The neuromediator mechanism of the additive action of the delta sleep-inducing peptide in experimental audiogenic epilepsy caused by hypokinesia

The DSIP influence on the rat cortex, thalamic and hypothalamic adrenaline, noradrenaline, DOPA, dopamine and serotonin level under normal, hypokinetic stress condition (1 h in duration) and experimental audiogenic epilepsy was studied. It was found, that a single intraperitoneal DSIP injection (12...

Full description

Saved in:

Bibliographic Details
Published in:	Ėksperimentalʹnaâ i kliničeskaâ farmacologiâ Vol. 59; no. 1; p. 8
Main Authors:	Mendzheritskiĭ, A M, Uskova, N I, Lysenko, A V, Revinskiĭ, Iu V
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-01-1996
Subjects:	Acoustic Stimulation - methods Animals Brain Chemistry - drug effects Catecholamines - analysis Cerebral Cortex - chemistry Cerebral Cortex - drug effects Delta Sleep-Inducing Peptide - pharmacology Epilepsy - etiology Epilepsy - metabolism Female Hypokinesia - complications Hypokinesia - metabolism Hypothalamus - chemistry Hypothalamus - drug effects Male Neurotransmitter Agents - pharmacology Rats Thalamus - chemistry Thalamus - drug effects
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	The DSIP influence on the rat cortex, thalamic and hypothalamic adrenaline, noradrenaline, DOPA, dopamine and serotonin level under normal, hypokinetic stress condition (1 h in duration) and experimental audiogenic epilepsy was studied. It was found, that a single intraperitoneal DSIP injection (12 microns/100 g body weigh, 1 h before placing the animals into the stress condition) prevented spontaneous epileptic activity development due to creation of optimal ratio between monoamines in brain structures.
ISSN:	0869-2092