Search Results - "Reuven, Eliran Moshe"
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The human 1‐8D gene (IFITM2) is a novel p53 independent pro‐apoptotic gene
Published in International journal of cancer (15-12-2009)“…The human 1‐8 interferon inducible gene family consists of at least 3 functional genes; 9‐27, 1‐8D and 1‐8U, which are all linked on an 18‐kb fragment of…”
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Biomimetic Glyconanoparticle Vaccine for Cancer Immunotherapy
Published in ACS nano (26-03-2019)“…Cancer immunotherapy aims to harness the immune system to combat malignant processes. Transformed cells harbor diverse modifications that lead to formation of…”
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Association between Neu5Gc carbohydrate and serum antibodies against it provides the molecular link to cancer: French NutriNet-Santé study
Published in BMC medicine (23-09-2020)“…High consumption of red and processed meat is commonly associated with increased cancer risk, particularly colorectal cancer. Antibodies against the red…”
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The HIV-1 envelope transmembrane domain binds TLR2 through a distinct dimerization motif and inhibits TLR2-mediated responses
Published in PLoS pathogens (01-08-2014)“…HIV-1 uses a number of means to manipulate the immune system, to avoid recognition and to highjack signaling pathways. HIV-1 infected cells show limited…”
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Regulation of innate immune responses by transmembrane interactions: Lessons from the TLR family
Published in Biochimica et biophysica acta (01-06-2014)“…The mammalian innate immune response is responsible for the early stages of defense against invading pathogens. One of the major receptor families facilitating…”
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Glycans in immune recognition and response
Published in Carbohydrate research (07-05-2014)“…•Neu5Gc is a dietary immunogenic sugar in humans.•It is expressed at low level on human tissues, accumulating mostly on carcinoma.•All humans have circulating…”
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The role of antibody responses against glycans in bioprosthetic heart valve calcification and deterioration
Published in Nature Medicine (01-02-2022)“…Bioprosthetic heart valves (BHVs) are commonly used to replace severely diseased heart valves but their susceptibility to structural valve degeneration (SVD)…”
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HIV-1 gp41 Transmembrane Domain Interacts with the Fusion Peptide: Implication in Lipid Mixing and Inhibition of Virus–Cell Fusion
Published in Biochemistry (Easton) (03-04-2012)“…Fusion of the human immunodeficiency virus (HIV) with target cells is mediated by the gp41 subunit of the envelope protein. Mutation and deletion studies…”
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The Transmembrane Domain of HIV‑1 gp41 Inhibits T‑Cell Activation by Targeting Multiple T‑Cell Receptor Complex Components through Its GxxxG Motif
Published in Biochemistry (Easton) (23-02-2016)“…To successfully infect and persist within its host, HIV-1 utilizes several immunosuppressive motifs within its gp41 envelope glycoprotein to manipulate and…”
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Presentation Mode of Glycans Affect Recognition of Human Serum anti-Neu5Gc IgG Antibodies
Published in Bioconjugate chemistry (16-01-2019)“…Recognition of carbohydrates by antibodies can be affected by antigen composition and density. This had been investigated in a variety of controllable…”
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Active cancer vaccine targeting carbohydrates for immunotherapy
Published in The Journal of immunology (1950) (01-05-2019)“…Abstract Transformed cells present cell surface neoantigens, including aberrantly expressed carbohydrates. Targeting tumor-associated carbohydrate antigens…”
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Characterization of immunogenic Neu5Gc in bioprosthetic heart valves
Published in Xenotransplantation (Københaven) (01-09-2016)“…Background The two common sialic acids (Sias) in mammals are N‐acetylneuraminic acid (Neu5Ac) and its hydroxylated form N‐glycolylneuraminic acid (Neu5Gc)…”
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The HIV-1 Envelope Transmembrane Domain Binds TLR2 through a Distinct Dimerization Motif and Inhibits TLR2-Mediated Responses: e1004248
Published in PLoS pathogens (01-08-2014)“…HIV-1 uses a number of means to manipulate the immune system, to avoid recognition and to highjack signaling pathways. HIV-1 infected cells show limited…”
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The Transmembrane Domains of HIV-1 gp41 and TLR-2: Contribution to Protein Assembly & Function and Novel Drug Targets
Published 01-01-2013“…Protein-protein interactions within the membrane are involved in many vital cellular processes. The interactions can be partially or fully mediated by…”
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