Search Results - "Revenko, Alexey S"

Blood-derived plasminogen drives brain inflammation and plaque deposition in a mouse model of Alzheimer’s disease by Baker, Sarah K., Chen, Zu-Lin, Norris, Erin H., Revenko, Alexey S., MacLeod, A. Robert, Strickland, Sidney

“…Two of the most predominant features of the Alzheimer’s disease (AD) brain are deposition of β-amyloid (Aβ) plaques and inflammation. The mechanism behind…”
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Differential uptake, kinetics and mechanisms of intracellular trafficking of next-generation antisense oligonucleotides across human cancer cell lines by Linnane, Emily, Davey, Paul, Zhang, Pei, Puri, Sanyogitta, Edbrooke, Mark, Chiarparin, Elisabetta, Revenko, Alexey S, Macleod, A Robert, Norman, Jim C, Ross, Sarah J

“…Abstract Antisense oligonucleotides (ASOs) modulate cellular target gene expression through direct binding to complementary RNA. Advances in ASO chemistry have…”
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Cellular uptake mediated by epidermal growth factor receptor facilitates the intracellular activity of phosphorothioate-modified antisense oligonucleotides by Wang, Shiyu, Allen, Nickolas, Vickers, Timothy A, Revenko, Alexey S, Sun, Hong, Liang, Xue-hai, Crooke, Stanley T

“…Abstract Chemically modified antisense oligonucleotides (ASOs) with phosphorothioate (PS) linkages have been extensively studied as research and therapeutic…”
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Thrombin Signaling Promotes Pancreatic Adenocarcinoma through PAR-1-Dependent Immune Evasion by Yang, Yi, Stang, Amanda, Schweickert, Patrick G, Lanman, Nadia A, Paul, Erin N, Monia, Brett P, Revenko, Alexey S, Palumbo, Joseph S, Mullins, Eric S, Elzey, Bennett D, Janssen, Edith M, Konieczny, Stephen F, Flick, Matthew J

“…Pancreatic ductal adenocarcinoma (PDAC) is associated with robust activity of the coagulation system. To determine mechanisms by which clotting factors…”
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Selective depletion of plasma prekallikrein or coagulation factor XII inhibits thrombosis in mice without increased risk of bleeding by Revenko, Alexey S., Gao, Dacao, Crosby, Jeff R., Bhattacharjee, Gourab, Zhao, Chenguang, May, Chris, Gailani, David, Monia, Brett P., MacLeod, A. Robert

“…Recent studies indicate that the plasma contact system plays an important role in thrombosis, despite being dispensable for hemostasis. For example, mice…”
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Antithrombotic Effect of Antisense Factor XI Oligonucleotide Treatment in Primates by Crosby, Jeffrey R, Marzec, Ulla, Revenko, Alexey S, Zhao, Chenguang, Gao, Dacao, Matafonov, Anton, Gailani, David, MacLeod, A Robert, Tucker, Erik I, Gruber, Andras, Hanson, Stephen R, Monia, Brett P

“…OBJECTIVE—During coagulation, factor IX (FIX) is activated by 2 distinct mechanisms mediated by the active proteases of either FVIIa or FXIa. Both coagulation…”
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Simultaneous inhibition of endocytic recycling and lysosomal fusion sensitizes cells and tissues to oligonucleotide therapeutics by Finicle, Brendan T, Eckenstein, Kazumi H, Revenko, Alexey S, Anderson, Brooke A, Wan, W Brad, McCracken, Alison N, Gil, Daniel, Fruman, David A, Hanessian, Stephen, Seth, Punit P, Edinger, Aimee L

“…Inefficient endosomal escape remains the primary barrier to the broad application of oligonucleotide therapeutics. Liver uptake after systemic administration…”
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CFTR mRNAs with nonsense codons are degraded by the SMG6-mediated endonucleolytic decay pathway by Sanderlin, Edward J., Keenan, Melissa M., Mense, Martin, Revenko, Alexey S., Monia, Brett P., Guo, Shuling, Huang, Lulu

“…Approximately 10% of cystic fibrosis patients harbor nonsense mutations in the cystic fibrosis transmembrane conductance regulator ( CFTR ) gene which can…”
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Chromatin Loading of E2F-MLL Complex by Cancer-Associated Coregulator ANCCA via Reading a Specific Histone Mark by Revenko, Alexey S., Kalashnikova, Ekaterina V., Gemo, Abigael T., Zou, June X., Chen, Hong-Wu

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The contact system proteases play disparate roles in streptococcal sepsis by Köhler, Juliane, Maletzki, Claudia, Koczan, Dirk, Frank, Marcus, Trepesch, Carolin, Revenko, Alexey S, Crosby, Jeffrey R, Macleod, A Robert, Mikkat, Stefan, Oehmcke-Hecht, Sonja

“…Sepsis causes an activation of the human contact system, an inflammatory response mechanism against foreign surfaces, proteins and pathogens. The serine…”
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Androgen-Induced Coactivator ANCCA Mediates Specific Androgen Receptor Signaling in Prostate Cancer by ZOU, June X, LINLANG GUO, REVENKO, Alexey S, TEPPER, Clifford G, GEMO, Abigael T, KUNG, Hsing-Jien, CHEN, Hong-Wu

