Search Results - "Rewell, S"

Evolution of ischemic damage and behavioural deficit over 6 months after MCAo in the rat: Selecting the optimal outcomes and statistical power for multi-centre preclinical trials by Rewell, Sarah S J, Churilov, Leonid, Sidon, T Kate, Aleksoska, Elena, Cox, Susan F, Macleod, Malcolm R, Howells, David W

“…Key disparities between the timing and methods of assessment in animal stroke studies and clinical trial may be part of the reason for the failure to translate…”
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Different strokes for different folks: the rich diversity of animal models of focal cerebral ischemia by Howells, David W, Porritt, Michelle J, Rewell, Sarah SJ, O'Collins, Victoria, Sena, Emily S, van der Worp, H Bart, Traystman, Richard J, Macleod, Malcolm R

“…No single animal model is able to encompass all of the variables known to affect human ischemic stroke. This review highlights the major strengths and…”
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Modelling lung infection with Klebsiella pneumoniae after murine traumatic brain injury by Shad, Ali, Rewell, Sarah S J, Macowan, Matthew, Gandasasmita, Natasha, Wang, Jiping, Chen, Ke, Marsland, Ben, O'Brien, Terence J, Li, Jian, Semple, Bridgette D

“…Pneumonia is a common comorbidity in patients with severe traumatic brain injury (TBI), and is associated with increased morbidity and mortality. In this…”
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Incidence of post-traumatic epilepsy following paediatric traumatic brain injury: protocol for systematic review and meta-analysis by Mariajoseph, Frederick P, Rewell, Sarah S, O'Brien, Terence J, Semple, Bridgette D, Antonic-Baker, Ana

“…IntroductionPost-traumatic epilepsy (PTE) is a recognised complication of traumatic brain injury (TBI), and is associated with higher rates of mortality and…”
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Reduced bone formation markers, and altered trabecular and cortical bone mineral densities of non-paretic femurs observed in rats with ischemic stroke: A randomized controlled pilot study by Borschmann, Karen N, Rewell, Sarah S, Iuliano, Sandra, Ghasem-Zadeh, Ali, Davey, Rachel A, Ho, Heidi, Skeers, Peta N, Bernhardt, Julie, Howells, David W

“…Immobility and neural damage likely contribute to accelerated bone loss after stroke, and subsequent heightened fracture risk in humans. To investigate the…”
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A combined pre-clinical meta-analysis and randomized confirmatory trial approach to improve data validity for therapeutic target validation by Kleikers, Pamela WM, Hooijmans, Carlijn, Göb, Eva, Langhauser, Friederike, Rewell, Sarah SJ, Radermacher, Kim, Ritskes-Hoitinga, Merel, Howells, David W., Kleinschnitz, Christoph, HHW Schmidt, Harald

“…Biomedical research suffers from a dramatically poor translational success. For example, in ischemic stroke, a condition with a high medical need, over a…”
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Inducing stroke in aged, hypertensive, diabetic rats by Rewell, Sarah SJ, Fernandez, John A, Cox, Susan F, Spratt, Neil J, Hogan, Lisa, Aleksoska, Elena, van Raay, Leena, Liberatore, Gabriel T, Batchelor, Peter E, Howells, David W

“…Animal models of ischemic stroke often neglect comorbidities common in patients. This study shows the feasibility of inducing stroke by 2 h of thread occlusion…”
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Incidence and risk factors of posttraumatic epilepsy following pediatric traumatic brain injury: A systematic review and meta‐analysis by Mariajoseph, Frederick P., Chen, Zhibin, Sekhar, Praba, Rewell, Sarah S., O'Brien, Terence J., Antonic‐Baker, Ana, Semple, Bridgette D.

“…Posttraumatic epilepsy (PTE) is a well‐known chronic complication following traumatic brain injury (TBI). Despite some evidence that age at the time of injury…”
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Modulating chronic outcomes after pediatric traumatic brain injury: Distinct effects of social and environmental enrichment by Dill, Larissa K., Teymornejad, Sadaf, Sharma, Rishabh, Bozkurt, Salome, Christensen, Jennaya, Chu, Erskine, Rewell, Sarah S., Shad, Ali, Mychasiuk, Richelle, Semple, Bridgette D.

