Search Results - "Reyes, Allan R."

Probing the enzyme kinetics, allosteric modulation and activation of α1- and α2-subunit-containing AMP-activated protein kinase (AMPK) heterotrimeric complexes by pharmacological and physiological activators by Rajamohan, Francis, Reyes, Allan R, Frisbie, Richard K, Hoth, Lise R, Sahasrabudhe, Parag, Magyar, Rachelle, Landro, James A, Withka, Jane M, Caspers, Nicole L, Calabrese, Matthew F, Ward, Jessica, Kurumbail, Ravi G

“…AMP-activated protein kinase (AMPK) is a serine/threonine protein kinase that serves as a pleotropic regulator of whole body energy homoeostasis. AMPK exists…”
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Crystal structure of human lysosomal acid lipase and its implications in cholesteryl ester storage disease[S] by Rajamohan, Francis, Reyes, Allan R., Tu, Meihua, Nedoma, Nicole L., Hoth, Lise R., Schwaid, Adam G., Kurumbail, Ravi G., Ward, Jessica, Han, Seungil

“…Lysosomal acid lipase (LAL) is a serine hydrolase that hydrolyzes cholesteryl ester (CE) and TGs delivered to the lysosomes into free cholesterol and fatty…”
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Expression and functional characterization of human lysosomal acid lipase gene (LIPA) mutation responsible for cholesteryl ester storage disease (CESD) phenotype by Rajamohan, Francis, Reyes, Allan R., Ruangsiriluk, Wanida, Hoth, Lise R., Han, Seungil, Caspers, Nicole, Tu, Meihua, Ward, Jessica, Kurumbail, Ravi G.

“…•Mutations in lysosomal acid lipase are associated with Wolman disease and CESD.•Patients homozygous for His295Tyr (H295Y) mutation have <5% of normal LAL…”
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Genetic manipulation of lysine catabolism in maize kernels by Reyes, Allan R, Bonin, Christopher P, Houmard, Nancy M, Huang, Shihshieh, Malvar, Thomas M

“…In plants, lysine catabolism is thought to be controlled by a bifunctional enzyme, lysine ketoglutarate reductase/saccharopine dehydrogenase (LKR/SDH). Lysine…”
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Activation of Skeletal Muscle AMPK Promotes Glucose Disposal and Glucose Lowering in Non-human Primates and Mice by Cokorinos, Emily C., Delmore, Jake, Reyes, Allan R., Albuquerque, Bina, Kjøbsted, Rasmus, Jørgensen, Nicolas O., Tran, Jean-Luc, Jatkar, Aditi, Cialdea, Katherine, Esquejo, Ryan M., Meissen, John, Calabrese, Matthew F., Cordes, Jason, Moccia, Robert, Tess, David, Salatto, Christopher T., Coskran, Timothy M., Opsahl, Alan C., Flynn, Declan, Blatnik, Matthew, Li, Wenlin, Kindt, Erick, Foretz, Marc, Viollet, Benoit, Ward, Jessica, Kurumbail, Ravi G., Kalgutkar, Amit S., Wojtaszewski, Jørgen F.P., Cameron, Kimberly O., Miller, Russell A.

“…The AMP-activated protein kinase (AMPK) is a potential therapeutic target for metabolic diseases based on its reported actions in the liver and skeletal…”
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Discovery and Preclinical Characterization of 6‑Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]‑1H‑indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy by Cameron, Kimberly O, Kung, Daniel W, Kalgutkar, Amit S, Kurumbail, Ravi G, Miller, Russell, Salatto, Christopher T, Ward, Jessica, Withka, Jane M, Bhattacharya, Samit K, Boehm, Markus, Borzilleri, Kris A, Brown, Janice A, Calabrese, Matthew, Caspers, Nicole L, Cokorinos, Emily, Conn, Edward L, Dowling, Matthew S, Edmonds, David J, Eng, Heather, Fernando, Dilinie P, Frisbie, Richard, Hepworth, David, Landro, James, Mao, Yuxia, Rajamohan, Francis, Reyes, Allan R, Rose, Colin R, Ryder, Tim, Shavnya, Andre, Smith, Aaron C, Tu, Meihua, Wolford, Angela C, Xiao, Jun

