Search Results - "Revell, Jefferson D"

Tripeptides as Efficient Asymmetric Catalysts for 1,4-Addition Reactions of Aldehydes to Nitroolefins-A Rational Approach by Wiesner, Markus, Revell, Jefferson D, Wennemers, Helma

“…Bridging the gap: Conformational analysis of a peptidic catalyst for aldol reactions led to the development of H‐D‐Pro‐Pro‐Asp‐NH2 as a highly efficient…”
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Increased Structural Complexity Leads to Higher Activity:  Peptides as Efficient and Versatile Catalysts for Asymmetric Aldol Reactions by Krattiger, Philipp, Kovasy, Roman, Revell, Jefferson D, Ivan, Stanislav, Wennemers, Helma

“…Peptides containing a secondary amine and a carboxylic acid in a specific orientation to each other are presented as highly efficient catalysts for asymmetric…”
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Investigating Sequence Space: How Important is the Spatial Arrangement of Functional Groups in the Asymmetric Aldol Reaction Catalyst H-Pro-Pro-Asp-NH2? by Revell, Jefferson D., Wennemers, Helma

“…H‐Pro‐Pro‐Asp‐NH2 1 is a versatile catalyst for asymmetric aldol reactions. Within the catalyst structure, both the N‐terminal secondary amine and the…”
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Peptidic catalysts developed by combinatorial screening methods by Revell, Jefferson D, Wennemers, Helma

“…In recent years, oligopeptides have been developed as efficient catalysts for a range of important organic reactions, including acylation, silylation,…”
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Is more better? A comparison of tri- and tetrapeptidic catalysts by Schnitzer, Tobias, Wiesner, Markus, Krattiger, Philipp, Revell, Jefferson D, Wennemers, Helma

“…From an enzymatic perspective, there is a general notion that the bigger and more complex a catalytically active peptide is the more enzyme-like and the better…”
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Stapled Vasoactive Intestinal Peptide (VIP) Derivatives Improve VPAC2 Agonism and Glucose-Dependent Insulin Secretion by Giordanetto, Fabrizio, Revell, Jefferson D, Knerr, Laurent, Hostettler, Marie, Paunovic, Amalia, Priest, Claire, Janefeldt, Annika, Gill, Adrian

“…Agonists of vasoactive intestinal peptide receptor 2 (VPAC2) stimulate glucose-dependent insulin secretion, making them attractive candidates for the treatment…”
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Potency optimization of Huwentoxin-IV on hNav1.7: A neurotoxin TTX-S sodium-channel antagonist from the venom of the Chinese bird-eating spider Selenocosmia huwena by Revell, Jefferson D., Lund, Per-Eric, Linley, John E., Metcalfe, Jacky, Burmeister, Nicole, Sridharan, Sudharsan, Jones, Clare, Jermutus, Lutz, Bednarek, Maria A.

“…•Venom peptide Huwentoxin-IV is potent antagonist of hNav1.7 (IC50=17nM determined herein).•Nav1.7 is involved in generation and conduction of neuropathic and…”
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Ionic Liquid Acceleration of Solid-Phase Suzuki−Miyaura Cross-Coupling Reactions by Revell, Jefferson D, Ganesan, A

“…Room-temperature ionic liquids promote various transition metal-catalyzed reactions in the solution phase. Here, for the first time, we show that these effects…”
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Solid-supported and pegylated H-Pro-Pro-Asp-NHR as catalysts for asymmetric aldol reactions by Revell, Jefferson D., Gantenbein, Daniel, Krattiger, Philipp, Wennemers, Helma

“…H–Pro–Pro–Asp–NH2 is a highly active and selective catalyst for asymmetric aldol reactions. Here, the versatility of H–Pro–Pro–Asp–NH2 has been further…”
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Separating stereoisomers of di-, tri-, and tetrapeptides using capillary electrophoresis with contactless conductivity detection by Gong, Xiao Yang, Dobrunz, Dominik, Kümin, Michael, Wiesner, Markus, Revell, Jefferson D, Wennemers, Helma, Hauser, Peter C

