Impact of presentation timing in metastatic hormone‐sensitive prostate cancer: Characterization of patients and identification of prognostic factors

Impact of presentation timing in metastatic hormone‐sensitive prostate cancer: Characterization of patients and identification of prognostic factors

Background The treatment and surveillance of metastatic hormone‐sensitive prostate cancer (mHSPC) has evolved since the introduction of several treatment intensification options associated with hormonal blockade and classifications based on the timing of metastatic disease presentation and disease v...

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Published in:The Prostate Vol. 84; no. 6; pp. 560 - 569
Main Authors: Hoyos, Juliana Arenas, Londoño, David Ruiz, Hoyos, Andres Gomez, Reyes, Estefania Celis, Varela, Rodolfo, Giraldo, Julian Serrano
Format: Journal Article
Language:English
Published: United States Wiley Subscription Services, Inc 01-05-2024
Subjects:
Castration
Hormones
Humans
Male
Medical prognosis
Metastases
Metastasis
Multivariate analysis
Patients
Population studies
Prognosis
Proportional Hazards Models
Prostate cancer
prostatic neoplasms
Prostatic Neoplasms, Castration-Resistant - pathology
Regression analysis
relapse‐free survival
Retrospective Studies
Risk factors
Survival
survival analysis
prostate cancer
survival analysis
prostatic neoplasms
relapse‐free survival
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Summary:Background The treatment and surveillance of metastatic hormone‐sensitive prostate cancer (mHSPC) has evolved since the introduction of several treatment intensification options associated with hormonal blockade and classifications based on the timing of metastatic disease presentation and disease volume. Using a hospital‐based registry, we aimed to assess whether these new classifications are applicable to our population, as few studies have demonstrated their prognostic value for overall survival (OS) and time to development of castration‐resistant prostate cancer (CRPC), and to establish prognostic factors in our population. Methods A retrospective cohort of mHSPC patients who were attended at an oncology referral hospital in Bogota between 2017 and 2021 were included in this study. The primary and secondary endpoints were OS and time to CRPC. The distribution of outcome measures was estimated using the Kaplan–Meier method. Proportional hazard models were constructed using the Cox regression approach and stratified according to risk factors. Results The study cohort included 373 patients. The median castration resistance‐free survival was 48 months (CI: 32–73 months), and OS was 43 months (CI: 37–48 months). In multivariate analysis, nodal staging, ECOG status, and surgical castration were independent prognostic factors. Conclusion In our hospital‐based registry, the independent impact of the time of presentation on castration‐resistant‐free survival or OS could not be demonstrated, nor could the grouping of prognostic categories based on metastatic presentation temporality and volume. Other independent prognostic factors have been proposed.
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ISSN:0270-4137
1097-0045
DOI:10.1002/pros.24672