Search Results - "Revechon, G"

The Heterochromatin protein 1 is a regulator in RNA splicing precision deficient in ulcerative colitis by Mata-Garrido, Jorge, Xiang, Yao, Chang-Marchand, Yunhua, Reisacher, Caroline, Ageron, Elisabeth, Guerrera, Ida Chiara, Casafont, Iñigo, Bruneau, Aurelia, Cherbuy, Claire, Treton, Xavier, Dumay, Anne, Ogier-Denis, Eric, Batsché, Eric, Costallat, Mickael, Revêchon, Gwladys, Eriksson, Maria, Muchardt, Christian, Arbibe, Laurence

“…Defects in RNA splicing have been linked to human disorders, but remain poorly explored in inflammatory bowel disease (IBD). Here, we report that expression of…”
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Readily Available Tools to Detect Progerin and Cardiac Disease Progression in Hutchinson-Gilford Progeria Syndrome by Eriksson, Maria, Haugaa, Kristina, Revêchon, Gwladys

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Challenges of proving a causal role of somatic mutations in the aging process by Franco, Irene, Revêchon, Gwladys, Eriksson, Maria

“…Aging is accompanied by the progressive accumulation of permanent changes to the genomic sequence, termed somatic mutations. Small mutations, including…”
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Splice-inhibition therapy targets progeria by Revêchon, Gwladys, Whisenant, Daniel, Eriksson, Maria

“…Antisense oligonucleotides that target lamin A/C pre-mRNA decrease both progerin transcript levels and progerin protein levels and extend lifespan in an animal…”
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Somatic mutations in vascular wall function and age-associated disease by Revêchon, Gwladys, Merino, Lara Garcia, Machtel, Piotr, Eriksson, Maria

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Inhibition of DNA damage response at telomeres improves the detrimental phenotypes of Hutchinson–Gilford Progeria Syndrome by Aguado, Julio, Sola-Carvajal, Agustin, Cancila, Valeria, Revêchon, Gwladys, Ong, Peh Fern, Jones-Weinert, Corey Winston, Wallén Arzt, Emelie, Lattanzi, Giovanna, Dreesen, Oliver, Tripodo, Claudio, Rossiello, Francesca, Eriksson, Maria, d’Adda di Fagagna, Fabrizio

“…Hutchinson–Gilford progeria syndrome (HGPS) is a genetic disorder characterized by premature aging features. Cells from HGPS patients express progerin, a…”
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Somatic mutagenesis in satellite cells associates with human skeletal muscle aging by Franco, Irene, Johansson, Anna, Olsson, Karl, Vrtačnik, Peter, Lundin, Pär, Helgadottir, Hafdis T., Larsson, Malin, Revêchon, Gwladys, Bosia, Carla, Pagnani, Andrea, Provero, Paolo, Gustafsson, Thomas, Fischer, Helene, Eriksson, Maria

“…Human aging is associated with a decline in skeletal muscle (SkM) function and a reduction in the number and activity of satellite cells (SCs), the resident…”
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Transient expression of an adenine base editor corrects the Hutchinson-Gilford progeria syndrome mutation and improves the skin phenotype in mice by Whisenant, Daniel, Lim, Kayeong, Revêchon, Gwladys, Yao, Haidong, Bergo, Martin O., Machtel, Piotr, Kim, Jin-Soo, Eriksson, Maria

“…Hutchinson-Gilford progeria syndrome (HGPS) is a rare premature ageing disorder caused by a point mutation in the LMNA gene ( LMNA c.1824 C > T), resulting in…”
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Accumulation of Progerin Affects the Symmetry of Cell Division and Is Associated with Impaired Wnt Signaling and the Mislocalization of Nuclear Envelope Proteins by Sola-Carvajal, Agustín, Revêchon, Gwladys, Helgadottir, Hafdis T., Whisenant, Daniel, Hagblom, Robin, Döhla, Julia, Katajisto, Pekka, Brodin, David, Fagerström-Billai, Fredrik, Viceconte, Nikenza, Eriksson, Maria

“…Hutchinson-Gilford progeria syndrome (HGPS) is the result of a defective form of the lamin A protein called progerin. While progerin is known to disrupt the…”
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Targeting RAS‐converting enzyme 1 overcomes senescence and improves progeria‐like phenotypes of ZMPSTE24 deficiency by Yao, Haidong, Chen, Xue, Kashif, Muhammad, Wang, Ting, Ibrahim, Mohamed X., Tüksammel, Elin, Revêchon, Gwladys, Eriksson, Maria, Wiel, Clotilde, Bergo, Martin O.

“…Several progeroid disorders are caused by deficiency in the endoprotease ZMPSTE24 which leads to accumulation of prelamin A at the nuclear envelope. ZMPSTE24…”
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A small-molecule ICMT inhibitor delays senescence of Hutchinson-Gilford progeria syndrome cells by Chen, Xue, Yao, Haidong, Kashif, Muhammad, Revêchon, Gwladys, Eriksson, Maria, Hu, Jianjiang, Wang, Ting, Liu, Yiran, Tüksammel, Elin, Strömblad, Staffan, Ahearn, Ian M, Philips, Mark R, Wiel, Clotilde, Ibrahim, Mohamed X, Bergo, Martin O

“…A farnesylated and methylated form of prelamin A called progerin causes Hutchinson-Gilford progeria syndrome (HGPS). Inhibiting progerin methylation by…”
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Rare progerin-expressing preadipocytes and adipocytes contribute to tissue depletion over time by Revêchon, Gwladys, Viceconte, Nikenza, McKenna, Tomás, Sola Carvajal, Agustín, Vrtačnik, Peter, Stenvinkel, Peter, Lundgren, Torbjörn, Hultenby, Kjell, Franco, Irene, Eriksson, Maria

“…Accumulation of progerin is believed to underlie the pathophysiology of Hutchinson-Gilford progeria syndrome, a disease characterized by clinical features…”
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Therapeutic gene editing for Hutchinson-Gilford progeria syndrome by Whisenant, D, Lim, K, Revechon, G, Eriksson, M, Kim, JS

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The Hutchinson-Gilford progeria syndrome mutation is a somatic mutation in chronic kidney disease by Eriksson, M, Helgadottir, HT, Viceconte, N, Witasp, A, Arzt, EW, Carvajal, AS, Revechon, G, Thorell, A, McGuinness, D, Shiels, PG, Wernerson, A, Stenvinkel, P

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Genome wide detection of somatic mutations in human muscle stem cells by Franco, I, Johansson, A, Olsson, K, Vrtacnik, P, Lundin, P, Helgadottir, HT, Larsson, M, Revechon, G, Bosia, C, Pagnani, A, Provero, P, Gustafsson, T, Fischer, H, Eriksson, M

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Clonal occurrence of the Hutchinson-Gilford progeria syndrome lamin A mutation in chronic kidney disease by Revechon, G, Helgadottir, H, Viceconte, N, Witasp, A, Carvajal, AS, Whisenant, D, McGuinness, D, Artiach, G, Arzt, EW, Thorell, A, Babler, A, Ziegler, S, Kramann, R, Back, M, Shiels, PG, Wernerson, A, Stenvinkel, P, Eriksson, M

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