“…The separation and detection of small oligopeptides in CE with contactless conductivity detection were demonstrated. A strongly acidic separation buffer (0.5 M…”
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Peptide–polyethylene glycol conjugates: Synthesis and properties of peptides bearing a C-terminal polyethylene glycol chain by Grun, Jessica, Revell, Jefferson D., Conza, Matteo, Wennemers, Helma

“…The introduction of a polyethylene glycol chain has become a popular tool for increasing water solubility and bioavailability. Our interest in the development…”
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Peptide Catalyzed Asymmetric Conjugate Addition Reactions of Aldehydes to Nitroethylene—A Convenient Entry into γ2-Amino Acids by Wiesner, Markus, Revell, Jefferson D, Tonazzi, Sandro, Wennemers, Helma

“…The peptide H-d-Pro-Pro-Glu-NH2 is a highly effective catalyst for conjugate addition reactions between aldehydes and nitroethylene. Only 1 mol % of…”
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PS-COD and PS-9-BBN:  Polymer-Supported Reagents for Solution-Phase Parallel Synthesis by Revell, Jefferson D, Dörner, Barbara, White, Peter D, Ganesan, A

“…1,5-Cyclooctadiene was deprotonated under LICKOR conditions and reacted with Merrifield resin to afford an immobilized cyclooctadiene in high yield. This…”
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Synthesis of Functionalized 1,5-Cyclooctadienes by LICKOR Metalation by Revell, Jefferson D, Ganesan, A

“…1,5-Cyclooctadiene was lithiated under LICKOR superbase conditions followed by reaction with alkyl halides or ethylene oxide to yield 3-substituted…”
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Tripeptides as Efficient Asymmetric Catalysts for 1,4-Addition Reactions of Aldehydes to Nitroolefins-A Rational Approach by Wiesner, Markus, Revell, Jefferson D., Wennemers, Helma

“…Geplante Abstände: Basierend auf der Konformationsanalyse eines peptidischen Katalysators für Aldolreaktionen wurde das Peptid H‐D‐Pro‐Pro‐Asp‐NH2 als ein hoch…”
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Functional group requirements within the peptide H-Pro-Pro-Asp-NH2 as a catalyst for aldol reactions by Revell, Jefferson D., Wennemers, Helma

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Stapled Vasoactive Intestinal Peptide (VIP) Derivatives Improve VPAC 2 Agonism and Glucose-Dependent Insulin Secretion by Giordanetto, Fabrizio, Revell, Jefferson D., Knerr, Laurent, Hostettler, Marie, Paunovic, Amalia, Priest, Claire, Janefeldt, Annika, Gill, Adrian

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Investigating Sequence Space: How Important is the Spatial Arrangement of Functional Groups in the Asymmetric Aldol Reaction Catalyst H‐Pro‐Pro‐Asp‐NH 2 ? by Revell, Jefferson D., Wennemers, Helma

“…Abstract H‐Pro‐Pro‐Asp‐NH 2 1 is a versatile catalyst for asymmetric aldol reactions. Within the catalyst structure, both the N‐terminal secondary amine and…”
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Functional group requirements within the peptide H-Pro-Pro-Asp-NH 2 as a catalyst for aldol reactions by Revell, Jefferson D., Wennemers, Helma

“…H-Pro-Pro-Asp-NH 2 1 is a versatile catalyst for asymmetric aldol reactions. In this work, the functional group tolerance within the catalyst structure has…”
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Using Catalyst-Substrate Coimmobilization for the Discovery of Catalysts for Asymmetric Aldol Reactions in Split-and-Mix Libraries by Krattiger, Philipp, Kovàsy, Roman, Revell, Jefferson D., Wennemers, Helma

“…“Catalyst–substrate coimmobilization” has been used for the discovery of highly active and selective peptidic catalysts for asymmetric aldol reactions within…”
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