“…Adenosine monophosphate-activated protein kinase (AMPK) is a protein kinase involved in maintaining energy homeostasis within cells. On the basis of human…”
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Structural studies identify angiotensin II receptor blocker-like compounds as branched-chain ketoacid dehydrogenase kinase inhibitors by Liu, Shenping, Kormos, Bethany L., Knafels, John D., Sahasrabudhe, Parag V., Rosado, Amy, Sommese, Ruth F., Reyes, Allan R., Ward, Jessica, Roth Flach, Rachel J., Wang, Xiaochun, Buzon, Leanne M., Reese, Matthew R., Bhattacharya, Samit K., Omoto, Kiyoyuki, Filipski, Kevin J.

“…The mammalian mitochondrial branched-chain ketoacid dehydrogenase (BCKD) complex is a multienzyme complex involved in the catabolism of branched-chain amino…”
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Discovery of First Branched-Chain Ketoacid Dehydrogenase Kinase (BDK) Inhibitor Clinical Candidate PF-07328948 by Filipski, Kevin J., Martinez-Alsina, Luis A., Reese, Matthew R., Evrard, Edelweiss, Buzon, Leanne M., Cameron, Kimberly O., Zhang, Yuan, Coffman, Karen J., Bradow, James, Kormos, Bethany L., Liu, Shenping, Knafels, John D., Sahasrabudhe, Parag V., Chen, Jie, Kalgutkar, Amit S., Bessire, Andrew J., Orozco, Christine C., Balesano, Amanda, Cerny, Matthew A., Bollinger, Eliza, Reyes, Allan R., Laforest, Brigitte, Rosado, Amy, Williams, George, Marshall, Mackenzie, Tam Neale, Kelly, Chen, Xian, Hirenallur-Shanthappa, Dinesh, Stansfield, John C., Groarke, John, Qiu, Ruolun, Karas, Spinel, Roth Flach, Rachel J., Esler, William P.

“…Inhibition of branched-chain ketoacid dehydrogenase kinase (BDK or BCKDK), a negative regulator of branched-chain amino acid (BCAA) metabolism, is hypothesized…”
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Small molecule branched-chain ketoacid dehydrogenase kinase (BDK) inhibitors with opposing effects on BDK protein levels by Roth Flach, Rachel J., Bollinger, Eliza, Reyes, Allan R., Laforest, Brigitte, Kormos, Bethany L., Liu, Shenping, Reese, Matthew R., Martinez Alsina, Luis A., Buzon, Leanne, Zhang, Yuan, Bechle, Bruce, Rosado, Amy, Sahasrabudhe, Parag V., Knafels, John, Bhattacharya, Samit K., Omoto, Kiyoyuki, Stansfield, John C., Hurley, Liam D., Song, LouJin, Luo, Lina, Breitkopf, Susanne B., Monetti, Mara, Cunio, Teresa, Tierney, Brendan, Geoly, Frank J., Delmore, Jake, Siddall, C. Parker, Xue, Liang, Yip, Ka N., Kalgutkar, Amit S., Miller, Russell A., Zhang, Bei B., Filipski, Kevin J.

