association was restricted to kids eating medium/high amount of starch (Pinteraction = .004). While no association between AMY1A and AMY2A CNs and childhood obesity was observed in our sample, we confirmed a significant association between AMY1A CN and obesity in a meta‐analysis of 3100 Mexican children. Conclusions Our data suggest that genetically determined salivary and pancreatic amylase activity can increase/decrease the risk of obesity in Mexican children, this effect being blunted by a low‐starch diet.
Bibliography:	Funding information Canada Research Chairs; Consejo Nacional de Ciencia y Tecnología; Instituto Mexicano del Seguro Social; Ciencias Médicas Odontológicas y de la Salud PhD program from Universidad Nacional Autónoma de México; Mexican Institute of Social Security under the program of Priority Health Topics 2017 Investigators listed in Appendix. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2047-6302 2047-6310
DOI:	10.1111/ijpo.12641