“…Impairments in social and cognitive function are a common consequence of pediatric traumatic brain injury (TBI). Rehabilitation has the potential to promote…”
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Fish oil diet associated with acute reperfusion related hemorrhage, and with reduced stroke-related sickness behaviors and motor impairment by Pascoe, Michaela C, Howells, David W, Crewther, David P, Constantinou, Nicki, Carey, Leeanne M, Rewell, Sarah S, Turchini, Giovanni M, Kaur, Gunveen, Crewther, Sheila G

“…Ischemic stroke is associated with motor impairment and increased incidence of affective disorders such as anxiety/clinical depression. In non-stroke…”
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ACE inhibition reduces infarction in normotensive but not hypertensive rats: correlation with cortical ACE activity by Porritt, Michelle J, Chen, Michelle, Rewell, Sarah SJ, Dean, Rachael G, Burrell, Louise M, Howells, David W

“…Angiotensin-converting enzyme (ACE) inhibition can reduce stroke risk by up to 43% in humans and reduce the associated disability, and hence understanding the…”
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Pediatric traumatic brain injury and a subsequent transient immune challenge independently influenced chronic outcomes in male mice by Sharma, Rishabh, Casillas-Espinosa, Pablo M., Dill, Larissa K., Rewell, Sarah S.J., Hudson, Matthew R., O'Brien, Terence J., Shultz, Sandy R., Semple, Bridgette D.

“…•Infections acquired after a traumatic brain injury (TBI) are a common complication.•We modeled pediatric TBI in mice followed by an acute transient immune…”
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Vascular perfusion differs in two distinct PDGFRβ‐positive zones within the ischemic core of male mice 2 weeks following photothrombotic stroke by Morris, Gary P., Gowing, Emma K., Courtney, Jo‐Maree, Coombe, Hannah E., King, Natalie E., Rewell, Sarah S. J., Howells, David W., Clarkson, Andrew N., Sutherland, Brad A.

“…Stroke therapy has largely focused on preventing damage and encouraging repair outside the ischemic core, as the core is considered irreparable. Recently,…”
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The Spatio-temporal Distribution of Migrating Pericytes in a Rat Model of Stroke: The Expression of Definitive Cell Markers by Sharma, V, Ling, T, Wookey, P, Rewell, S, Howells, D, Hare, D

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A Novel Population of α-Smooth Muscle Actin-Positive Cells Activated in a Rat Model of Stroke: An Analysis of the Spatio-Temporal Distribution in Response to Ischemia by Sharma, Varun, Ling, Tina W, Rewell, Sarah S, Hare, David L, Howells, David W, Kourakis, Angela, Wookey, Peter J

“…In a rat model of stroke, the spatio-temporal distribution of α-smooth muscle actin-positive, (αSMA+) cells was investigated in the infarcted hemisphere…”
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Hypothermia revisited: Impact of ischaemic duration and between experiment variability by Rewell, Sarah SJ, Jeffreys, Amy L, Sastra, Steven A, Cox, Susan F, Fernandez, John A, Aleksoska, Elena, van der Worp, H Bart, Churilov, Leonid, Macleod, Malcolm R, Howells, David W

“…To assess the true effect of novel therapies for ischaemic stroke, a positive control that can validate the experimental model and design is vital. Hypothermia…”
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Vascular perfusion differs in two distinct PDGFRβ‐positive zones within the ischemic core of male mice 2weeks following photothrombotic stroke by Morris, Gary P, Gowing, Emma K, Jo‐Maree Courtney, Coombe, Hannah E, King, Natalie E, Rewell, Sarah S J, Howells, David W, Clarkson, Andrew N, Sutherland, Brad A

“…Stroke therapy has largely focused on preventing damage and encouraging repair outside the ischemic core, as the core is considered irreparable. Recently,…”
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A novel population of [alpha]-smooth muscle actin-positive cells activated in a rat model of stroke: an analysis of the spatio-temporal distribution in response to ischemia by Sharma, Varun, Ling, Tina W, Rewell, Sarah S, Hare, David L, Howells, David W, Kourakis, Angela, Wookey, Peter J

“…In a rat model of stroke, the spatio-temporal distribution of α-smooth muscle actin-positive, (αSMA+) cells was investigated in the infarcted hemisphere…”
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An improved technique for silicone-coating the suture used in rat MCA occlusion increases stroke induction rate, reduces mortality, and is effective across a wide weight and age range by Spratt, Neil J, Fernandez, John A C, Chen, Michelle, Rewell, Sarah S J, Cox, Susan F, van Raay, Leena, Hogan, Lisa, Howells, David W

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