“…Branched chain amino acid (BCAA) catabolic impairments have been implicated in several diseases. Branched chain ketoacid dehydrogenase (BCKDH) controls the…”
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Acyl Glucuronide Metabolites of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1 H-indole-3-carboxylic Acid (PF-06409577) and Related Indole-3-carboxylic Acid Derivatives are Direct Activators of Adenosine Monophosphate-Activated Protein Kinase (AMPK) by Ryder, Tim F, Calabrese, Matthew F, Walker, Gregory S, Cameron, Kimberly O, Reyes, Allan R, Borzilleri, Kris A, Delmore, Jake, Miller, Russell, Kurumbail, Ravi G, Ward, Jessica, Kung, Daniel W, Brown, Janice A, Edmonds, David J, Eng, Heather, Wolford, Angela C, Kalgutkar, Amit S

“…Studies on indole-3-carboxylic acid derivatives as direct activators of human adenosine monophosphate-activated protein kinase (AMPK) α1β1γ1 isoform have…”
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Optimization of Metabolic and Renal Clearance in a Series of Indole Acid Direct Activators of 5′-Adenosine Monophosphate-Activated Protein Kinase (AMPK) by Edmonds, David J, Kung, Daniel W, Kalgutkar, Amit S, Filipski, Kevin J, Ebner, David C, Cabral, Shawn, Smith, Aaron C, Aspnes, Gary E, Bhattacharya, Samit K, Borzilleri, Kris A, Brown, Janice A, Calabrese, Matthew F, Caspers, Nicole L, Cokorinos, Emily C, Conn, Edward L, Dowling, Matthew S, Eng, Heather, Feng, Bo, Fernando, Dilinie P, Genung, Nathan E, Herr, Michael, Kurumbail, Ravi G, Lavergne, Sophie Y, Lee, Esther C.-Y, Li, Qifang, Mathialagan, Sumathy, Miller, Russell A, Panteleev, Jane, Polivkova, Jana, Rajamohan, Francis, Reyes, Allan R, Salatto, Christopher T, Shavnya, Andre, Thuma, Benjamin A, Tu, Meihua, Ward, Jessica, Withka, Jane M, Xiao, Jun, Cameron, Kimberly O

“…Optimization of the pharmacokinetic (PK) properties of a series of activators of adenosine monophosphate-activated protein kinase (AMPK) is described…”
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Biophysical Interactions of Direct AMPK Activators by Kurumbail, Ravi G, West, Graham M, Dharmarajan, Venkatasubramanian, Borzilleri, Kris A, Withka, Jane M, Ward, Jessica, Reyes, Allan R, Rajamohan, Francis, Griffin, Patrick R, Calabrese, Matthew F

“…Protein-ligand interactions can be evaluated by a number of different biophysical methods. Here we describe some of the experimental methods that we have used…”
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Development of a selective activity-based probe for glycosylated LIPA by Schwaid, Adam G., Ruangsiriluk, Wanida, Reyes, Allan R., Cabral, Shawn, Rajamohan, Francis, Tu, Meihua, Ward, Jessica, Carpino, Philip A.

“…[Display omitted] Loss of LIPA activity leads to diseases such as Wolman’s Disease and Cholesterol Ester Storage Disease. While it is possible to measure…”
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Structure-guided Inhibitor Design for Human Acetyl-coenzyme A Carboxylase by Interspecies Active Site Conversion by Rajamohan, Francis, Marr, Eric, Reyes, Allan R., Landro, James A., Anderson, Marie D., Corbett, Jeffrey W., Dirico, Kenneth J., Harwood, James H., Tu, Meihua, Vajdos, Felix F.

“…Inhibition of acetyl-CoA carboxylases (ACCs), a crucial enzyme for fatty acid metabolism, has been shown to promote fatty acid oxidation and reduce body fat in…”
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Structural Basis for AMPK Activation: Natural and Synthetic Ligands Regulate Kinase Activity from Opposite Poles by Different Molecular Mechanisms by Calabrese, Matthew F., Rajamohan, Francis, Harris, Melissa S., Caspers, Nicole L., Magyar, Rachelle, Withka, Jane M., Wang, Hong, Borzilleri, Kris A., Sahasrabudhe, Parag V., Hoth, Lise R., Geoghegan, Kieran F., Han, Seungil, Brown, Janice, Subashi, Timothy A., Reyes, Allan R., Frisbie, Richard K., Ward, Jessica, Miller, Russell A., Landro, James A., Londregan, Allyn T., Carpino, Philip A., Cabral, Shawn, Smith, Aaron C., Conn, Edward L., Cameron, Kimberly O., Qiu, Xiayang, Kurumbail, Ravi G.

