Search Results - "Revilloud, Jean"
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Light-driven biological actuators to probe the rheology of 3D microtissues
Published in Nature communications (09-02-2023)“…The mechanical properties of biological tissues are key to their physical integrity and function. Although external loading or biochemical treatments allow the…”
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Viscoelastic Properties in Cancer: From Cells to Spheroids
Published in Cells (Basel, Switzerland) (06-07-2021)“…AFM-based rheology methods enable the investigation of the viscoelastic properties of cancer cells. Such properties are known to be essential for cell…”
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3
Characterization of Loss-Of-Function KCNJ2 Mutations in Atypical Andersen Tawil Syndrome
Published in Frontiers in genetics (25-11-2021)“…Andersen-Tawil Syndrome (ATS) is a rare disease defined by the association of cardiac arrhythmias, periodic paralysis and dysmorphic features, and is caused by…”
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C-terminal engineering of CXCL12 and CCL5 chemokines: functional characterization by electrophysiological recordings
Published in PloS one (31-01-2014)“…Chemokines are chemotactic cytokines comprised of 70-100 amino acids. The chemokines CXCL12 and CCL5 are the endogenous ligands of the CXCR4 and CCR5 G…”
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β2-Adrenergic ion-channel coupled receptors as conformational motion detectors
Published in PloS one (25-03-2011)“…Ion Channel-Coupled Receptors (ICCRs) are artificial proteins comprised of a G protein-coupled receptor and a fused ion channel, engineered to couple channel…”
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6
Coassembly of different sulfonylurea receptor subtypes extends the phenotypic diversity of ATP-sensitive potassium (KATP) channels
Published in Molecular pharmacology (01-11-2008)“…K(ATP) channels are metabolic sensors and targets of potassium channel openers (KCO; e.g., diazoxide and pinacidil). They comprise four sulfonylurea receptors…”
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7
Three C-terminal residues from the sulphonylurea receptor contribute to the functional coupling between the KATP channel subunits SUR2A and Kir6.2
Published in The Journal of physiology (01-07-2008)“…Cardiac ATP-sensitive potassium (K ATP ) channels are metabolic sensors formed by the association of the inward rectifier potassium channel Kir6.2 and the…”
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8
Force propagation between epithelial cells depends on active coupling and mechano-structural polarization
Published in eLife (07-08-2023)“…Cell-generated forces play a major role in coordinating the large-scale behavior of cell assemblies, in particular during development, wound healing and…”
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The intriguing role of collagen on the rheology of cancer cell spheroids
Published in Journal of biomechanics (01-08-2022)“…Spheroids are multicellular systems with an interesting rheology giving rise to elasto-visco-plastic properties. They are good tumor models, but the role of…”
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10
Ion channel reporter for monitoring the activity of engineered GPCRs
Published in Methods in enzymology (2015)“…Ion channel-coupled receptor (ICCR) is a recent technology based on the fusion of G protein-coupled receptors (GPCRs) to an ion channel. Binding of ligands on…”
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Coupling ion channels to receptors for biomolecule sensing
Published in Nature nanotechnology (01-10-2008)“…Nanoscale electrical biosensors are promising tools for diagnostics and high-throughput screening systems. The electrical signal allows label-free assays with…”
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Functional mapping of the N-terminal arginine cluster and C-terminal acidic residues of Kir6.2 channel fused to a G protein-coupled receptor
Published in Biochimica et biophysica acta. Biomembranes (01-10-2017)“…Ion channel-coupled receptors (ICCRs) are original man-made ligand-gated ion channels created by fusion of G protein-coupled receptors (GPCRs) to the…”
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13
sub.2-Adrenergic Ion-Channel Coupled Receptors as Conformational Motion Detectors
Published in PloS one (25-03-2011)“…Ion Channel-Coupled Receptors (ICCRs) are artificial proteins comprised of a G protein-coupled receptor and a fused ion channel, engineered to couple channel…”
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14
Tuning the allosteric regulation of artificial muscarinic and dopaminergic ligand-gated potassium channels by protein engineering of G protein-coupled receptors
Published in Scientific reports (01-02-2017)“…Ligand-gated ion channels enable intercellular transmission of action potential through synapses by transducing biochemical messengers into electrical signal…”
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15
Ion-Channel Coupled Receptors: New Tools for the Study of Receptors and Channels
Published in Biophysical journal (31-01-2012)Get full text
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16
Functional characterization of the Ca 2+ -ATPase SMA1 from Schistosoma mansoni
Published in Biochemical journal (11-01-2018)“…is a parasite that causes bilharzia, a neglected tropical disease affecting hundreds of millions of people each year worldwide. In 2012, had been identified as…”
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17
Remodelling of the SUR–Kir6.2 interface of the KATP channel upon ATP binding revealed by the conformational blocker rhodamine 123
Published in The Journal of physiology (01-07-2007)“…ATP‐sensitive K+ channels (KATP channels) are metabolic sensors formed by association of a K+ channel, Kir6, and an ATP‐binding cassette (ABC) protein, SUR,…”
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18
Three C-terminal residues from the sulphonylurea receptor contribute to the functional coupling between the K(ATP) channel subunits SUR2A and Kir6.2
Published in The Journal of physiology (01-07-2008)“…Cardiac ATP-sensitive potassium (K(ATP)) channels are metabolic sensors formed by the association of the inward rectifier potassium channel Kir6.2 and the…”
Get full text
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19
Remodelling of the SUR–Kir6.2 interface of the K ATP channel upon ATP binding revealed by the conformational blocker rhodamine 123
Published in The Journal of physiology (01-07-2007)“…ATP‐sensitive K + channels (K ATP channels) are metabolic sensors formed by association of a K + channel, Kir6, and an ATP‐binding cassette (ABC) protein, SUR,…”
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Artificial Ligand-Gated Channels Engineered by Assembly of Potassium Channels and G-Protein Coupled Receptors
Published in Biophysical journal (01-02-2009)Get full text
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