“…Androgen receptor (AR) plays a pivotal role in prostate cancer, primarily by regulating different gene expression programs elicited by androgen, which is…”
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Plasmin Prevents Dystrophic Calcification After Muscle Injury by Mignemi, Nicholas A, Yuasa, Masato, Baker, Courtney E, Moore, Stephanie N, Ihejirika, Rivka C, Oelsner, William K, Wallace, Christopher S, Yoshii, Toshitaka, Okawa, Atsushi, Revenko, Alexey S, MacLeod, A Robert, Bhattacharjee, Gourab, Barnett, Joey V, Schwartz, Herbert S, Degen, Jay L, Flick, Matthew J, Cates, Justin M, Schoenecker, Jonathan G

“…ABSTRACT Extensive or persistent calcium phosphate deposition within soft tissues after severe traumatic injury or major orthopedic surgery can result in pain…”
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Plasminogen deficiency suppresses pancreatic ductal adenocarcinoma disease progression by Chowdhury, Nayela N., Yang, Yi, Dutta, Ananya, Luo, Michelle, Wei, Zimu, Abrahams, Sara R., Revenko, Alexey S., Shah, Fenil, Miles, Lindsey A., Parmer, Robert J., Laat, Bas, Wolberg, Alisa S., Luyendyk, James P., Fishel, Melissa L., Flick, Matthew J.

“…Pancreatic ductal adenocarcinoma (PDAC) is a highly fatal metastatic disease associated with robust activation of the coagulation and fibrinolytic systems…”
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STAT6-targeting antisense oligonucleotides against solitary fibrous tumor by Li, Yi, Mondaza-Hernandez, Jose L., Moura, David S., Revenko, Alexey S., Tolentino, Angelica, Nguyen, John T., Tran, Nam, Meyer, Clark A., Merino-Garcia, Jose, Ramos, Rafael, Di Lernia, Davide, Martin-Broto, Javier, Hayenga, Heather N., Bleris, Leonidas

“…Solitary fibrous tumor (SFT) is a rare, non-hereditary soft tissue sarcoma thought to originate from fibroblastic mesenchymal stem cells. The etiology of SFT…”
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ANCCA, an Estrogen-Regulated AAA+ ATPase Coactivator for ERα, Is Required for Coregulator Occupancy and Chromatin Modification by Zou, June X., Revenko, Alexey S., Li, Li B., Gemo, Abigael T., Chen, Hong-Wu

“…AAA+ proteins play crucial roles in diverse biological processes via their ATPase-driven remodeling of macromolecular complexes. Here we report our…”
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Polyphosphate-induced thrombosis in mice is factor XII dependent and is attenuated by histidine-rich glycoprotein by Malik, Rida A., Zhou, Ji, Fredenburgh, James C., Truong, Tammy K., Crosby, Jeff R., Revenko, Alexey S., Weitz, Jeffrey I.

“…Histidine-rich glycoprotein (HRG) is an abundant plasma protein that binds factor XIIa (FXIIa) and inhibits factor XII (FXII) autoactivation and FXIIa-mediated…”
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Kininogen supports inflammation and bacterial spreading during Streptococccus Pyogenes Sepsis by Köhler, Juliane, Maletzki, Claudia, Koczan, Dirk, Frank, Marcus, Springer, Armin, Steffen, Carolin, Revenko, Alexey S., MacLeod, A.Robert, Mikkat, Stefan, Kreikemeyer, Bernd, Oehmcke-Hecht, Sonja

“…High-molecular-weight kininogen is a cofactor of the human contact system, an inflammatory response mechanism that is activated during sepsis. It has been…”
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Hepatic thrombopoietin gene silencing reduces platelet count and breast cancer progression in transgenic MMTV-PyMT mice by Shirai, Toshiaki, Revenko, Alexey S., Tibbitts, Justin, Ngo, Anh T.P., Mitrugno, Annachiara, Healy, Laura D., Johnson, Jennifer, Tucker, Erik I., Hinds, Monica T., Coussens, Lisa M., McCarty, Owen J.T., Monia, Brett P., Gruber, András

“…In humans, platelet count within the normal range is required for physiological hemostasis, but, adversely, platelets also support pathological thrombosis…”
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Direct Control of Cell Cycle Gene Expression by Proto-Oncogene Product ACTR, and Its Autoregulation Underlies Its Transforming Activity by Louie, Maggie C., Revenko, Alexey S., Zou, June X., Yao, Jennifer, Chen, Hong-Wu

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Knockdown of coagulation factor VII has potential anticoagulant and anti-inflammatory effects in a mouse model of group A streptococcal sepsis by Köhler, Juliane, Maletzki, Claudia, Revenko, Alexey S, Mikkat, Stefan, Kreikemeyer, Bernd, Oehmcke-Hecht, Sonja

“…Infections originating from subcutaneous tissues are among the most common invasive infections caused by group A streptococcus (GAS) and associated with…”
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