“…AMP-activated protein kinase (AMPK) is a principal metabolic regulator affecting growth and response to cellular stress. Comprised of catalytic and regulatory…”
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Acyl Glucuronide Metabolites of 6‑Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]‑1H‑indole-3-carboxylic Acid (PF-06409577) and Related Indole-3-carboxylic Acid Derivatives are Direct Activators of Adenosine Monophosphate-Activated Protein Kinase (AMPK) by Ryder, Tim F., Calabrese, Matthew F., Walker, Gregory S., Cameron, Kimberly O., Reyes, Allan R., Borzilleri, Kris A., Delmore, Jake, Miller, Russell, Kurumbail, Ravi G., Ward, Jessica, Kung, Daniel W., Brown, Janice A., Edmonds, David J., Eng, Heather, Wolford, Angela C., Kalgutkar, Amit S.

“…Studies on indole-3-carboxylic acid derivatives as direct activators of human adenosine monophosphate-activated protein kinase (AMPK) α1β1γ1 isoform have…”
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Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1 H -indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy by Cameron, Kimberly O., Kung, Daniel W., Kalgutkar, Amit S., Kurumbail, Ravi G., Miller, Russell, Salatto, Christopher T., Ward, Jessica, Withka, Jane M., Bhattacharya, Samit K., Boehm, Markus, Borzilleri, Kris A., Brown, Janice A., Calabrese, Matthew, Caspers, Nicole L., Cokorinos, Emily, Conn, Edward L., Dowling, Matthew S., Edmonds, David J., Eng, Heather, Fernando, Dilinie P., Frisbie, Richard, Hepworth, David, Landro, James, Mao, Yuxia, Rajamohan, Francis, Reyes, Allan R., Rose, Colin R., Ryder, Tim, Shavnya, Andre, Smith, Aaron C., Tu, Meihua, Wolford, Angela C., Xiao, Jun

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Escherichia coli expression, purification and characterization of functional full-length recombinant α2β2γ3 heterotrimeric complex of human AMP-activated protein kinase by Rajamohan, Francis, Harris, Melissa S., Frisbie, Richard K., Hoth, Lise R., Geoghegan, Kieran F., Valentine, James J., Reyes, Allan R., Landro, James A., Qiu, Xiayang, Kurumbail, Ravi G.

“…AMP-activated protein kinase (AMPK) is an energy-sensing serine/threonine protein kinase that plays a central role in whole-body energy homeostasis. AMPK is a…”
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Escherichia coli expression, purification and characterization of functional full-length recombinant a2b2g3 heterotrimeric complex of human AMP-activated protein kinase by Rajamohan, Francis, Harris, Melissa S, Frisbie, Richard K, Hoth, Lise R, Geoghegan, Kieran F, Valentine, James J, Reyes, Allan R, Landro, James A, Qiu, Xiayang, Kurumbail, Ravi G

“…AMP-activated protein kinase (AMPK) is an energy-sensing serine/threonine protein kinase that plays a central role in whole-body energy homeostasis. AMPK is a…”
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Escherichia coli expression, purification and characterization of functional full-length recombinant alpha2beta2gamma3 heterotrimeric complex of human AMP-activated protein kinase by Rajamohan, Francis, Harris, Melissa S, Frisbie, Richard K, Hoth, Lise R, Geoghegan, Kieran F, Valentine, James J, Reyes, Allan R, Landro, James A, Qiu, Xiayang, Kurumbail, Ravi G

“…AMP-activated protein kinase (AMPK) is an energy-sensing serine/threonine protein kinase that plays a central role in whole-body energy homeostasis. AMPK is a…”
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