The role of P2Y1 receptor signaling in central respiratory control

The role of P2Y1 receptor signaling in central respiratory control

Highlights • We review the role of P2Y1 receptor signaling in central respiratory control. • P2Y1 receptors do not appear to contribute to the chemosensitivity of RTN neurons. • P2Y1 receptors in the preBötC appear to attenuate the hypoxic respiratory depression. • Effects on rhythm are likely media...

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Bibliographic Details
Published in:Respiratory physiology & neurobiology Vol. 226; pp. 3 - 10
Main Authors: Rajani, V, Zhang, Y, Revill, A.L, Funk, G.D
Format: Journal Article
Language:English
Published: Netherlands Elsevier B.V 01-06-2016
Subjects:
Animals
Central chemoreception
Central Nervous System - metabolism
Hypoxia
Medical Education
PreBötzinger complex
Pulmonary/Respiratory
Purine receptor
Receptors, Purinergic P2Y1 - metabolism
Respiration
Retrotrapezoid nucleus
Signal Transduction
Hypoxia
Central chemoreception
Purine receptor
Retrotrapezoid nucleus
PreBötzinger complex
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Summary:Highlights • We review the role of P2Y1 receptor signaling in central respiratory control. • P2Y1 receptors do not appear to contribute to the chemosensitivity of RTN neurons. • P2Y1 receptors in the preBötC appear to attenuate the hypoxic respiratory depression. • Effects on rhythm are likely mediated by Gαq GPCRs, perhaps via KCNQ, TASK or BK/SK. • Signaling pathways through which P2Y1 receptors may modulate rhythm are reviewed.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1569-9048
1878-1519
DOI:10.1016/j.resp.2015.10.003